SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer prodrug that cross links DNA and exerts highly potent antitumor activity.

John A. Hartley, Anzu Hamaguchi, Marissa Coffils, Christopher R.H Martin, Marie Suggitt, Zhizhi Chen, Stephen J. Gregson, Luke A. Masterson, Arnaud C. Tiberghien, Janet M. Hartley, Chris Pepper, Thet Thet Lin, Chris Fegan, David E. Thurston, Phillip W. Howard

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    Biochemistry, Genetics and Molecular Biology

    Pharmacology, Toxicology and Pharmaceutical Science