Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy

Christoph Stettler, Nicholas Witt, Robyn J Tapp, Simon Thom, Sabin Allemann, Therese Tillin, Alice Stanton, Eoin O'Brien, Neil Poulter, J Ruth Gallimore, Alun D Hughes, Nish Chaturvedi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

OBJECTIVE: To study the association of the inflammatory markers serum amyloid A (SAA) and C-reactive protein (CRP) with retinal microvascular parameters in hypertensive individuals with and without type 2 diabetes.

RESEARCH DESIGN AND METHODS: This cross-sectional analysis was a substudy in 711 patients (159 with and 552 without diabetes) of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) based on digital 30-degree images of superior and inferior temporal retinal fields.

RESULTS: SAA was associated with arteriolar length-to-diameter ratio positively in nondiabetic patients (P(trend)= 0.028) but negatively in diabetic patients (P(trend)= 0.005). The difference was unlikely to be a chance finding (P = 0.007 for interaction). Similar results were found for the association of SAA with arteriolar tortuosity (P = 0.05 for interaction). Associations were less pronounced for CRP and retinal parameters.

CONCLUSIONS: Inflammatory processes are differentially involved in retinal microvascular disease in diabetic compared with nondiabetic hypertensive individuals.

Original languageEnglish
Pages (from-to)1098-1100
Number of pages3
JournalDiabetes Care
Volume32
Issue number6
DOIs
Publication statusPublished - Jun 2009
Externally publishedYes

Keywords

  • C-Reactive Protein/metabolism
  • Cross-Sectional Studies
  • Diabetes Complications/epidemiology
  • Europe/epidemiology
  • Humans
  • Hypertension/complications
  • Microcirculation/physiology
  • Retinal Vessels/pathology
  • Serum Amyloid A Protein/analysis
  • United Kingdom/epidemiology

Fingerprint Dive into the research topics of 'Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy'. Together they form a unique fingerprint.

  • Cite this