Abstract
OBJECTIVE: To examine the relationship of retinal vascular caliber to incident diabetes in a population-based cohort.
RESEARCH DESIGN AND METHODS: The Australian Diabetes, Obesity and Lifestyle (AusDiab) Study recruited adults aged 25+ years across Australia in 1999-2000, with a follow-up 5 years later in 2004-2005. Participants' glycemic status was classified using fasting plasma glucose (FPG) and 2-h oral glucose tolerance (2-h plasma glucose [2hPG]) tests. Diabetes was diagnosed if FPG was >or=7.0 mmol/l or 2hPG was >or=11.1 mmol/l. Retinal vascular caliber was measured from baseline retinal photographs using a computer-assisted program.
RESULTS: Of the 803 participants without diabetes at baseline, 108 (13.4%) developed diabetes at follow-up: 7 (2.8%) of 246 participants with normal glucose tolerance, 9 (13.6%) of 66 participants with impaired fasting glucose, and 92 (18.7%) of 491 participants with impaired glucose tolerance. After multivariate analysis, participants with narrower retinal arteriolar caliber had a higher risk of diabetes (odds ratio 2.21 [95% CI 1.02-4.80], comparing smallest versus highest arteriolar caliber tertiles, P = 0.04 for trend). There was no association between retinal venular caliber and incident diabetes.
CONCLUSIONS: Narrower retinal arteriolar caliber predicted risk of diabetes. These data provide further evidence that microvascular changes may contribute to the pathogenesis of diabetes.
Original language | English |
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Pages (from-to) | 536-539 |
Number of pages | 4 |
Journal | Diabetes Care |
Volume | 57 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2008 |
Externally published | Yes |
Keywords
- Adult
- Aged
- Australia/epidemiology
- Diabetes Mellitus/epidemiology
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Obesity/epidemiology
- Odds Ratio
- Retinal Artery Occlusion/complications
- Risk Factors