Prevalence and predictors of obstructive sleep apnea in young children with Down syndrome

C. M. Hill; H. Evans; H. Elphick; M. Farquhar; R. M. Pickering; R. Kingshott; J. Martin; J. Reynolds; Anna Joyce; C. Rush; J. Gavlak; P. Gringras

doi:10.1016/j.sleep.2016.10.001

Prevalence and predictors of obstructive sleep apnea in young children with Down syndrome

C. M. Hill, H. Evans, H. Elphick, M. Farquhar, R. M. Pickering, R. Kingshott, J. Martin, J. Reynolds, Anna Joyce, C. Rush, J. Gavlak, P. Gringras

University of Southampton

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Abstract

Background Children with Down syndrome (DS) are vulnerable to obstructive sleep apnea (OSA) due to their unique craniofacial anatomy and hypotonia. Understanding the predictors of OSA in DS may inform targeted screening. Methods 202 children with DS aged six months to sixth birthday (110 boys) were recruited from three UK children’s hospitals. Clinical assessment included height, weight and tonsillar size. Parents set up cardiorespiratory polygraphy at home or chose laboratory studies. Studies with less than four hours of interpretable data were repeated where possible. AASM 2012 scoring criteria were used to derive an obstructive apnea/hypopnea index (OAHI). Predictors of moderate to severe OSA were examined. Results 188/202 (93%) participants were successfully studied. Of these, 169 studies were completed at home and 19 in a sleep laboratory. Moderate –severe OSA, defined by an OAHI>5/hour, was found in 14%; and mild-moderate OSA (OAHI > 1

Original language	English
Pages (from-to)	99-106
Number of pages	8
Journal	Sleep Medicine
Volume	27-28
Early online date	22 Oct 2016
DOIs	https://doi.org/10.1016/j.sleep.2016.10.001
Publication status	Published - Nov 2016

Keywords

Down Syndrome
Obstructive Sleep Apnea
Sleep Disordered Breathing
Cardiorespiratory polygraphy

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10.1016/j.sleep.2016.10.001

Hill_et_al_Prevalence_predictors_Sleep_medicineAccepted author manuscript, 1.67 MBLicence: CC BY-NC-ND

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title = "Prevalence and predictors of obstructive sleep apnea in young children with Down syndrome",

abstract = "Background Children with Down syndrome (DS) are vulnerable to obstructive sleep apnea (OSA) due to their unique craniofacial anatomy and hypotonia. Understanding the predictors of OSA in DS may inform targeted screening. Methods 202 children with DS aged six months to sixth birthday (110 boys) were recruited from three UK children{\textquoteright}s hospitals. Clinical assessment included height, weight and tonsillar size. Parents set up cardiorespiratory polygraphy at home or chose laboratory studies. Studies with less than four hours of interpretable data were repeated where possible. AASM 2012 scoring criteria were used to derive an obstructive apnea/hypopnea index (OAHI). Predictors of moderate to severe OSA were examined. Results 188/202 (93%) participants were successfully studied. Of these, 169 studies were completed at home and 19 in a sleep laboratory. Moderate –severe OSA, defined by an OAHI>5/hour, was found in 14%; and mild-moderate OSA (OAHI > 1",

keywords = "Down Syndrome, Obstructive Sleep Apnea, Sleep Disordered Breathing, Cardiorespiratory polygraphy",

author = "Hill, {C. M.} and H. Evans and H. Elphick and M. Farquhar and Pickering, {R. M.} and R. Kingshott and J. Martin and J. Reynolds and Anna Joyce and C. Rush and J. Gavlak and P. Gringras",

year = "2016",

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doi = "10.1016/j.sleep.2016.10.001",

language = "English",

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T1 - Prevalence and predictors of obstructive sleep apnea in young children with Down syndrome

AU - Hill, C. M.

AU - Evans, H.

AU - Elphick, H.

AU - Farquhar, M.

AU - Pickering, R. M.

AU - Kingshott, R.

AU - Martin, J.

AU - Reynolds, J.

AU - Joyce, Anna

AU - Rush, C.

AU - Gavlak, J.

AU - Gringras, P.

PY - 2016/11

Y1 - 2016/11

N2 - Background Children with Down syndrome (DS) are vulnerable to obstructive sleep apnea (OSA) due to their unique craniofacial anatomy and hypotonia. Understanding the predictors of OSA in DS may inform targeted screening. Methods 202 children with DS aged six months to sixth birthday (110 boys) were recruited from three UK children’s hospitals. Clinical assessment included height, weight and tonsillar size. Parents set up cardiorespiratory polygraphy at home or chose laboratory studies. Studies with less than four hours of interpretable data were repeated where possible. AASM 2012 scoring criteria were used to derive an obstructive apnea/hypopnea index (OAHI). Predictors of moderate to severe OSA were examined. Results 188/202 (93%) participants were successfully studied. Of these, 169 studies were completed at home and 19 in a sleep laboratory. Moderate –severe OSA, defined by an OAHI>5/hour, was found in 14%; and mild-moderate OSA (OAHI > 1

AB - Background Children with Down syndrome (DS) are vulnerable to obstructive sleep apnea (OSA) due to their unique craniofacial anatomy and hypotonia. Understanding the predictors of OSA in DS may inform targeted screening. Methods 202 children with DS aged six months to sixth birthday (110 boys) were recruited from three UK children’s hospitals. Clinical assessment included height, weight and tonsillar size. Parents set up cardiorespiratory polygraphy at home or chose laboratory studies. Studies with less than four hours of interpretable data were repeated where possible. AASM 2012 scoring criteria were used to derive an obstructive apnea/hypopnea index (OAHI). Predictors of moderate to severe OSA were examined. Results 188/202 (93%) participants were successfully studied. Of these, 169 studies were completed at home and 19 in a sleep laboratory. Moderate –severe OSA, defined by an OAHI>5/hour, was found in 14%; and mild-moderate OSA (OAHI > 1

KW - Down Syndrome

KW - Obstructive Sleep Apnea

KW - Sleep Disordered Breathing

KW - Cardiorespiratory polygraphy

U2 - 10.1016/j.sleep.2016.10.001

DO - 10.1016/j.sleep.2016.10.001

M3 - Article

SN - 1389-9457

SN - 1878-5506

VL - 27-28

SP - 99

EP - 106

JO - Sleep Medicine

JF - Sleep Medicine

ER -

Prevalence and predictors of obstructive sleep apnea in young children with Down syndrome

Abstract

Keywords

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