Relationship between Body Mass Index, Risk of Venous thromboembolism and Pulmonary Embolism: a systematic review and dose-response meta-analysis of cohort studies among four million participants

Jamal Rahmani, Arezoo Haghighian Roudsari, Hiba Bawadi, Jacqueline Thomps, Razieh Khalooei Fard, Cain Clark, Paul Ryan, Marjan Ajami, Fatemeh Rahimi sakak, Ammar Salehisahlabadi, Hebatullah M Abdulazeem, Mohammad Reza Jamali, Jalaledin Mirzay Razaz

    Research output: Contribution to journalReview articlepeer-review

    7 Citations (Scopus)
    16 Downloads (Pure)

    Abstract

    Background: The relationship between body mass index (BMI) and risk of venous thromboembolism (VTE) and pulmonary embolism (PE) is a controversial issue. This dose-response meta-analysis was performed to investigate the association between BMI and risk of VTE and PE incidence based on cohort studies. Method: A comprehensive systematic search was conducted up to August 2019 in MEDLINE/PubMed, SCOPUS, and Cochrane. DerSimonian and Laird random-effects models were run to estimate combined hazard ratios (HRs) with 95% confidence intervals (CIs). Dose-response analysis was also carried out based on BMI values. Results: Eleven articles with 16 arms and 3,910,747 participants were eligible for inclusion in this systematic review and meta-analysis. Pooled results showed a positive association between BMI and risk of VTE in the obese participants compared to participants classified in the normal BMI category (HR: 1.62, 95% CI: 1.29–2.04, I 2 = 95%). Furthermore, results showed a significant association between lower BMI (underweight versus normal BMI category) and reduced risk of PE (HR: 0.80, 95% CI: 0.70–0.92, I 2 = 9%) and higher risk of PE in obese versus normal BMI participants (HR: 2.24, 95% CI: 1.93–2.60, I 2 = 0%). There was a significant linear relationship between BMI and risk of VTE (p < 0.001) and PE (p < 0.001). Conclusions: This systematic review and dose-response meta-analysis with 3,910,747 participants highlights obesity as a significant risk factor related to the incidence of VTE and PE.

    Original languageEnglish
    Pages (from-to)64-72
    Number of pages9
    JournalThrombosis Research
    Volume192
    Early online date15 May 2020
    DOIs
    Publication statusPublished - Aug 2020

    Bibliographical note

    NOTICE: this is the author’s version of a work that was accepted for publication in Thrombosis Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Thrombosis Research, 192, (2020) DOI: 10.1016/j.thromres.2020.05.014

    © 2020, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

    Keywords

    • Body mass index
    • Pulmonary embolism
    • Venous thromboembolism

    ASJC Scopus subject areas

    • Hematology

    Fingerprint

    Dive into the research topics of 'Relationship between Body Mass Index, Risk of Venous thromboembolism and Pulmonary Embolism: a systematic review and dose-response meta-analysis of cohort studies among four million participants'. Together they form a unique fingerprint.

    Cite this