Preoperative antiviral therapy and microvascular invasion in hepatitis B virus-related hepatocellular carcinoma: A Meta-Analysis

Zhenchang Wang, Yunjie Duan, Jinmei Zhang, Yanhang Lv, Shanshan Wu, Mingrong Cheng, Akshaya Srikanth Bhagavathula, Wafa Ali Aldhaleei, Cain Clark, Zongwei Huo

Research output: Contribution to journalReview article

Abstract

Microvascular invasion (MVI) is an important predictor of metastatic tumour recurrence and is associated with adverse outcomes and poor prognosis in Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients. The association between varying regimens of anti-viral drugs with the incidence of MVI in HBV-related HCC has been demonstrated, however, no meta-analysis of the available data has been conducted. Therefore, the current study sought to evaluate the association of preoperative antiviral therapy with incidence of microvascular invasion in HCC hepatitis virus patients. A systematic search of the literature was performed in MEDLINE/PubMed, Web of Science (WoS), and Scopus, up to January 2020. A random-effects model was used to estimate pooled odds ratios (ORs). Overall, six studies, with 4988 patients, met our inclusion criteria. The pooled OR of MVI in the patients who had preoperative antiviral therapy versus the patients who did not have antiviral therapy was; OR: 0.60, 95% Confidence Interval (CI): 0.49–0.73; I 2 = 25%. In this study, a significant reduction in the OR of MVI was evident in patients who had anti-viral therapy.

Original languageEnglish
Article number173382
JournalEuropean Journal of Pharmacology
Volume883
Early online date18 Jul 2020
DOIs
Publication statusPublished - 15 Sep 2020

Keywords

  • Anti-viral therapy
  • Hepatitis B
  • Hepatocellular carcinoma
  • Microvascular invasion

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Preoperative antiviral therapy and microvascular invasion in hepatitis B virus-related hepatocellular carcinoma: A Meta-Analysis'. Together they form a unique fingerprint.

  • Cite this