Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: A cohort study

Dora Romaguera; Heather Ward; Petra A. Wark; Anne Claire Vergnaud; Petra H. Peeters; Carla H. van Gils; Pietro Ferrari; Veronika Fedirko; Mazda Jenab; Marie Christine Boutron-Ruault; Laure Dossus; Laureen Dartois; Camilla Plambeck Hansen; Christina Catherine Dahm; Genevieve Buckland; María José Sánchez; Miren Dorronsoro; Carmen Navarro; Aurelio Barricarte; Timothy J. Key; Antonia Trichopoulou; Christos Tsironis; Pagona Lagiou; Giovanna Masala; Valeria Pala; Rosario Tumino; Paolo Vineis; Salvatore Panico; H. