Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis: The EPIC cohort

Valentina Gallo, Petra A. Wark, Mazda Jenab, Neil Pearce, Carol Brayne, Roel Vermeulen, Peter M. Andersen, Goran Hallmans, Andreas Kyrozis, Nicola Vanacore, Mariam Vahdaninia, Verena Grote, Rudolf Kaaks, Amalia Mattiello, H. Bas Bueno-De-mesquita, Petra H. Peeters, Ruth C. Travis, Jesper Petersson, Oskar Hansson, Larraitz ArriolaJuan Manuel Jimenez Martin, Anne Tjønneland, Jytte Halkjær, Claudia Agnoli, Carlotta Sacerdote, Catalina Bonet, Antonia Trichopoulou, Diana Gavrila, Kim Overvad, Elisabete Weiderpass, Domenico Palli, J. Ramón Quirós, Rosario Tumino, Kay Tee Khaw, Nicholas Wareham, Aurelio Barricante-Gurrea, Veronika Fedirko, Pietro Ferrari, Françoise Clavel-Chapelon, Marie Christine Boutron Ruault, Heiner Boeing, Matthaeus Vigl, Lefkos Middleton, Elio Riboli, Paolo Vineis

    Research output: Contribution to journalArticlepeer-review

    100 Citations (Scopus)


    Objectives: The aim of this study was to investigate for the first time the association between body fat and risk of amyotrophic lateral sclerosis (ALS) with an appropriate prospective study design. Methods: The EPIC (European Prospective Investigation into Cancer and Nutrition) study included 518,108 individuals recruited from the general population across 10 Western European countries. At recruitment, information on lifestyle was collected and anthropometric characteristics were measured. Cox hazard models were fitted to investigate the associations between anthropometric measures and ALS mortality. Results: Two hundred twenty-two ALS deaths (79 men and 143 women) occurred during the followup period (mean follow-up 5 13 years). There was a statistically significant interaction between categories of body mass index and sex regarding ALS risk (p 5 0.009): in men, a significant linear decrease of risk per unit of body mass index was observed (hazard ratio 5 0.93, 95% confidence interval 0.86-0.99 per kg/m2); among women, the risk was more than 3-fold increased for underweight compared with normal-weight women. Among women, a significant risk reduction increasing the waist/hip ratio was also evident: women in the top quartile had less than half the risk of ALS compared with those in the bottom quartile (hazard ratio 5 0.48, 95% confidence interval 0.25-0.93) with a borderline significant p value for trend across quartiles (p 5 0.056). Conclusion: Increased prediagnostic body fat is associated with a decreased risk of ALS mortality.

    Original languageEnglish
    Pages (from-to)829-838
    Number of pages10
    Issue number9
    Early online date6 Feb 2013
    Publication statusPublished - 26 Feb 2013

    ASJC Scopus subject areas

    • Clinical Neurology


    Dive into the research topics of 'Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis: The EPIC cohort'. Together they form a unique fingerprint.

    Cite this