Role of endothelium in ischaemia-induced myocardial dysfunction of isolated working hearts: cardioprotection by activation of adenosine A2A receptors

H.L. Maddock; K.J. Broadley; A. Bril; N. Khandoudi

doi:10.1046/j.1365-2680.2001.00238.x

Role of endothelium in ischaemia-induced myocardial dysfunction of isolated working hearts: cardioprotection by activation of adenosine A2A receptors

H.L. Maddock
, K.J. Broadley
, A. Bril
, N. Khandoudi

Cardiff University
GlaxoSmithKline Laboratoires Pharmaceutiques

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

This study aimed to determine the role of the vascular endothelium on recovery of contractile function following global low‐flow ischaemia of guinea‐pig isolated working hearts and the effects of adenosine analogues on this recovery.

Original language	English
Pages (from-to)	263-271
Number of pages	9
Journal	Journal of Autonomic Pharmacology
Volume	21
Issue number	5
DOIs	https://doi.org/10.1046/j.1365-2680.2001.00238.x
Publication status	Published - 2001
Externally published	Yes

Keywords

adenosine analogues
A1 and A2‐purinoceptors
endothelium
ischaemia and reperfusion
working heart
cardioprotection

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10.1046/j.1365-2680.2001.00238.x

Cite this

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title = "Role of endothelium in ischaemia-induced myocardial dysfunction of isolated working hearts: cardioprotection by activation of adenosine A2A receptors",

abstract = "This study aimed to determine the role of the vascular endothelium on recovery of contractile function following global low‐flow ischaemia of guinea‐pig isolated working hearts and the effects of adenosine analogues on this recovery.",

keywords = "adenosine analogues, A1 and A2‐purinoceptors, endothelium, ischaemia and reperfusion, working heart, cardioprotection",

author = "H.L. Maddock and K.J. Broadley and A. Bril and N. Khandoudi",

year = "2001",

doi = "10.1046/j.1365-2680.2001.00238.x",

language = "English",

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pages = "263--271",

journal = "Journal of Autonomic Pharmacology",

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T1 - Role of endothelium in ischaemia-induced myocardial dysfunction of isolated working hearts

T2 - cardioprotection by activation of adenosine A2A receptors

AU - Maddock, H.L.

AU - Broadley, K.J.

AU - Bril, A.

AU - Khandoudi, N.

PY - 2001

Y1 - 2001

N2 - This study aimed to determine the role of the vascular endothelium on recovery of contractile function following global low‐flow ischaemia of guinea‐pig isolated working hearts and the effects of adenosine analogues on this recovery.

AB - This study aimed to determine the role of the vascular endothelium on recovery of contractile function following global low‐flow ischaemia of guinea‐pig isolated working hearts and the effects of adenosine analogues on this recovery.

KW - adenosine analogues

KW - A1 and A2‐purinoceptors

KW - endothelium

KW - ischaemia and reperfusion

KW - working heart

KW - cardioprotection

UR - https://www.scopus.com/pages/publications/0035555602

U2 - 10.1046/j.1365-2680.2001.00238.x

DO - 10.1046/j.1365-2680.2001.00238.x

M3 - Article

SN - 1474-8665

VL - 21

SP - 263

EP - 271

JO - Journal of Autonomic Pharmacology

JF - Journal of Autonomic Pharmacology

IS - 5

ER -

Role of endothelium in ischaemia-induced myocardial dysfunction of isolated working hearts: cardioprotection by activation of adenosine A2A receptors

Abstract

Keywords

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