Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy

Christoph Stettler; Nicholas Witt; Robyn J Tapp; Simon Thom; Sabin Allemann; Therese Tillin; Alice Stanton; Eoin O'Brien; Neil Poulter; J Ruth Gallimore; Alun D Hughes; Nish Chaturvedi

doi:10.2337/dc08-2137

Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy

Christoph Stettler
, Nicholas Witt
, Robyn J Tapp
, Simon Thom
, Sabin Allemann
, Therese Tillin
, Alice Stanton
, Eoin O'Brien
, Neil Poulter
, J Ruth Gallimore
, Alun D Hughes
, Nish Chaturvedi

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

OBJECTIVE: To study the association of the inflammatory markers serum amyloid A (SAA) and C-reactive protein (CRP) with retinal microvascular parameters in hypertensive individuals with and without type 2 diabetes.

RESEARCH DESIGN AND METHODS: This cross-sectional analysis was a substudy in 711 patients (159 with and 552 without diabetes) of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) based on digital 30-degree images of superior and inferior temporal retinal fields.

RESULTS: SAA was associated with arteriolar length-to-diameter ratio positively in nondiabetic patients (P(trend)= 0.028) but negatively in diabetic patients (P(trend)= 0.005). The difference was unlikely to be a chance finding (P = 0.007 for interaction). Similar results were found for the association of SAA with arteriolar tortuosity (P = 0.05 for interaction). Associations were less pronounced for CRP and retinal parameters.

CONCLUSIONS: Inflammatory processes are differentially involved in retinal microvascular disease in diabetic compared with nondiabetic hypertensive individuals.

Original language	English
Pages (from-to)	1098-1100
Number of pages	3
Journal	Diabetes Care
Volume	32
Issue number	6
DOIs	https://doi.org/10.2337/dc08-2137
Publication status	Published - Jun 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

C-Reactive Protein/metabolism
Cross-Sectional Studies
Diabetes Complications/epidemiology
Europe/epidemiology
Humans
Hypertension/complications
Microcirculation/physiology
Retinal Vessels/pathology
Serum Amyloid A Protein/analysis
United Kingdom/epidemiology

Access to Document

10.2337/dc08-2137

Cite this

Stettler, C., Witt, N., Tapp, R. J., Thom, S., Allemann, S., Tillin, T., Stanton, A., O'Brien, E., Poulter, N., Gallimore, J. R., Hughes, A. D., & Chaturvedi, N. (2009). Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy. Diabetes Care, 32(6), 1098-1100. https://doi.org/10.2337/dc08-2137

Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy. / Stettler, Christoph; Witt, Nicholas; Tapp, Robyn J et al.
In: Diabetes Care, Vol. 32, No. 6, 06.2009, p. 1098-1100.

Research output: Contribution to journal › Article › peer-review

Stettler, C, Witt, N, Tapp, RJ, Thom, S, Allemann, S, Tillin, T, Stanton, A, O'Brien, E, Poulter, N, Gallimore, JR, Hughes, AD & Chaturvedi, N 2009, 'Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy', Diabetes Care, vol. 32, no. 6, pp. 1098-1100. https://doi.org/10.2337/dc08-2137

@article{48dcb24abc8a46dc8a83e4de64a968eb,

title = "Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy",

abstract = "OBJECTIVE: To study the association of the inflammatory markers serum amyloid A (SAA) and C-reactive protein (CRP) with retinal microvascular parameters in hypertensive individuals with and without type 2 diabetes.RESEARCH DESIGN AND METHODS: This cross-sectional analysis was a substudy in 711 patients (159 with and 552 without diabetes) of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) based on digital 30-degree images of superior and inferior temporal retinal fields.RESULTS: SAA was associated with arteriolar length-to-diameter ratio positively in nondiabetic patients (P(trend)= 0.028) but negatively in diabetic patients (P(trend)= 0.005). The difference was unlikely to be a chance finding (P = 0.007 for interaction). Similar results were found for the association of SAA with arteriolar tortuosity (P = 0.05 for interaction). Associations were less pronounced for CRP and retinal parameters.CONCLUSIONS: Inflammatory processes are differentially involved in retinal microvascular disease in diabetic compared with nondiabetic hypertensive individuals.",

