Prospective study on physical activity and risk of in situ breast cancer

Karen Steindorf, Rebecca Ritte, Anne Tjonneland, Nina Føns Johnsen, Kim Overvad, Jane Nautrup Østergaard, Françoise Clavel-Chapelon, Agnès Fournier, Laure Dossus, Annekatrin Lukanova, Jenny Chang-Claude, Heiner Boeing, Angelika Wientzek, Antonia Trichopoulou, Tina Karapetyan, Dimitrios Trichopoulos, Giovanna Masala, Vittorio Krogh, Amalia Mattiello, Rosario Tumino & 23 others Silvia Polidoro, José Ramón Quirós, Noémie Travier, María José Sánchez, Carmen Navarro, Eva Ardanaz, Pilar Amiano, H. Bas Bueno-de-Mesquita, Fränzel J B Van Duijnhoven, Evelyn Monninkhof, Anne M. May, Kay Tee Khaw, Nick Wareham, Tim J. Key, Ruth C. Travis, Kristin Benjaminsen Borch, Veronika Fedirko, Sabina Rinaldi, Isabelle Romieu, Petra A. Wark, Teresa Norat, Elio Riboli, Rudolf Kaaks

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Background: Physical activity has been identified as protective factor for invasive breast cancer risk, whereas comparable studies on in situ carcinoma are rare. 

    Methods: The study included data from 283,827 women of the multinational European Prospective Investigation into C7ancer and Nutrition (EPIC)-cohort study. Detailed information on different types of physical activity conducted during the prior year, such as occupational, recreational, and household activity, as well as on important cofactors, was assessed at baseline. Adjusted HRs for in situ breast cancer were estimated by Cox proportional hazards models. 

    Results: During a median follow-up period of 11.7 years, 1,059 incidents of breast carcinoma in situ were identified. In crude and adjusted multivariable models, no associations were found for occupational, household, and recreational physical activity. Furthermore, total physical activity was not associated with risk of in situ breast cancer. Comparing moderately inactive, moderately active, and active participants with inactive study participants resulted in adjusted HRs of 0.99 [95% confidence interval (CI), 0.83-1.19], 0.99 (95% CI, 0.82-1.20), and 1.07 (95% CI, 0.81-1.40), respectively (P value of trend test: 0.788). No inverse associations were found in any substrata defined by age at diagnosis or body mass index (BMI) status. 

    Conclusions: In this large prospective study, we did not find any evidence of an association between physical activity and in situ breast cancer risk. If not by chance, the contrast between our results for carcinoma in situ and the recognized inverse association for invasive breast cancer suggests that physical activity may have stronger effects on proliferation and late stage carcinogenesis.

    Original languageEnglish
    Pages (from-to)2209-2219
    Number of pages11
    JournalCancer Epidemiology Biomarkers and Prevention
    Volume21
    Issue number12
    DOIs
    Publication statusPublished - Dec 2012

    Fingerprint

    Prospective Studies
    Exercise
    Breast Neoplasms
    Carcinoma in Situ
    Confidence Intervals
    Proportional Hazards Models
    Carcinogenesis
    Body Mass Index
    Cohort Studies

    ASJC Scopus subject areas

    • Epidemiology
    • Oncology

    Cite this

    Steindorf, K., Ritte, R., Tjonneland, A., Johnsen, N. F., Overvad, K., Østergaard, J. N., ... Kaaks, R. (2012). Prospective study on physical activity and risk of in situ breast cancer. Cancer Epidemiology Biomarkers and Prevention, 21(12), 2209-2219. https://doi.org/10.1158/1055-9965.EPI-12-0961

