The toxicities of selected oil shale components and of mixtures of these components to a mixed marine bacterial culture have been determined. The toxicities of mixtures whose components were members of the same homologous series were found to be additive. In all other cases, even when the compounds were as closely related as structural isomers, synergism was observed. Simple and multiple linear regression equations utilizing measures of toxicity and molecular descriptors were used successfully to predict the enhancement of toxicity due to interaction of components in mixtures regardless of the mode of interaction.
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis