Relationship between heart rate variability and echocardiography indices of cardiac function in healthy individuals

Mushidur Rahman; Sophie L. Russell; Nduka C. Okwose; Charles J. Steward; Helen Maddock; Prithwish Banerjee; Prithwish Banerjee; Djordje Jakovljevic

doi:10.1111/cpf.12910

Relationship between heart rate variability and echocardiography indices of cardiac function in healthy individuals

Mushidur Rahman, Sophie L. Russell, Nduka C. Okwose, Charles J. Steward, Helen Maddock, Prithwish Banerjee, Prithwish Banerjee, Djordje Jakovljevic

University Hospitals Coventry and Warwickshire NHS Trust

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Abstract

Purpose: This study evaluated the relationship between HRV and echocardiography indices of cardiac function. Methods: Healthy individuals (N = 30) aged 33 ± 10 years old, underwent short‐term resting HRV assessment and transthoracic echocardiography with speckle tracking analysis. Time domain ‐ (i.e. R‐R interval, root mean square of successive RR interval difference (RMSSD), standard deviation of normal RR intervals (SDNN) and frequency domain‐measures of HRV (i.e. high‐frequency power (HF), low‐frequency power (LF), high‐frequency normalised (HFnorm) and low‐frequency normalised (LFnorm)). Echocardiography indices of cardiac function included; Left ventricular ejection fraction (LVEF), left‐ and right‐ventricular global longitudinal strain (LV‐GLS, and RV GLS), left atrial strain: left atrial reservoir (LAres), left atrial conduit (LAcon) and left atrial contraction (LACT). Results: The mean values for HRV time‐domain measures were: R‐R (991 ± 176 ms), SDNN (50.9 ± 21.5 ms), and RMSSD (46.8 ± 29.4 ms); and frequency‐domain: LF (727 ± 606 ms2), HF (415 ± 35 ms2), LFnorm (56 ± 19.4) and HFnorm (36.5 ± 18.8). Mean values for indices of cardiac function were LVEF (59.9% ± 2.8%), LV‐GLS (19.2% ± 1.4%), RV‐GLS (21.7% ± 2.7%), LAres (36.8% ± 6.99%), LAcon (26.2% ± 6.95%) and LACT (12.3% ± 3.56%). There was a significant negative relationship between HF and LV‐GLS (r = −0.47, p = 0.01) and RMSSD and LVEF (r = −0.39, p = 0.03) respectively. Conclusion: Heart rate variability measures such as high frequency power and RMSSD are associated with left ventricle systolic function in healthy individuals.

Original language	English
Pages (from-to)	(In-Press)
Number of pages	7
Journal	Clinical Physiology and Functional Imaging
Volume	(In-Press)
Early online date	5 Nov 2024
DOIs	https://doi.org/10.1111/cpf.12910
Publication status	E-pub ahead of print - 5 Nov 2024

Bibliographical note

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Keywords

heart rate variability
speckle tracking echocardiography
echocardiography

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10.1111/cpf.12910Licence: CC BY

Rahman2024VORFinal published version, 646 KBLicence: CC BY

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Rahman, M., Russell, S. L., Okwose, N. C., Steward, C. J., Maddock, H., Banerjee, P., Banerjee, P., & Jakovljevic, D. (2024). Relationship between heart rate variability and echocardiography indices of cardiac function in healthy individuals. Clinical Physiology and Functional Imaging, (In-Press), (In-Press). Advance online publication. https://doi.org/10.1111/cpf.12910

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title = "Relationship between heart rate variability and echocardiography indices of cardiac function in healthy individuals",

abstract = "Purpose: This study evaluated the relationship between HRV and echocardiography indices of cardiac function. Methods: Healthy individuals (N = 30) aged 33 ± 10 years old, underwent short‐term resting HRV assessment and transthoracic echocardiography with speckle tracking analysis. Time domain ‐ (i.e. R‐R interval, root mean square of successive RR interval difference (RMSSD), standard deviation of normal RR intervals (SDNN) and frequency domain‐measures of HRV (i.e. high‐frequency power (HF), low‐frequency power (LF), high‐frequency normalised (HFnorm) and low‐frequency normalised (LFnorm)). Echocardiography indices of cardiac function included; Left ventricular ejection fraction (LVEF), left‐ and right‐ventricular global longitudinal strain (LV‐GLS, and RV GLS), left atrial strain: left atrial reservoir (LAres), left atrial conduit (LAcon) and left atrial contraction (LACT). Results: The mean values for HRV time‐domain measures were: R‐R (991 ± 176 ms), SDNN (50.9 ± 21.5 ms), and RMSSD (46.8 ± 29.4 ms); and frequency‐domain: LF (727 ± 606 ms2), HF (415 ± 35 ms2), LFnorm (56 ± 19.4) and HFnorm (36.5 ± 18.8). Mean values for indices of cardiac function were LVEF (59.9% ± 2.8%), LV‐GLS (19.2% ± 1.4%), RV‐GLS (21.7% ± 2.7%), LAres (36.8% ± 6.99%), LAcon (26.2% ± 6.95%) and LACT (12.3% ± 3.56%). There was a significant negative relationship between HF and LV‐GLS (r = −0.47, p = 0.01) and RMSSD and LVEF (r = −0.39, p = 0.03) respectively. Conclusion: Heart rate variability measures such as high frequency power and RMSSD are associated with left ventricle systolic function in healthy individuals.",

keywords = "heart rate variability, speckle tracking echocardiography, echocardiography",

author = "Mushidur Rahman and Russell, {Sophie L.} and Okwose, {Nduka C.} and Steward, {Charles J.} and Helen Maddock and Prithwish Banerjee and Prithwish Banerjee and Djordje Jakovljevic",

note = "This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.",

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doi = "10.1111/cpf.12910",

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TY - JOUR

T1 - Relationship between heart rate variability and echocardiography indices of cardiac function in healthy individuals