    Prospective study on physical activity and risk of in situ breast cancer. / Steindorf, Karen; Ritte, Rebecca; Tjonneland, Anne; Johnsen, Nina Føns; Overvad, Kim; Østergaard, Jane Nautrup; Clavel-Chapelon, Françoise; Fournier, Agnès; Dossus, Laure; Lukanova, Annekatrin; Chang-Claude, Jenny; Boeing, Heiner; Wientzek, Angelika; Trichopoulou, Antonia; Karapetyan, Tina; Trichopoulos, Dimitrios; Masala, Giovanna; Krogh, Vittorio; Mattiello, Amalia; Tumino, Rosario; Polidoro, Silvia; Quirós, José Ramón; Travier, Noémie; Sánchez, María José; Navarro, Carmen; Ardanaz, Eva; Amiano, Pilar; Bueno-de-Mesquita, H. Bas; Van Duijnhoven, Fränzel J B; Monninkhof, Evelyn; May, Anne M.; Khaw, Kay Tee; Wareham, Nick; Key, Tim J.; Travis, Ruth C.; Borch, Kristin Benjaminsen; Fedirko, Veronika; Rinaldi, Sabina; Romieu, Isabelle; Wark, Petra A.; Norat, Teresa; Riboli, Elio; Kaaks, Rudolf.

    In: Cancer Epidemiology Biomarkers and Prevention, Vol. 21, No. 12, 12.2012, p. 2209-2219.

