Prevalence and predictors of obstructive sleep apnea in young children with Down syndrome

C. M. Hill, H. Evans, H. Elphick, M. Farquhar, R. M. Pickering, R. Kingshott, J. Martin, J. Reynolds, Anna Joyce, C. Rush, J. Gavlak, P. Gringras

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    Background Children with Down syndrome (DS) are vulnerable to obstructive sleep apnea (OSA) due to their unique craniofacial anatomy and hypotonia. Understanding the predictors of OSA in DS may inform targeted screening. Methods 202 children with DS aged six months to sixth birthday (110 boys) were recruited from three UK children’s hospitals. Clinical assessment included height, weight and tonsillar size. Parents set up cardiorespiratory polygraphy at home or chose laboratory studies. Studies with less than four hours of interpretable data were repeated where possible. AASM 2012 scoring criteria were used to derive an obstructive apnea/hypopnea index (OAHI). Predictors of moderate to severe OSA were examined. Results 188/202 (93%) participants were successfully studied. Of these, 169 studies were completed at home and 19 in a sleep laboratory. Moderate –severe OSA, defined by an OAHI>5/hour, was found in 14%; and mild-moderate OSA (OAHI > 1
    Original languageEnglish
    Pages (from-to)99-106
    Number of pages8
    JournalSleep Medicine
    Early online date22 Oct 2016
    Publication statusPublished - Nov 2016


    • Down Syndrome
    • Obstructive Sleep Apnea
    • Sleep Disordered Breathing
    • Cardiorespiratory polygraphy


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