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Recent Advances in AI and GenAI for Health Informatics

  • Sio Iong Ao
  • , Vasile Palade
  • , Chris Holt
  • , Suzy Araujo
  • , Mike Gourlay
  • , Danina Kapetanovic
  • International Association of Engineers (IAENG)
  • University of Waterloo
  • Waterloo Regional Health Network

Research output: Contribution to journalReview articlepeer-review

22 Downloads (Pure)

Abstract

The emergence of large language models (LLMs) and generative artificial intelligence (GenAI) has marked a turning point in health informatics. AI has become a very helpful tool for health informatics applications, with numerous AI applications in health informatics being reported in the last years. The objective of this paper is to synthesize the common concerns and opportunities raised by recent popular reviews on AI and health informatics. The main methodological topics covered in this up-to-date review include traditional AI, GenAI, and LLMs. The literature search was conducted through the popular academic database Scopus, which covers over one hundred million records, including both computer science and healthcare. Among these popular reviews (measured by the number of citations that each one received), clinical decision support, patient care, electronic health records, hospital management, and remote patient monitoring are the most mentioned healthcare topics. Different from the majority of the existing reviews that narrowly cover on one to a few topics in healthcare, our review is designed with the objective to provide a broad coverage, such that practitioners may benefit from comprehensive insights covering the above mentioned five popular topics in AI health informatics applications. Based on an in-depth analysis of these reviews by human experts, the main AI tools used, their main challenges, and some future directions have been identified in our investigation. Patient privacy, cybersecurity, ethics, clinical accountability, engaging health professionals, benchmarks and standardization, as well as lack of explainability are the common concerns identified from the literature covered in this review.
Original languageEnglish
Article number495
Number of pages46
JournalHealthcare
Volume14
Issue number4
DOIs
Publication statusPublished - 14 Feb 2026

Bibliographical note

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • artificial intelligence
  • clinical decision support
  • electronic health records
  • generative AI
  • health analytics
  • health informatics
  • hospital management
  • large language models
  • patient care
  • remote patient monitoring

ASJC Scopus subject areas

  • Leadership and Management
  • Health Policy
  • Health Informatics
  • Health Information Management

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