Resistance training promotes reduction in Visceral Adiposity without improvements in Cardiomyocyte Contractility and Calcium handling in Obese Rats

Alexandre Barroso, Andressa Prata Leite Damiani, Priscila Murucci Coelho, Arícia Leone Evangelista Monteiro de Assis, Breno Valentim Nogueira, Lucas Guimarães Ferreira, Richard Diego Leite, Rogério Faustino Ribeiro Júnior, Ana Paula Lima-Leopoldo, André Soares Leopoldo

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
7 Downloads (Pure)


Resistance training (RT) improves the cardiomyocyte calcium (Ca2+) cycling during excitation-contraction coupling. However, the role of RT in cardiomyocyte contractile function associated with Ca2+ handling in obesity is unclear. Wistar rats were distributed into four groups: control, sedentary obese, control plus RT, and obesity plus RT. The 10-wk RT protocol was used (4-5 vertical ladder climbs, 60-second interval, 3× a week, 50-100% of maximum load). Metabolic, hormonal, cardiovascular and biochemical parameters were determined. Reduced leptin levels, epididymal, retroperitoneal and visceral fat pads, lower body fat, and adiposity index were observed in RT. Obesity promoted elevation of collagen, but RT did not promote modifications of LV collagen in ObRT. RT induced elevation in maximum rates of contraction and relaxation, and reduction of time to 50% relaxation. ObRT group did not present improvement in the cardiomyocyte contractile function in comparison to Ob group. Reduced cardiac PLB serine16 phosphorylation (pPLB Ser16) and pPLB Ser16/PLB ratio with no alterations in sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) and phospholamban (PLB) expression were observed in Ob groups. Resistance training improved body composition reduced fat pads and plasma leptin levels but did not promote positive alterations in cardiomyocyte contractile function, Ca2+ handling and phospholamban phosphorylation.

Original languageEnglish
Pages (from-to)1819-1832
Number of pages14
JournalInternational Journal of Medical Sciences
Issue number12
Publication statusPublished - 11 Jul 2020
Externally publishedYes

Bibliographical note

This is an open access article distributed under the terms of the Creative Commons Attribution License ( See for full terms and conditions.


This work was supported by Fundação de Amparo à Pesquisa e Inovação do Espírito Santo - FAPES (grant number: 74434489/16) and partially financed by the Coordination for Improvement of Higher Education Personnel – Brazil (CAPES) - Finance Code 001.


  • Calcium metabolism
  • Myocites
  • Myocardial Contraction
  • Adiposity
  • Resistance Training
  • Obesity
  • Contractile function
  • High-fat diet
  • Resistance training
  • Calcium handling

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Resistance training promotes reduction in Visceral Adiposity without improvements in Cardiomyocyte Contractility and Calcium handling in Obese Rats'. Together they form a unique fingerprint.

Cite this