AU - Rahman, Mushidur

AU - Russell, Sophie L.

AU - Okwose, Nduka C.

AU - Steward, Charles J.

AU - Maddock, Helen

AU - Banerjee, Prithwish

AU - Jakovljevic, Djordje

N1 - This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PY - 2024/11/5

Y1 - 2024/11/5

N2 - Purpose: This study evaluated the relationship between HRV and echocardiography indices of cardiac function. Methods: Healthy individuals (N = 30) aged 33 ± 10 years old, underwent short‐term resting HRV assessment and transthoracic echocardiography with speckle tracking analysis. Time domain ‐ (i.e. R‐R interval, root mean square of successive RR interval difference (RMSSD), standard deviation of normal RR intervals (SDNN) and frequency domain‐measures of HRV (i.e. high‐frequency power (HF), low‐frequency power (LF), high‐frequency normalised (HFnorm) and low‐frequency normalised (LFnorm)). Echocardiography indices of cardiac function included; Left ventricular ejection fraction (LVEF), left‐ and right‐ventricular global longitudinal strain (LV‐GLS, and RV GLS), left atrial strain: left atrial reservoir (LAres), left atrial conduit (LAcon) and left atrial contraction (LACT). Results: The mean values for HRV time‐domain measures were: R‐R (991 ± 176 ms), SDNN (50.9 ± 21.5 ms), and RMSSD (46.8 ± 29.4 ms); and frequency‐domain: LF (727 ± 606 ms2), HF (415 ± 35 ms2), LFnorm (56 ± 19.4) and HFnorm (36.5 ± 18.8). Mean values for indices of cardiac function were LVEF (59.9% ± 2.8%), LV‐GLS (19.2% ± 1.4%), RV‐GLS (21.7% ± 2.7%), LAres (36.8% ± 6.99%), LAcon (26.2% ± 6.95%) and LACT (12.3% ± 3.56%). There was a significant negative relationship between HF and LV‐GLS (r = −0.47, p = 0.01) and RMSSD and LVEF (r = −0.39, p = 0.03) respectively. Conclusion: Heart rate variability measures such as high frequency power and RMSSD are associated with left ventricle systolic function in healthy individuals.

AB - Purpose: This study evaluated the relationship between HRV and echocardiography indices of cardiac function. Methods: Healthy individuals (N = 30) aged 33 ± 10 years old, underwent short‐term resting HRV assessment and transthoracic echocardiography with speckle tracking analysis. Time domain ‐ (i.e. R‐R interval, root mean square of successive RR interval difference (RMSSD), standard deviation of normal RR intervals (SDNN) and frequency domain‐measures of HRV (i.e. high‐frequency power (HF), low‐frequency power (LF), high‐frequency normalised (HFnorm) and low‐frequency normalised (LFnorm)). Echocardiography indices of cardiac function included; Left ventricular ejection fraction (LVEF), left‐ and right‐ventricular global longitudinal strain (LV‐GLS, and RV GLS), left atrial strain: left atrial reservoir (LAres), left atrial conduit (LAcon) and left atrial contraction (LACT). Results: The mean values for HRV time‐domain measures were: R‐R (991 ± 176 ms), SDNN (50.9 ± 21.5 ms), and RMSSD (46.8 ± 29.4 ms); and frequency‐domain: LF (727 ± 606 ms2), HF (415 ± 35 ms2), LFnorm (56 ± 19.4) and HFnorm (36.5 ± 18.8). Mean values for indices of cardiac function were LVEF (59.9% ± 2.8%), LV‐GLS (19.2% ± 1.4%), RV‐GLS (21.7% ± 2.7%), LAres (36.8% ± 6.99%), LAcon (26.2% ± 6.95%) and LACT (12.3% ± 3.56%). There was a significant negative relationship between HF and LV‐GLS (r = −0.47, p = 0.01) and RMSSD and LVEF (r = −0.39, p = 0.03) respectively. Conclusion: Heart rate variability measures such as high frequency power and RMSSD are associated with left ventricle systolic function in healthy individuals.

KW - heart rate variability

KW - speckle tracking echocardiography

KW - echocardiography

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U2 - 10.1111/cpf.12910

DO - 10.1111/cpf.12910

M3 - Article

SN - 1475-0961

VL - (In-Press)

SP - (In-Press)

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

ER -

Relationship between heart rate variability and echocardiography indices of cardiac function in healthy individuals

Abstract

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