Prediction of the toxicity of mixtures of shale oil components

M. St J. Warne; D. W. Connell; D. W. Hawker; G. Schüürmann

doi:10.1016/0147-6513(89)90072-9

Prediction of the toxicity of mixtures of shale oil components

M. St J. Warne, D. W. Connell, D. W. Hawker, G. Schüürmann

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The toxicities of selected oil shale components and of mixtures of these components to a mixed marine bacterial culture have been determined. The toxicities of mixtures whose components were members of the same homologous series were found to be additive. In all other cases, even when the compounds were as closely related as structural isomers, synergism was observed. Simple and multiple linear regression equations utilizing measures of toxicity and molecular descriptors were used successfully to predict the enhancement of toxicity due to interaction of components in mixtures regardless of the mode of interaction.

Original language	English
Pages (from-to)	121-128
Number of pages	8
Journal	Ecotoxicology and Environmental Safety
Volume	18
Issue number	2
DOIs	https://doi.org/10.1016/0147-6513(89)90072-9
Publication status	Published - Oct 1989
Externally published	Yes

ASJC Scopus subject areas

Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0147-6513(89)90072-9

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abstract = "The toxicities of selected oil shale components and of mixtures of these components to a mixed marine bacterial culture have been determined. The toxicities of mixtures whose components were members of the same homologous series were found to be additive. In all other cases, even when the compounds were as closely related as structural isomers, synergism was observed. Simple and multiple linear regression equations utilizing measures of toxicity and molecular descriptors were used successfully to predict the enhancement of toxicity due to interaction of components in mixtures regardless of the mode of interaction.",

author = "Warne, {M. St J.} and Connell, {D. W.} and Hawker, {D. W.} and G. Sch{\"u}{\"u}rmann",

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AU - Hawker, D. W.

AU - Schüürmann, G.

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N2 - The toxicities of selected oil shale components and of mixtures of these components to a mixed marine bacterial culture have been determined. The toxicities of mixtures whose components were members of the same homologous series were found to be additive. In all other cases, even when the compounds were as closely related as structural isomers, synergism was observed. Simple and multiple linear regression equations utilizing measures of toxicity and molecular descriptors were used successfully to predict the enhancement of toxicity due to interaction of components in mixtures regardless of the mode of interaction.

AB - The toxicities of selected oil shale components and of mixtures of these components to a mixed marine bacterial culture have been determined. The toxicities of mixtures whose components were members of the same homologous series were found to be additive. In all other cases, even when the compounds were as closely related as structural isomers, synergism was observed. Simple and multiple linear regression equations utilizing measures of toxicity and molecular descriptors were used successfully to predict the enhancement of toxicity due to interaction of components in mixtures regardless of the mode of interaction.

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ER -

Prediction of the toxicity of mixtures of shale oil components

Abstract

ASJC Scopus subject areas

UN SDGs

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