Quality of life in patients with intermittent claudication

A. E. Harwood, J. P. Totty, E. Broadbent, George E. Smith, I. C. Chetter

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Intermittent claudication (IC) is a common condition that causes pain in the lower limbs when walking and has been shown to severely impact the quality of life (QoL) of patients. The QoL is therefore often regarded as an important measure in clinical trials investigating intermittent claudication. To date, no consensus exits on the type of life questionnaire to be used. This review aims to examine the QoL questionnaires used in trials investigating peripheral arterial disease (PAD). Material and methods: A systematic review of randomised clinical trials including a primary analysis of QoL via questionnaire was performed. Trials involving patients with diagnosed PAD were included (either clinically or by questionnaire). Any trial which had QoL as the primary outcome data was included with no limit being placed on the type of questionnaire used. Results: The search yielded a total of 1845 articles of which 31 were deemed appropriate for inclusion in the review. In total, 14 different QoL questionnaires were used across 31 studies. Of the questionnaires 24.06% were missing at least one domain when reported in the results of the study. Mean standard deviation varied widely based on the domain reported, particularly within the SF36. Discussion: Despite previous recommendations for Europewide standardisation of quality of life assessment, to date no such tool exists. This review demonstrated that a number of different questionnaires remain in use, that their completion is often inadequate and that further evidence-based guidelines on QoL assessment are required to guide future research.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalGefasschirurgie
Volume22
DOIs
Publication statusPublished - 1 May 2017
Externally publishedYes

Bibliographical note

Open Access. Thisarticleisdistributedunder the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the
source, provide a link to the Creative Commons license, and indicate if changes were made.

Keywords

  • Ankle brachial index
  • Exercise
  • Peripheral arterial disease
  • Questionnaire
  • Review

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Harwood, A. E., Totty, J. P., Broadbent, E., Smith, G. E., & Chetter, I. C. (2017). Quality of life in patients with intermittent claudication. Gefasschirurgie, 22, 159-164. https://doi.org/10.1007/s00772-017-0269-4