    Research output: Contribution to journalArticle

    Steindorf, K, Ritte, R, Tjonneland, A, Johnsen, NF, Overvad, K, Østergaard, JN, Clavel-Chapelon, F, Fournier, A, Dossus, L, Lukanova, A, Chang-Claude, J, Boeing, H, Wientzek, A, Trichopoulou, A, Karapetyan, T, Trichopoulos, D, Masala, G, Krogh, V, Mattiello, A, Tumino, R, Polidoro, S, Quirós, JR, Travier, N, Sánchez, MJ, Navarro, C, Ardanaz, E, Amiano, P, Bueno-de-Mesquita, HB, Van Duijnhoven, FJB, Monninkhof, E, May, AM, Khaw, KT, Wareham, N, Key, TJ, Travis, RC, Borch, KB, Fedirko, V, Rinaldi, S, Romieu, I, Wark, PA, Norat, T, Riboli, E & Kaaks, R 2012, 'Prospective study on physical activity and risk of in situ breast cancer' Cancer Epidemiology Biomarkers and Prevention, vol. 21, no. 12, pp. 2209-2219. https://doi.org/10.1158/1055-9965.EPI-12-0961
    Steindorf K, Ritte R, Tjonneland A, Johnsen NF, Overvad K, Østergaard JN et al. Prospective study on physical activity and risk of in situ breast cancer. Cancer Epidemiology Biomarkers and Prevention. 2012 Dec;21(12):2209-2219. https://doi.org/10.1158/1055-9965.EPI-12-0961
    Steindorf, Karen ; Ritte, Rebecca ; Tjonneland, Anne ; Johnsen, Nina Føns ; Overvad, Kim ; Østergaard, Jane Nautrup ; Clavel-Chapelon, Françoise ; Fournier, Agnès ; Dossus, Laure ; Lukanova, Annekatrin ; Chang-Claude, Jenny ; Boeing, Heiner ; Wientzek, Angelika ; Trichopoulou, Antonia ; Karapetyan, Tina ; Trichopoulos, Dimitrios ; Masala, Giovanna ; Krogh, Vittorio ; Mattiello, Amalia ; Tumino, Rosario ; Polidoro, Silvia ; Quirós, José Ramón ; Travier, Noémie ; Sánchez, María José ; Navarro, Carmen ; Ardanaz, Eva ; Amiano, Pilar ; Bueno-de-Mesquita, H. Bas ; Van Duijnhoven, Fränzel J B ; Monninkhof, Evelyn ; May, Anne M. ; Khaw, Kay Tee ; Wareham, Nick ; Key, Tim J. ; Travis, Ruth C. ; Borch, Kristin Benjaminsen ; Fedirko, Veronika ; Rinaldi, Sabina ; Romieu, Isabelle ; Wark, Petra A. ; Norat, Teresa ; Riboli, Elio ; Kaaks, Rudolf. / Prospective study on physical activity and risk of in situ breast cancer. In: Cancer Epidemiology Biomarkers and Prevention. 2012 ; Vol. 21, No. 12. pp. 2209-2219.
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    title = "Prospective study on physical activity and risk of in situ breast cancer",
    abstract = "Background: Physical activity has been identified as protective factor for invasive breast cancer risk, whereas comparable studies on in situ carcinoma are rare. Methods: The study included data from 283,827 women of the multinational European Prospective Investigation into C7ancer and Nutrition (EPIC)-cohort study. Detailed information on different types of physical activity conducted during the prior year, such as occupational, recreational, and household activity, as well as on important cofactors, was assessed at baseline. Adjusted HRs for in situ breast cancer were estimated by Cox proportional hazards models. Results: During a median follow-up period of 11.7 years, 1,059 incidents of breast carcinoma in situ were identified. In crude and adjusted multivariable models, no associations were found for occupational, household, and recreational physical activity. Furthermore, total physical activity was not associated with risk of in situ breast cancer. Comparing moderately inactive, moderately active, and active participants with inactive study participants resulted in adjusted HRs of 0.99 [95{\%} confidence interval (CI), 0.83-1.19], 0.99 (95{\%} CI, 0.82-1.20), and 1.07 (95{\%} CI, 0.81-1.40), respectively (P value of trend test: 0.788). No inverse associations were found in any substrata defined by age at diagnosis or body mass index (BMI) status. Conclusions: In this large prospective study, we did not find any evidence of an association between physical activity and in situ breast cancer risk. If not by chance, the contrast between our results for carcinoma in situ and the recognized inverse association for invasive breast cancer suggests that physical activity may have stronger effects on proliferation and late stage carcinogenesis.",
    author = "Karen Steindorf and Rebecca Ritte and Anne Tjonneland and Johnsen, {Nina F{\o}ns} and Kim Overvad and {\O}stergaard, {Jane Nautrup} and Fran{\cc}oise Clavel-Chapelon and Agn{\`e}s Fournier and Laure Dossus and Annekatrin Lukanova and Jenny Chang-Claude and Heiner Boeing and Angelika Wientzek and Antonia Trichopoulou and Tina Karapetyan and Dimitrios Trichopoulos and Giovanna Masala and Vittorio Krogh and Amalia Mattiello and Rosario Tumino and Silvia Polidoro and Quir{\'o}s, {Jos{\'e} Ram{\'o}n} and No{\'e}mie Travier and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Carmen Navarro and Eva Ardanaz and Pilar Amiano and Bueno-de-Mesquita, {H. Bas} and {Van Duijnhoven}, {Fr{\"a}nzel J B} and Evelyn Monninkhof and May, {Anne M.} and Khaw, {Kay Tee} and Nick Wareham and Key, {Tim J.} and Travis, {Ruth C.} and Borch, {Kristin Benjaminsen} and Veronika Fedirko and Sabina Rinaldi and Isabelle Romieu and Wark, {Petra A.} and Teresa Norat and Elio Riboli and Rudolf Kaaks",
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    TY - JOUR

    T1 - Prospective study on physical activity and risk of in situ breast cancer

    AU - Steindorf, Karen

    AU - Ritte, Rebecca

    AU - Tjonneland, Anne

    AU - Johnsen, Nina Føns

    AU - Overvad, Kim

    AU - Østergaard, Jane Nautrup

    AU - Clavel-Chapelon, Françoise

    AU - Fournier, Agnès

    AU - Dossus, Laure

    AU - Lukanova, Annekatrin

    AU - Chang-Claude, Jenny

    AU - Boeing, Heiner

    AU - Wientzek, Angelika

    AU - Trichopoulou, Antonia

    AU - Karapetyan, Tina

    AU - Trichopoulos, Dimitrios

    AU - Masala, Giovanna

    AU - Krogh, Vittorio

    AU - Mattiello, Amalia

    AU - Tumino, Rosario

    AU - Polidoro, Silvia

    AU - Quirós, José Ramón

    AU - Travier, Noémie

    AU - Sánchez, María José

    AU - Navarro, Carmen

    AU - Ardanaz, Eva

    AU - Amiano, Pilar

    AU - Bueno-de-Mesquita, H. Bas

    AU - Van Duijnhoven, Fränzel J B

    AU - Monninkhof, Evelyn

    AU - May, Anne M.

