RAMPs as drug targets

Patrick M Sexton, David R Poyner, John Simms, Arthur Christopoulos, Debbie L Hay

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Citations (Scopus)

Abstract

The receptor activity-modifying protein (RAMP) family of membrane proteins regulates G protein-coupled receptor (GPCR) function in several ways. RAMPs can alter their pharmacology and signalling as well as the trafficking of these receptors to and from the cell surface. Accordingly, RAMPs may be exploited as drug targets, offering new opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. For example, several small molecule antagonists of RAMP1/ calcitonin receptor-like receptor complexes, which block the actions of the neuropeptide calcitonin gene-related peptide are in development for the treatment of migraine headache.

Original languageEnglish
Title of host publicationRAMPS
EditorsWilliam S. Spielman, Narayanan Parameswaran
PublisherSpringer
Pages61-74
Number of pages14
ISBN (Electronic)9781461423638
DOIs
Publication statusPublished - 2012

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer
Volume744

Keywords

  • Receptor Activity-Modifying Proteins
  • Receptors, G-Protein-Coupled
  • Signal Transduction
  • Journal Article
  • Review

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  • Cite this

    Sexton, P. M., Poyner, D. R., Simms, J., Christopoulos, A., & Hay, D. L. (2012). RAMPs as drug targets. In W. S. Spielman, & N. Parameswaran (Eds.), RAMPS (pp. 61-74). (Advances in Experimental Medicine and Biology; Vol. 744). Springer. https://doi.org/10.1007/978-1-4614-2364-5_6