Regional variations in the prevalence and misdiagnosis of air flow obstruction in China: baseline results from a prospective cohort of the China Kadoorie Biobank (CKB)

Om Kurmi, Liming Li, Margaret Smith, Mareli Augustyn, Junshi Chen, Rory Collins, Yu Guo, Yabin Han, Jingxin Qin, Guanqun Xu, Jian Wang, Zheng Bian, Gang Zhou, Kourtney Davis, Richard Peto, Zhenming Chen, Liming Li, Zhengming Chen, Junshi Chen, Rory CollinsRichard Peto, Zhengming Chen, Garry Lancaster, Xiaoming Yang, Alex Williams, Margaret Smith, Ling Yang, Yumei Chang, Iona Millwood, Yiping Chen, Sarah Lewington, Sam Sansome, Robin Walters, Om Kurmi, Yu Guo, Zheng Bian, Can Hou, Yunlong Tan, Zheng Wang, Xin Cai, Huiyan Zhou, Xuguan Chen, Zengchang Pang, Shanpeng Li, Shaojie Wang, Silu Lv, Zhonghou Zhao, Shumei Liu, Zhigang Pang, Liqiu Yang

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Abstract

BACKGROUND: Despite the great burden of chronic respiratory diseases in China, few large multicentre, spirometry-based studies have examined its prevalence, rate of underdiagnosis regionally or the relevance of socioeconomic and lifestyle factors.

METHODS: We analysed data from 512 891 adults in the China Kadoorie Biobank, recruited from 10 diverse regions of China during 2004-2008. Air flow obstruction (AFO) was defined by the lower limit of normal criteria based on spirometry-measured lung function. The prevalence of AFO was analysed by region, age, socioeconomic status, body mass index (BMI) and smoking history and compared with the prevalence of self-reported physician-diagnosed chronic bronchitis or emphysema (CB/E) and its symptoms.

FINDINGS: The prevalence of AFO was 7.3% in men (range 2.5-18.2%) and 6.4% in women (1.5-18.5%). Higher prevalence of AFO was associated with older age (p<0.0001), lower income (p<0.0001), poor education (p<0.001), living in rural regions (p<0.001), those who started smoking before the age of 20 years (p<0.001) and low BMI (p<0.001). Compared with self-reported diagnosis of CB/E, 88.8% of AFO was underdiagnosed; underdiagnosis proportion was highest in 30-39-year olds (96.7%) compared with the 70+ age group (81.1%), in women (90.7%), in urban areas (89.4%), in people earning 5K-10 K ¥ monthly (90.3%) and in those with middle or high school education (92.6%).

INTERPRETATION: In China, the burden of AFO based on spirometry was high and significantly greater than that estimated based on self-reported physician-diagnosed CB/E, especially in rural areas, reflecting major issues with diagnosis of AFO that will impact disease treatment and management.

Original languageEnglish
Article numbere000025
Number of pages19
JournalBMJ open respiratory research
Volume1
Issue number1
DOIs
Publication statusPublished - 9 May 2014
Externally publishedYes

Bibliographical note

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

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