    AU - Khaw, Kay Tee

    AU - Wareham, Nick

    AU - Key, Tim J.

    AU - Travis, Ruth C.

    AU - Borch, Kristin Benjaminsen

    AU - Fedirko, Veronika

    AU - Rinaldi, Sabina

    AU - Romieu, Isabelle

    AU - Wark, Petra A.

    AU - Norat, Teresa

    AU - Riboli, Elio

    AU - Kaaks, Rudolf

    PY - 2012/12

    Y1 - 2012/12

    N2 - Background: Physical activity has been identified as protective factor for invasive breast cancer risk, whereas comparable studies on in situ carcinoma are rare. Methods: The study included data from 283,827 women of the multinational European Prospective Investigation into C7ancer and Nutrition (EPIC)-cohort study. Detailed information on different types of physical activity conducted during the prior year, such as occupational, recreational, and household activity, as well as on important cofactors, was assessed at baseline. Adjusted HRs for in situ breast cancer were estimated by Cox proportional hazards models. Results: During a median follow-up period of 11.7 years, 1,059 incidents of breast carcinoma in situ were identified. In crude and adjusted multivariable models, no associations were found for occupational, household, and recreational physical activity. Furthermore, total physical activity was not associated with risk of in situ breast cancer. Comparing moderately inactive, moderately active, and active participants with inactive study participants resulted in adjusted HRs of 0.99 [95% confidence interval (CI), 0.83-1.19], 0.99 (95% CI, 0.82-1.20), and 1.07 (95% CI, 0.81-1.40), respectively (P value of trend test: 0.788). No inverse associations were found in any substrata defined by age at diagnosis or body mass index (BMI) status. Conclusions: In this large prospective study, we did not find any evidence of an association between physical activity and in situ breast cancer risk. If not by chance, the contrast between our results for carcinoma in situ and the recognized inverse association for invasive breast cancer suggests that physical activity may have stronger effects on proliferation and late stage carcinogenesis.

    AB - Background: Physical activity has been identified as protective factor for invasive breast cancer risk, whereas comparable studies on in situ carcinoma are rare. Methods: The study included data from 283,827 women of the multinational European Prospective Investigation into C7ancer and Nutrition (EPIC)-cohort study. Detailed information on different types of physical activity conducted during the prior year, such as occupational, recreational, and household activity, as well as on important cofactors, was assessed at baseline. Adjusted HRs for in situ breast cancer were estimated by Cox proportional hazards models. Results: During a median follow-up period of 11.7 years, 1,059 incidents of breast carcinoma in situ were identified. In crude and adjusted multivariable models, no associations were found for occupational, household, and recreational physical activity. Furthermore, total physical activity was not associated with risk of in situ breast cancer. Comparing moderately inactive, moderately active, and active participants with inactive study participants resulted in adjusted HRs of 0.99 [95% confidence interval (CI), 0.83-1.19], 0.99 (95% CI, 0.82-1.20), and 1.07 (95% CI, 0.81-1.40), respectively (P value of trend test: 0.788). No inverse associations were found in any substrata defined by age at diagnosis or body mass index (BMI) status. Conclusions: In this large prospective study, we did not find any evidence of an association between physical activity and in situ breast cancer risk. If not by chance, the contrast between our results for carcinoma in situ and the recognized inverse association for invasive breast cancer suggests that physical activity may have stronger effects on proliferation and late stage carcinogenesis.

    U2 - 10.1158/1055-9965.EPI-12-0961

    DO - 10.1158/1055-9965.EPI-12-0961

    M3 - Article

    VL - 21

    SP - 2209

    EP - 2219

    JO - Cancer Epidemiology Biomarkers and Prevention

    JF - Cancer Epidemiology Biomarkers and Prevention

    SN - 1055-9965

    IS - 12

    ER -