S-acylation by the DHHC protein family

Jennifer Greaves; Luke H Chamberlain

doi:10.1042/BST0380522

S-acylation by the DHHC protein family

Jennifer Greaves, Luke H Chamberlain

University of Edinburgh

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

A family of 23 DHHC (Asp-His-His-Cys) proteins that function as mammalian S-acyltransferases has been identified, reinvigorating the study of protein S-acylation. Recent studies have continued to reveal how S-acylation affects target proteins, and have provided glimpses of how DHHC-substrate specificity might be achieved.

Original language	English
Pages (from-to)	522-524
Number of pages	3
Journal	Biochemical Society Transactions
Volume	38
Issue number	2
DOIs	https://doi.org/10.1042/BST0380522
Publication status	Published - 1 Apr 2010
Externally published	Yes

Keywords

Acylation
Acyltransferases
Animals
Catalysis
Humans
Membrane Proteins
Multigene Family
Proteins
Substrate Specificity
Tissue Distribution
Journal Article
Research Support, Non-U.S. Gov't
Review

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10.1042/BST0380522

Cite this

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abstract = "A family of 23 DHHC (Asp-His-His-Cys) proteins that function as mammalian S-acyltransferases has been identified, reinvigorating the study of protein S-acylation. Recent studies have continued to reveal how S-acylation affects target proteins, and have provided glimpses of how DHHC-substrate specificity might be achieved.",

keywords = "Acylation, Acyltransferases, Animals, Catalysis, Humans, Membrane Proteins, Multigene Family, Proteins, Substrate Specificity, Tissue Distribution, Journal Article, Research Support, Non-U.S. Gov't, Review",

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AU - Greaves, Jennifer

AU - Chamberlain, Luke H

PY - 2010/4/1

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N2 - A family of 23 DHHC (Asp-His-His-Cys) proteins that function as mammalian S-acyltransferases has been identified, reinvigorating the study of protein S-acylation. Recent studies have continued to reveal how S-acylation affects target proteins, and have provided glimpses of how DHHC-substrate specificity might be achieved.

AB - A family of 23 DHHC (Asp-His-His-Cys) proteins that function as mammalian S-acyltransferases has been identified, reinvigorating the study of protein S-acylation. Recent studies have continued to reveal how S-acylation affects target proteins, and have provided glimpses of how DHHC-substrate specificity might be achieved.

KW - Acylation

KW - Acyltransferases

KW - Animals

KW - Catalysis

KW - Humans

KW - Membrane Proteins

KW - Multigene Family

KW - Proteins

KW - Substrate Specificity

KW - Tissue Distribution

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1042/BST0380522

DO - 10.1042/BST0380522

M3 - Review article

C2 - 20298214

SN - 0300-5127

VL - 38

SP - 522

EP - 524

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 2

ER -

S-acylation by the DHHC protein family

Abstract

Keywords

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