Receptor activity modifying proteins and their potential as drug targets

Denise L. Wootten; John Simms; Debbie L. Hay; Arthur Christopoulos; Patrick M. Sexton

doi:10.1016/S1877-1173(10)91003-X

Receptor activity modifying proteins and their potential as drug targets

Denise L. Wootten, John Simms, Debbie L. Hay, Arthur Christopoulos, Patrick M. Sexton

School of Nursing, Midwifery and Health

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

The receptor activity modifying proteins (RAMPs) are a family of membrane proteins that interact with some G protein-coupled receptors (GPCRs) to regulate their function. RAMPs can alter GPCR pharmacology and can regulate their signaling as well as trafficking to and from the cell surface. GPCRs have been successfully exploited as drug targets for many years. RAMPs therefore provide a new avenue for drug development, offering opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. RAMPs could be directly targeted themselves or advantage could be taken of the unique RAMP/GPCR interfaces for generating more selective drugs.

Original language	English
Pages (from-to)	53-79
Number of pages	27
Journal	Progress in Molecular Biology and Translational Science
Volume	91
DOIs	https://doi.org/10.1016/S1877-1173(10)91003-X
Publication status	Published - 5 Aug 2010

Keywords

Amino Acid Sequence
Animals
Drug Discovery
Glycosylation
Humans
Intracellular Signaling Peptides and Proteins
Membrane Proteins
Molecular Sequence Data
Multiprotein Complexes
Receptor Activity-Modifying Proteins
Receptors, G-Protein-Coupled
Sequence Homology, Amino Acid
Signal Transduction
Journal Article
Review

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10.1016/S1877-1173(10)91003-X

Cite this

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title = "Receptor activity modifying proteins and their potential as drug targets",

abstract = "The receptor activity modifying proteins (RAMPs) are a family of membrane proteins that interact with some G protein-coupled receptors (GPCRs) to regulate their function. RAMPs can alter GPCR pharmacology and can regulate their signaling as well as trafficking to and from the cell surface. GPCRs have been successfully exploited as drug targets for many years. RAMPs therefore provide a new avenue for drug development, offering opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. RAMPs could be directly targeted themselves or advantage could be taken of the unique RAMP/GPCR interfaces for generating more selective drugs.",

keywords = "Amino Acid Sequence, Animals, Drug Discovery, Glycosylation, Humans, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Molecular Sequence Data, Multiprotein Complexes, Receptor Activity-Modifying Proteins, Receptors, G-Protein-Coupled, Sequence Homology, Amino Acid, Signal Transduction, Journal Article, Review",

author = "Wootten, {Denise L.} and John Simms and Hay, {Debbie L.} and Arthur Christopoulos and Sexton, {Patrick M.}",

year = "2010",

month = aug,

day = "5",

doi = "10.1016/S1877-1173(10)91003-X",

language = "English",

volume = "91",

pages = "53--79",

journal = "Progress in Molecular Biology and Translational Science",

issn = "1877-1173",

publisher = "Academic Press",

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TY - JOUR

T1 - Receptor activity modifying proteins and their potential as drug targets

AU - Wootten, Denise L.

AU - Simms, John

AU - Hay, Debbie L.

AU - Christopoulos, Arthur

AU - Sexton, Patrick M.

PY - 2010/8/5

Y1 - 2010/8/5

N2 - The receptor activity modifying proteins (RAMPs) are a family of membrane proteins that interact with some G protein-coupled receptors (GPCRs) to regulate their function. RAMPs can alter GPCR pharmacology and can regulate their signaling as well as trafficking to and from the cell surface. GPCRs have been successfully exploited as drug targets for many years. RAMPs therefore provide a new avenue for drug development, offering opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. RAMPs could be directly targeted themselves or advantage could be taken of the unique RAMP/GPCR interfaces for generating more selective drugs.

AB - The receptor activity modifying proteins (RAMPs) are a family of membrane proteins that interact with some G protein-coupled receptors (GPCRs) to regulate their function. RAMPs can alter GPCR pharmacology and can regulate their signaling as well as trafficking to and from the cell surface. GPCRs have been successfully exploited as drug targets for many years. RAMPs therefore provide a new avenue for drug development, offering opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. RAMPs could be directly targeted themselves or advantage could be taken of the unique RAMP/GPCR interfaces for generating more selective drugs.

KW - Amino Acid Sequence

KW - Animals

KW - Drug Discovery

KW - Glycosylation

KW - Humans

KW - Intracellular Signaling Peptides and Proteins

KW - Membrane Proteins

KW - Molecular Sequence Data

KW - Multiprotein Complexes

KW - Receptor Activity-Modifying Proteins

KW - Receptors, G-Protein-Coupled

KW - Sequence Homology, Amino Acid

KW - Signal Transduction

KW - Journal Article

KW - Review

U2 - 10.1016/S1877-1173(10)91003-X

DO - 10.1016/S1877-1173(10)91003-X

M3 - Review article

C2 - 20691959

SN - 1877-1173

VL - 91

SP - 53

EP - 79

JO - Progress in Molecular Biology and Translational Science

JF - Progress in Molecular Biology and Translational Science

ER -

Receptor activity modifying proteins and their potential as drug targets

Abstract

Keywords

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