keywords = "C-Reactive Protein/metabolism, Cross-Sectional Studies, Diabetes Complications/epidemiology, Europe/epidemiology, Humans, Hypertension/complications, Microcirculation/physiology, Retinal Vessels/pathology, Serum Amyloid A Protein/analysis, United Kingdom/epidemiology",

author = "Christoph Stettler and Nicholas Witt and Tapp, \{Robyn J\} and Simon Thom and Sabin Allemann and Therese Tillin and Alice Stanton and Eoin O'Brien and Neil Poulter and Gallimore, \{J Ruth\} and Hughes, \{Alun D\} and Nish Chaturvedi",

year = "2009",

month = jun,

doi = "10.2337/dc08-2137",

language = "English",

volume = "32",

pages = "1098--1100",

journal = "Diabetes Care",

issn = "1935-5548",

publisher = "American Diabetes Association",

number = "6",

}

TY - JOUR

T1 - Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals

T2 - an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy

AU - Stettler, Christoph

AU - Witt, Nicholas

AU - Tapp, Robyn J

AU - Thom, Simon

AU - Allemann, Sabin

AU - Tillin, Therese

AU - Stanton, Alice

AU - O'Brien, Eoin

AU - Poulter, Neil

AU - Gallimore, J Ruth

AU - Hughes, Alun D

AU - Chaturvedi, Nish

PY - 2009/6

Y1 - 2009/6

N2 - OBJECTIVE: To study the association of the inflammatory markers serum amyloid A (SAA) and C-reactive protein (CRP) with retinal microvascular parameters in hypertensive individuals with and without type 2 diabetes.RESEARCH DESIGN AND METHODS: This cross-sectional analysis was a substudy in 711 patients (159 with and 552 without diabetes) of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) based on digital 30-degree images of superior and inferior temporal retinal fields.RESULTS: SAA was associated with arteriolar length-to-diameter ratio positively in nondiabetic patients (P(trend)= 0.028) but negatively in diabetic patients (P(trend)= 0.005). The difference was unlikely to be a chance finding (P = 0.007 for interaction). Similar results were found for the association of SAA with arteriolar tortuosity (P = 0.05 for interaction). Associations were less pronounced for CRP and retinal parameters.CONCLUSIONS: Inflammatory processes are differentially involved in retinal microvascular disease in diabetic compared with nondiabetic hypertensive individuals.

AB - OBJECTIVE: To study the association of the inflammatory markers serum amyloid A (SAA) and C-reactive protein (CRP) with retinal microvascular parameters in hypertensive individuals with and without type 2 diabetes.RESEARCH DESIGN AND METHODS: This cross-sectional analysis was a substudy in 711 patients (159 with and 552 without diabetes) of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) based on digital 30-degree images of superior and inferior temporal retinal fields.RESULTS: SAA was associated with arteriolar length-to-diameter ratio positively in nondiabetic patients (P(trend)= 0.028) but negatively in diabetic patients (P(trend)= 0.005). The difference was unlikely to be a chance finding (P = 0.007 for interaction). Similar results were found for the association of SAA with arteriolar tortuosity (P = 0.05 for interaction). Associations were less pronounced for CRP and retinal parameters.CONCLUSIONS: Inflammatory processes are differentially involved in retinal microvascular disease in diabetic compared with nondiabetic hypertensive individuals.

KW - C-Reactive Protein/metabolism

KW - Cross-Sectional Studies

KW - Diabetes Complications/epidemiology

KW - Europe/epidemiology

KW - Humans

KW - Hypertension/complications

KW - Microcirculation/physiology

KW - Retinal Vessels/pathology

KW - Serum Amyloid A Protein/analysis

KW - United Kingdom/epidemiology

U2 - 10.2337/dc08-2137

DO - 10.2337/dc08-2137

M3 - Article

C2 - 19244088

SN - 1935-5548

VL - 32

SP - 1098

EP - 1100

JO - Diabetes Care

JF - Diabetes Care

IS - 6

ER -

Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy

Abstract

UN SDGs

Keywords

Access to Document

Fingerprint

Cite this