Preoperative antiviral therapy and microvascular invasion in hepatitis B virus-related hepatocellular carcinoma: A Meta-Analysis

Zhenchang Wang, Yunjie Duan, Jinmei Zhang, Yanhang Lv, Shanshan Wu, Mingrong Cheng, Akshaya Srikanth Bhagavathula, Wafa Ali Aldhaleei, Cain Clark, Zongwei Huo

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    3 Citations (Scopus)
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    Microvascular invasion (MVI) is an important predictor of metastatic tumour recurrence and is associated with adverse outcomes and poor prognosis in Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients. The association between varying regimens of anti-viral drugs with the incidence of MVI in HBV-related HCC has been demonstrated, however, no meta-analysis of the available data has been conducted. Therefore, the current study sought to evaluate the association of preoperative antiviral therapy with incidence of microvascular invasion in HCC hepatitis virus patients. A systematic search of the literature was performed in MEDLINE/PubMed, Web of Science (WoS), and Scopus, up to January 2020. A random-effects model was used to estimate pooled odds ratios (ORs). Overall, six studies, with 4988 patients, met our inclusion criteria. The pooled OR of MVI in the patients who had preoperative antiviral therapy versus the patients who did not have antiviral therapy was; OR: 0.60, 95% Confidence Interval (CI): 0.49–0.73; I 2 = 25%. In this study, a significant reduction in the OR of MVI was evident in patients who had anti-viral therapy.

    Original languageEnglish
    Article number173382
    JournalEuropean Journal of Pharmacology
    Early online date18 Jul 2020
    Publication statusPublished - 15 Sept 2020

    Bibliographical note

    NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmacology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Journal of Pharmacology, 883, (2020)
    DOI: 10.1016/j.ejphar.2020.173382

    © 2020, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International


    • Anti-viral therapy
    • Hepatitis B
    • Hepatocellular carcinoma
    • Microvascular invasion

    ASJC Scopus subject areas

    • Pharmacology


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