Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis: The EPIC cohort

Valentina Gallo, Petra A. Wark, Mazda Jenab, Neil Pearce, Carol Brayne, Roel Vermeulen, Peter M. Andersen, Goran Hallmans, Andreas Kyrozis, Nicola Vanacore, Mariam Vahdaninia, Verena Grote, Rudolf Kaaks, Amalia Mattiello, H. Bas Bueno-De-mesquita, Petra H. Peeters, Ruth C. Travis, Jesper Petersson, Oskar Hansson, Larraitz Arriola & 25 others Juan Manuel Jimenez Martin, Anne Tjønneland, Jytte Halkjær, Claudia Agnoli, Carlotta Sacerdote, Catalina Bonet, Antonia Trichopoulou, Diana Gavrila, Kim Overvad, Elisabete Weiderpass, Domenico Palli, J. Ramón Quirós, Rosario Tumino, Kay Tee Khaw, Nicholas Wareham, Aurelio Barricante-Gurrea, Veronika Fedirko, Pietro Ferrari, Françoise Clavel-Chapelon, Marie Christine Boutron Ruault, Heiner Boeing, Matthaeus Vigl, Lefkos Middleton, Elio Riboli, Paolo Vineis

    Research output: Contribution to journalArticle

    63 Citations (Scopus)

    Abstract

    Objectives: The aim of this study was to investigate for the first time the association between body fat and risk of amyotrophic lateral sclerosis (ALS) with an appropriate prospective study design. Methods: The EPIC (European Prospective Investigation into Cancer and Nutrition) study included 518,108 individuals recruited from the general population across 10 Western European countries. At recruitment, information on lifestyle was collected and anthropometric characteristics were measured. Cox hazard models were fitted to investigate the associations between anthropometric measures and ALS mortality. Results: Two hundred twenty-two ALS deaths (79 men and 143 women) occurred during the followup period (mean follow-up 5 13 years). There was a statistically significant interaction between categories of body mass index and sex regarding ALS risk (p 5 0.009): in men, a significant linear decrease of risk per unit of body mass index was observed (hazard ratio 5 0.93, 95% confidence interval 0.86-0.99 per kg/m2); among women, the risk was more than 3-fold increased for underweight compared with normal-weight women. Among women, a significant risk reduction increasing the waist/hip ratio was also evident: women in the top quartile had less than half the risk of ALS compared with those in the bottom quartile (hazard ratio 5 0.48, 95% confidence interval 0.25-0.93) with a borderline significant p value for trend across quartiles (p 5 0.056). Conclusion: Increased prediagnostic body fat is associated with a decreased risk of ALS mortality.

    Original languageEnglish
    Pages (from-to)829-838
    Number of pages10
    JournalNeurology
    Volume80
    Issue number9
    Early online date6 Feb 2013
    DOIs
    Publication statusPublished - 26 Feb 2013

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    Amyotrophic Lateral Sclerosis
    Adipose Tissue
    Proportional Hazards Models
    Body Mass Index
    Confidence Intervals
    Waist-Hip Ratio
    Mortality
    Thinness
    Risk Reduction Behavior
    Life Style
    Prospective Studies
    Weights and Measures
    Population
    Neoplasms

    ASJC Scopus subject areas

    • Clinical Neurology

    Cite this

    Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis : The EPIC cohort. / Gallo, Valentina; Wark, Petra A.; Jenab, Mazda; Pearce, Neil; Brayne, Carol; Vermeulen, Roel; Andersen, Peter M.; Hallmans, Goran; Kyrozis, Andreas; Vanacore, Nicola; Vahdaninia, Mariam; Grote, Verena; Kaaks, Rudolf; Mattiello, Amalia; Bas Bueno-De-mesquita, H.; Peeters, Petra H.; Travis, Ruth C.; Petersson, Jesper; Hansson, Oskar; Arriola, Larraitz; Martin, Juan Manuel Jimenez; Tjønneland, Anne; Halkjær, Jytte; Agnoli, Claudia; Sacerdote, Carlotta; Bonet, Catalina; Trichopoulou, Antonia; Gavrila, Diana; Overvad, Kim; Weiderpass, Elisabete; Palli, Domenico; Quirós, J. Ramón; Tumino, Rosario; Khaw, Kay Tee; Wareham, Nicholas; Barricante-Gurrea, Aurelio; Fedirko, Veronika; Ferrari, Pietro; Clavel-Chapelon, Françoise; Ruault, Marie Christine Boutron; Boeing, Heiner; Vigl, Matthaeus; Middleton, Lefkos; Riboli, Elio; Vineis, Paolo.

    In: Neurology, Vol. 80, No. 9, 26.02.2013, p. 829-838.

