TY - JOUR
T1 - Prediagnostic circulating parathyroid hormone concentration and colorectal cancer in the European prospective investigation into cancer and nutrition cohort
AU - Fedirko, Veronika
AU - Riboli, Elio
AU - Bas Bueno-de-Mesquita, H.
AU - Rinaldi, Sabina
AU - Pischon, Tobias
AU - Norat, Teresa
AU - Jansen, Eugène H J M
AU - Van Duijnhoven, Fränzel J B
AU - Tjønneland, Anne
AU - Overvad, Kim
AU - Boutron-Ruault, Marie Christine
AU - Clavel-Chapelon, Françoise
AU - Engel, Pierre
AU - Kaaks, Rudolf
AU - Teucher, Birgit
AU - Boeing, Heiner
AU - Buijsse, Brian
AU - Trichopoulou, Antonia
AU - Trichopoulos, Dimitrios
AU - Lagiou, Pagona
AU - Sieri, Sabina
AU - Vineis, Paolo
AU - Panico, Salvatore
AU - Palli, Domenico
AU - Tumino, Rosario
AU - Van Gils, Carla H.
AU - Peeters, Petra H M
AU - Chirlaque, Maria Dolores
AU - Gurrea, Aurelio Barricarte
AU - Rodríguez, Laudina
AU - Molina-Montes, Esther
AU - Dorronsoro, Miren
AU - Bonet, Catalina
AU - Palmqvist, Richard
AU - Hallmans, Göran
AU - Key, Timothy J.
AU - Tsilidis, Konstantinos K.
AU - Khaw, Kay Tee
AU - Romieu, Isabelle
AU - Straif, Kurt
AU - Wark, Petra A.
AU - Romaguera, Dora
AU - Jenab, Mazda
PY - 2011/5
Y1 - 2011/5
N2 - Background: Parathyroid hormone (PTH) has been proposed to play a promoting role in carcinogenesis. However, no epidemiologic studies have yet directly investigated its role in colorectal cancer (CRC). Methods: A case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort was conducted with 1,214 incident, sporadic CRC cases matched to 1,214 controls. Circulating prediagnostic PTH and 25-hydroxy vitamin D [25(OH)D] concentrations were measured by enzyme-linked immunosorbent assays. Detailed dietary and lifestyle questionnaire data were collected at baseline. Multivariable conditional logistic regression was used to estimate the incidence rate ratio (RR) with 95% confidence intervals (95% CI) for the association between circulating PTH and CRC risk. Results: In multivariate analyses [including adjustment for 25(OH)D concentration] with a priori defined cutoff points, high levels of serum PTH (≥65 ng/L) compared with medium PTH levels of 30-65 ng/L were associated with increasedCRCrisk (RR = 1.41,95%CI: 1.03-1.93). In analyses by sex, theCRCrisk was 1.77 (95% CI: 1.14-2.75) and 1.15 (95% CI: 0.73-1.84) in men and women, respectively (Pheterogeneity = 0.01). In subgroup analyses by anatomical subsite, the risk for colon cancer was RR = 1.56, 95% CI: 1.03-2.34, and for rectal cancer RR = 1.20, 95% CI: 0.72-2.01 (Pheterogeneity = 0.21). Effect modification by various risk factors was examined. Conclusions: The results of this study suggest that high serum PTH levels may be associated with incident, sporadic CRC in Western European populations, and in particular among men. Impact: To our knowledge, this is the first study on PTH and CRC. The role of PTH in carcinogenesis needs to be further investigated.
AB - Background: Parathyroid hormone (PTH) has been proposed to play a promoting role in carcinogenesis. However, no epidemiologic studies have yet directly investigated its role in colorectal cancer (CRC). Methods: A case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort was conducted with 1,214 incident, sporadic CRC cases matched to 1,214 controls. Circulating prediagnostic PTH and 25-hydroxy vitamin D [25(OH)D] concentrations were measured by enzyme-linked immunosorbent assays. Detailed dietary and lifestyle questionnaire data were collected at baseline. Multivariable conditional logistic regression was used to estimate the incidence rate ratio (RR) with 95% confidence intervals (95% CI) for the association between circulating PTH and CRC risk. Results: In multivariate analyses [including adjustment for 25(OH)D concentration] with a priori defined cutoff points, high levels of serum PTH (≥65 ng/L) compared with medium PTH levels of 30-65 ng/L were associated with increasedCRCrisk (RR = 1.41,95%CI: 1.03-1.93). In analyses by sex, theCRCrisk was 1.77 (95% CI: 1.14-2.75) and 1.15 (95% CI: 0.73-1.84) in men and women, respectively (Pheterogeneity = 0.01). In subgroup analyses by anatomical subsite, the risk for colon cancer was RR = 1.56, 95% CI: 1.03-2.34, and for rectal cancer RR = 1.20, 95% CI: 0.72-2.01 (Pheterogeneity = 0.21). Effect modification by various risk factors was examined. Conclusions: The results of this study suggest that high serum PTH levels may be associated with incident, sporadic CRC in Western European populations, and in particular among men. Impact: To our knowledge, this is the first study on PTH and CRC. The role of PTH in carcinogenesis needs to be further investigated.
U2 - 10.1158/1055-9965.EPI-10-1212
DO - 10.1158/1055-9965.EPI-10-1212
M3 - Article
C2 - 21378267
AN - SCOPUS:79955784215
SN - 1055-9965
VL - 20
SP - 767
EP - 778
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 5
ER -