Secretory immunoglobulin A and cardiovascular reactions to mental arithmetic, cold pressor, and exercise: Effects of alpha-adrenergic blockade

C. Ring, L.K. Harrison, A. Winzer, D. Carroll, M. Drayson, M. Kendall

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

The mechanism underlying acute changes in secretory immunoglobulin A (sIgA) remains to be determined. In this experiment, sIgA and cardiovascular activity were monitored at rest and while participants performed a mental arithmetic task, cold pressor, and submaximal cycle exercise following placebo or 1 mg of the alpha‐adrenergic blocker, doxazosin. Under placebo, the tasks produced patterns of cardiovascular activity indicative of combined alpha‐ and beta‐adrenergic, alpha‐adrenergic, and beta‐adrenergic activation, respectively. Doxazosin was associated with reduced blood pressure during cold pressor, but not during arithmetic or exercise. Mental arithmetic elicited increases in sIgA concentration and exercise produced increases in both sIgA concentration and secretion rate; these changes were unaffected by alpha blockade. In contrast, the cold pressor was associated with decreases in both sIgA concentration and secretion rate, which were blocked by doxazosin. These data suggest that acute decreases, but not increases, in sIgA are mediated by alpha‐adrenergic mechanisms.
Original languageEnglish
Pages (from-to)634-643
Number of pages10
JournalPsychophysiology
Volume37
Issue number5
DOIs
Publication statusPublished - Sep 2000
Externally publishedYes

Keywords

  • Alpha‐adrenoceptor blockade
  • Cardiovascular activity
  • Cold pressor
  • Doxazosin
  • Exercise
  • Mental arithmetic
  • Secretory immunoglobulin A

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