    Research output: Contribution to journalArticle

    Gallo, V, Wark, PA, Jenab, M, Pearce, N, Brayne, C, Vermeulen, R, Andersen, PM, Hallmans, G, Kyrozis, A, Vanacore, N, Vahdaninia, M, Grote, V, Kaaks, R, Mattiello, A, Bas Bueno-De-mesquita, H, Peeters, PH, Travis, RC, Petersson, J, Hansson, O, Arriola, L, Martin, JMJ, Tjønneland, A, Halkjær, J, Agnoli, C, Sacerdote, C, Bonet, C, Trichopoulou, A, Gavrila, D, Overvad, K, Weiderpass, E, Palli, D, Quirós, JR, Tumino, R, Khaw, KT, Wareham, N, Barricante-Gurrea, A, Fedirko, V, Ferrari, P, Clavel-Chapelon, F, Ruault, MCB, Boeing, H, Vigl, M, Middleton, L, Riboli, E & Vineis, P 2013, 'Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis: The EPIC cohort' Neurology, vol. 80, no. 9, pp. 829-838. https://doi.org/10.1212/WNL.0b013e3182840689
    Gallo, Valentina ; Wark, Petra A. ; Jenab, Mazda ; Pearce, Neil ; Brayne, Carol ; Vermeulen, Roel ; Andersen, Peter M. ; Hallmans, Goran ; Kyrozis, Andreas ; Vanacore, Nicola ; Vahdaninia, Mariam ; Grote, Verena ; Kaaks, Rudolf ; Mattiello, Amalia ; Bas Bueno-De-mesquita, H. ; Peeters, Petra H. ; Travis, Ruth C. ; Petersson, Jesper ; Hansson, Oskar ; Arriola, Larraitz ; Martin, Juan Manuel Jimenez ; Tjønneland, Anne ; Halkjær, Jytte ; Agnoli, Claudia ; Sacerdote, Carlotta ; Bonet, Catalina ; Trichopoulou, Antonia ; Gavrila, Diana ; Overvad, Kim ; Weiderpass, Elisabete ; Palli, Domenico ; Quirós, J. Ramón ; Tumino, Rosario ; Khaw, Kay Tee ; Wareham, Nicholas ; Barricante-Gurrea, Aurelio ; Fedirko, Veronika ; Ferrari, Pietro ; Clavel-Chapelon, Françoise ; Ruault, Marie Christine Boutron ; Boeing, Heiner ; Vigl, Matthaeus ; Middleton, Lefkos ; Riboli, Elio ; Vineis, Paolo. / Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis : The EPIC cohort. In: Neurology. 2013 ; Vol. 80, No. 9. pp. 829-838.
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    abstract = "Objectives: The aim of this study was to investigate for the first time the association between body fat and risk of amyotrophic lateral sclerosis (ALS) with an appropriate prospective study design. Methods: The EPIC (European Prospective Investigation into Cancer and Nutrition) study included 518,108 individuals recruited from the general population across 10 Western European countries. At recruitment, information on lifestyle was collected and anthropometric characteristics were measured. Cox hazard models were fitted to investigate the associations between anthropometric measures and ALS mortality. Results: Two hundred twenty-two ALS deaths (79 men and 143 women) occurred during the followup period (mean follow-up 5 13 years). There was a statistically significant interaction between categories of body mass index and sex regarding ALS risk (p 5 0.009): in men, a significant linear decrease of risk per unit of body mass index was observed (hazard ratio 5 0.93, 95{\%} confidence interval 0.86-0.99 per kg/m2); among women, the risk was more than 3-fold increased for underweight compared with normal-weight women. Among women, a significant risk reduction increasing the waist/hip ratio was also evident: women in the top quartile had less than half the risk of ALS compared with those in the bottom quartile (hazard ratio 5 0.48, 95{\%} confidence interval 0.25-0.93) with a borderline significant p value for trend across quartiles (p 5 0.056). Conclusion: Increased prediagnostic body fat is associated with a decreased risk of ALS mortality.",
    author = "Valentina Gallo and Wark, {Petra A.} and Mazda Jenab and Neil Pearce and Carol Brayne and Roel Vermeulen and Andersen, {Peter M.} and Goran Hallmans and Andreas Kyrozis and Nicola Vanacore and Mariam Vahdaninia and Verena Grote and Rudolf Kaaks and Amalia Mattiello and {Bas Bueno-De-mesquita}, H. and Peeters, {Petra H.} and Travis, {Ruth C.} and Jesper Petersson and Oskar Hansson and Larraitz Arriola and Martin, {Juan Manuel Jimenez} and Anne Tj{\o}nneland and Jytte Halkj{\ae}r and Claudia Agnoli and Carlotta Sacerdote and Catalina Bonet and Antonia Trichopoulou and Diana Gavrila and Kim Overvad and Elisabete Weiderpass and Domenico Palli and Quir{\'o}s, {J. Ram{\'o}n} and Rosario Tumino and Khaw, {Kay Tee} and Nicholas Wareham and Aurelio Barricante-Gurrea and Veronika Fedirko and Pietro Ferrari and Fran{\cc}oise Clavel-Chapelon and Ruault, {Marie Christine Boutron} and Heiner Boeing and Matthaeus Vigl and Lefkos Middleton and Elio Riboli and Paolo Vineis",
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    T1 - Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis

    T2 - The EPIC cohort

    AU - Gallo, Valentina

    AU - Wark, Petra A.

