Quercetin as an Anticancer Agent: Focus on Esophageal Cancer

Amirhossein Davoodvandi, Mohammad Shabani Varkani, Cain Clark, Sadegh Jafarnejad

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Esophageal cancer (EC) is regarded as the sixth highest contributor to all cancer-related mortality, worldwide. In spite of advances in the treatment of EC, currently used methods remain ineffective. Quercetin, as a dietary antioxidant, is a plant flavonol from the flavonoid group of polyphenols, and can be found in numerous vegetables, fruits, and herbs. Quercetin can affect the processes of cancer-related diseases via cell proliferation inhibitory effects, potential apoptosis effects, and antioxidant properties. Of the various types of cancer, the use of quercetin has now become prominent in the treatment of EC. In this review, we discuss how quercetin may be an important supplement for the prevention, treatment, and management of EC, owing to its natural origin, and low-cost relative to synthetic cancer drugs. However, most findings cited in the current study are based on in vitro and in vivo studies, and thus, further human-based research is necessitated. Practical applications: In spite of advances in the treatment of esophageal cancer, currently used methods remain ineffective, therefore, an alternative or complementary therapy is required. Quercetin, as a dietary antioxidant, can affect the processes of cancer-related diseases via cell proliferation inhibitory effects, potential proapoptotic functions, and antioxidant properties. Quercetin may be an important supplement for the prevention, treatment, and management of EC, owing to its natural origin. The low cost of quercetin as supplement or dietary intake, relative to synthetic cancer drugs, is an advantage of the compound which should be considered.

Original languageEnglish
Article numbere13374
Pages (from-to)(In-press)
JournalJournal of Food Biochemistry
Volume44
Issue number9
Early online date19 Jul 2020
DOIs
Publication statusPublished - 1 Sep 2020

Keywords

  • anti-oxidant
  • apoptosis
  • esophageal cancer
  • flavonoid
  • quercetin

ASJC Scopus subject areas

  • Food Science
  • Biophysics
  • Pharmacology
  • Cell Biology

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  • Cite this

    Davoodvandi, A., Varkani, M. S., Clark, C., & Jafarnejad, S. (2020). Quercetin as an Anticancer Agent: Focus on Esophageal Cancer. Journal of Food Biochemistry, 44(9), (In-press). [e13374]. https://doi.org/10.1111/jfbc.13374