Receptor activity modifying proteins and their potential as drug targets

Denise L. Wootten, John Simms, Debbie L. Hay, Arthur Christopoulos, Patrick M. Sexton

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

The receptor activity modifying proteins (RAMPs) are a family of membrane proteins that interact with some G protein-coupled receptors (GPCRs) to regulate their function. RAMPs can alter GPCR pharmacology and can regulate their signaling as well as trafficking to and from the cell surface. GPCRs have been successfully exploited as drug targets for many years. RAMPs therefore provide a new avenue for drug development, offering opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. RAMPs could be directly targeted themselves or advantage could be taken of the unique RAMP/GPCR interfaces for generating more selective drugs.

Original languageEnglish
Pages (from-to)53-79
Number of pages27
JournalProgress in Molecular Biology and Translational Science
Volume91
DOIs
Publication statusPublished - 5 Aug 2010

Keywords

  • Amino Acid Sequence
  • Animals
  • Drug Discovery
  • Glycosylation
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Molecular Sequence Data
  • Multiprotein Complexes
  • Receptor Activity-Modifying Proteins
  • Receptors, G-Protein-Coupled
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Journal Article
  • Review

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