    AU - Jenab, Mazda

    AU - Pearce, Neil

    AU - Brayne, Carol

    AU - Vermeulen, Roel

    AU - Andersen, Peter M.

    AU - Hallmans, Goran

    AU - Kyrozis, Andreas

    AU - Vanacore, Nicola

    AU - Vahdaninia, Mariam

    AU - Grote, Verena

    AU - Kaaks, Rudolf

    AU - Mattiello, Amalia

    AU - Bas Bueno-De-mesquita, H.

    AU - Peeters, Petra H.

    AU - Travis, Ruth C.

    AU - Petersson, Jesper

    AU - Hansson, Oskar

    AU - Arriola, Larraitz

    AU - Martin, Juan Manuel Jimenez

    AU - Tjønneland, Anne

    AU - Halkjær, Jytte

    AU - Agnoli, Claudia

    AU - Sacerdote, Carlotta

    AU - Bonet, Catalina

    AU - Trichopoulou, Antonia

    AU - Gavrila, Diana

    AU - Overvad, Kim

    AU - Weiderpass, Elisabete

    AU - Palli, Domenico

    AU - Quirós, J. Ramón

    AU - Tumino, Rosario

    AU - Khaw, Kay Tee

    AU - Wareham, Nicholas

    AU - Barricante-Gurrea, Aurelio

    AU - Fedirko, Veronika

    AU - Ferrari, Pietro

    AU - Clavel-Chapelon, Françoise

    AU - Ruault, Marie Christine Boutron

    AU - Boeing, Heiner

    AU - Vigl, Matthaeus

    AU - Middleton, Lefkos

    AU - Riboli, Elio

    AU - Vineis, Paolo

    PY - 2013/2/26

    Y1 - 2013/2/26

    N2 - Objectives: The aim of this study was to investigate for the first time the association between body fat and risk of amyotrophic lateral sclerosis (ALS) with an appropriate prospective study design. Methods: The EPIC (European Prospective Investigation into Cancer and Nutrition) study included 518,108 individuals recruited from the general population across 10 Western European countries. At recruitment, information on lifestyle was collected and anthropometric characteristics were measured. Cox hazard models were fitted to investigate the associations between anthropometric measures and ALS mortality. Results: Two hundred twenty-two ALS deaths (79 men and 143 women) occurred during the followup period (mean follow-up 5 13 years). There was a statistically significant interaction between categories of body mass index and sex regarding ALS risk (p 5 0.009): in men, a significant linear decrease of risk per unit of body mass index was observed (hazard ratio 5 0.93, 95% confidence interval 0.86-0.99 per kg/m2); among women, the risk was more than 3-fold increased for underweight compared with normal-weight women. Among women, a significant risk reduction increasing the waist/hip ratio was also evident: women in the top quartile had less than half the risk of ALS compared with those in the bottom quartile (hazard ratio 5 0.48, 95% confidence interval 0.25-0.93) with a borderline significant p value for trend across quartiles (p 5 0.056). Conclusion: Increased prediagnostic body fat is associated with a decreased risk of ALS mortality.

    AB - Objectives: The aim of this study was to investigate for the first time the association between body fat and risk of amyotrophic lateral sclerosis (ALS) with an appropriate prospective study design. Methods: The EPIC (European Prospective Investigation into Cancer and Nutrition) study included 518,108 individuals recruited from the general population across 10 Western European countries. At recruitment, information on lifestyle was collected and anthropometric characteristics were measured. Cox hazard models were fitted to investigate the associations between anthropometric measures and ALS mortality. Results: Two hundred twenty-two ALS deaths (79 men and 143 women) occurred during the followup period (mean follow-up 5 13 years). There was a statistically significant interaction between categories of body mass index and sex regarding ALS risk (p 5 0.009): in men, a significant linear decrease of risk per unit of body mass index was observed (hazard ratio 5 0.93, 95% confidence interval 0.86-0.99 per kg/m2); among women, the risk was more than 3-fold increased for underweight compared with normal-weight women. Among women, a significant risk reduction increasing the waist/hip ratio was also evident: women in the top quartile had less than half the risk of ALS compared with those in the bottom quartile (hazard ratio 5 0.48, 95% confidence interval 0.25-0.93) with a borderline significant p value for trend across quartiles (p 5 0.056). Conclusion: Increased prediagnostic body fat is associated with a decreased risk of ALS mortality.

    U2 - 10.1212/WNL.0b013e3182840689

    DO - 10.1212/WNL.0b013e3182840689

    M3 - Article

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    SP - 829

    EP - 838

    JO - Neurology

    JF - Neurology

    SN - 0028-3878

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