Prolonged survival of skin grafts following treatment with an antibody to a putative cell triggering molecule, QCA‐1

Richard Aspinall, Jaap Kampinga, Johan Van Den Bogaerde

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The QCA‐1 molecule (quiescent cell antigen‐1) appears to be involved in the differentiation events undergone by T cell following occupancy of the antigen receptor. Here we show that modulation of the QCA‐1 antigen from the surface of the cell normally follows activation, and that treatment of animals with the antibodies against the QCA‐1 molecule inhibits the normal response to an allograft without appearing to alter the number of peripheral T cells or the expression by these cells of the α/β T cell antigen receptor.

Original languageEnglish
Pages (from-to)3053-3056
Number of pages4
JournalEuropean Journal of Immunology
Volume21
Issue number12
DOIs
Publication statusPublished - Dec 1991
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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