TY - JOUR
T1 - Prediagnostic 25-hydroxyvitamin D, VDR and CASR polymorphisms, and survival in patients with colorectal cancer in western european populations
AU - Fedirko, Veronika
AU - Riboli, Elio
AU - Tjønneland, Anne
AU - Ferrari, Pietro
AU - Olsen, Anja
AU - Bueno-de-Mesquita, H. Bas
AU - Van Duijnhoven, Fränzel J B
AU - Norat, Teresa
AU - Jansen, Eugène H J M
AU - Dahm, Christina C.
AU - Overvad, Kim
AU - Boutron-Ruault, Marie Christine
AU - Clavel-Chapelon, Françoise
AU - Racine, Antoine
AU - Lukanova, Annekatrin
AU - Teucher, Birgit
AU - Boeing, Heiner
AU - Aleksandrova, Krasimira
AU - Trichopoulou, Antonia
AU - Benetou, Vassiliki
AU - Trichopoulos, Dimitrios
AU - Grioni, Sara
AU - Vineis, Paolo
AU - Panico, Salvatore
AU - Palli, Domenico
AU - Tumino, Rosario
AU - Siersema, Peter D.
AU - Peeters, Petra H.
AU - Skeie, Guri
AU - Brustad, Magritt
AU - Chirlaque, Maria Dolores
AU - Barricarte, Aurelio
AU - Quirós, Jose Ramón
AU - Sánchez, Maria José
AU - Dorronsoro, Miren
AU - Bonet, Catalina
AU - Palmqvist, Richard
AU - Hallmans, Göran
AU - Key, Timothy J.
AU - Crowe, Francesca
AU - Khaw, Kay Tee
AU - Wareham, Nick
AU - Romieu, Isabelle
AU - McKay, James
AU - Wark, Petra A.
AU - Romaguera, Dora
AU - Jenab, Mazda
PY - 2012/4
Y1 - 2012/4
N2 - Background: Individuals with higher blood 25-hydroxyvitamin D [25(OH)D] levels have a lower risk of developing colorectal cancer (CRC), but the influence of 25(OH)D onmortality after CRC diagnosis is unknown. Methods: The association between prediagnostic 25(OH)D levels and CRC-specific (N = 444) and overall mortality (N = 541) was prospectively examined among 1,202 participants diagnosed with CRC between 1992 and 2003 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate HRs and corresponding 95% CIs according to 25(OH)D quintiles and genetic variation within the VDR and CASR genes. Potential dietary, lifestyle, and metabolic effect modifiers were also investigated.Results: There were 541 deaths, 444 (82%) due to CRC. Mean follow-up was 73 months. In multivariable analysis, higher 25(OH)D levels were associated with a statistically significant reduction in CRC-specific (P trend= 0.04) and overall mortality (P trend = 0.01). Participants with 25(OH)D levels in the highest quintile had an adjusted HR of 0.69 (95% CI: 0.50-0.93) for CRC-specific mortality and 0.67 (95% CI: 0.50-0.88) for overall mortality, compared with the lowest quintile. Except for a possible interaction by prediagnostic dietary calcium intake (P interaction = 0.01), no other potential modifying factors related to CRC survival were noted. The VDR (FokI and BsmI) and CASR (rs1801725) genotypes were not associated with survival. Conclusions: High prediagnostic 25(OH)D levels are associated with improved survival of patients with CRC. Impact: Our findings may stimulate further research directed at investigating the effects of blood vitamin D levels before, at, and after CRC diagnosis on outcomes in CRC patients.
AB - Background: Individuals with higher blood 25-hydroxyvitamin D [25(OH)D] levels have a lower risk of developing colorectal cancer (CRC), but the influence of 25(OH)D onmortality after CRC diagnosis is unknown. Methods: The association between prediagnostic 25(OH)D levels and CRC-specific (N = 444) and overall mortality (N = 541) was prospectively examined among 1,202 participants diagnosed with CRC between 1992 and 2003 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate HRs and corresponding 95% CIs according to 25(OH)D quintiles and genetic variation within the VDR and CASR genes. Potential dietary, lifestyle, and metabolic effect modifiers were also investigated.Results: There were 541 deaths, 444 (82%) due to CRC. Mean follow-up was 73 months. In multivariable analysis, higher 25(OH)D levels were associated with a statistically significant reduction in CRC-specific (P trend= 0.04) and overall mortality (P trend = 0.01). Participants with 25(OH)D levels in the highest quintile had an adjusted HR of 0.69 (95% CI: 0.50-0.93) for CRC-specific mortality and 0.67 (95% CI: 0.50-0.88) for overall mortality, compared with the lowest quintile. Except for a possible interaction by prediagnostic dietary calcium intake (P interaction = 0.01), no other potential modifying factors related to CRC survival were noted. The VDR (FokI and BsmI) and CASR (rs1801725) genotypes were not associated with survival. Conclusions: High prediagnostic 25(OH)D levels are associated with improved survival of patients with CRC. Impact: Our findings may stimulate further research directed at investigating the effects of blood vitamin D levels before, at, and after CRC diagnosis on outcomes in CRC patients.
U2 - 10.1158/1055-9965.EPI-11-1065
DO - 10.1158/1055-9965.EPI-11-1065
M3 - Article
C2 - 22278364
AN - SCOPUS:84859396284
SN - 1055-9965
VL - 21
SP - 582
EP - 593
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 4
ER -