Retinal microvascular associations with cardiometabolic risk factors differ by diabetes status: results from the UK Biobank

Robyn J. Tapp, Christopher G. Owen, Sarah A. Barman, David P. Strachan, Roshan A. Welikala, Paul J. Foster, Peter H. Whincup, Alicja R. Rudnicka

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    Abstract

    Aims/hypothesis
    The aim of the study was to examine the association of retinal vessel morphometry with BP, body composition and biochemistry, and to determine whether these associations differ by diabetes status.

    Methods
    The UK Biobank ocular assessment included 68,550 participants aged 40-70 years who underwent non-mydriatic retinal photography, BP and body composition measurements, and haematological analysis. A fully automated image analysis program provided measurements of retinal vessel diameter and tortuosity. The associations between retinal vessel morphology and cardiometabolic risk factors by diabetes status were examined using multilevel linear regression, to provide absolute differences in vessel diameter and percentage differences in tortuosity (allowing for within-person clustering).

    Results
    A total of 50,233 participants (a reduction from 68,550) were included in these analyses. Overall, those with diabetes had significantly more tortuous venules and wider arteriolar diameters compared with those without. Associations between venular tortuosity and cardiometabolic risk factors differed according to diabetes status (p interaction <0.01) for total fat mass index, HbA1c, C-reactive protein, white cell count and granulocyte count. For example, a unit rise in white cell count was associated with a 0.18% increase (95% CI 0.05, 0.32%) in venular tortuosity for those without diabetes and a 1.48% increase (95% CI 0.90, 2.07%) among those with diabetes. For arteriolar diameter, significant interactions were evident for systolic BP, diastolic BP, mean arterial pressure (MAP) and LDL-cholesterol. For example, a 10 mmHg rise in systolic BP was associated with a −0.92 μm difference (95% CI −0.96 to −0.88 μm) in arteriolar diameter for those without diabetes, and a −0.58 μm difference (95% CI −0.76 to −0.41 μm) among those with diabetes. No interactions were observed for arteriolar tortuosity or venular diameters.

    Conclusions/interpretation
    We provide clear evidence of the modifying effect of diabetes on cardiometabolic risk factor associations with retinal microvascular architecture. These observations suggest the occurrence of preclinical disease processes, and may be a sign of impaired autoregulation due to hyperglycaemia, which has been suggested to play a pivotal role in the development of diabetes-related microvascular complications.
    Original languageEnglish
    Pages (from-to)1652-1663
    Number of pages12
    JournalDiabetologia
    Volume65
    Issue number10
    Early online date19 Jul 2022
    DOIs
    Publication statusPublished - Oct 2022

    Bibliographical note

    Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

    Funder

    Funding Information: The project was funded by a grant from the British Heart Foundation (PG/15/101/31889). The research was performed using the UK Biobank Resource under Application Number 522. The list of UK Biobank Eye and Vision Consortium members is available from the consortium website
    (http://www.ukbiobankeyeconsortium.org.uk/people ).

    Keywords

    • Cardiometabolic risk
    • Diabetes
    • Diameters
    • Epidemiology
    • Retinal imaging
    • Retinal microvasculature
    • Tortuosity

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism

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