Prolonged survival of skin grafts following treatment with an antibody to a putative cell triggering molecule, QCA‐1

The QCA‐1 molecule (quiescent cell antigen‐1) appears to be involved in the differentiation events undergone by T cell following occupancy of the antigen receptor. Here we show that modulation of the QCA‐1 antigen from the surface of the cell normally follows activation, and that treatment of animals with the antibodies against the QCA‐1 molecule inhibits the normal response to an allograft without appearing to alter the number of peripheral T cells or the expression by these cells of the α/β T cell antigen receptor.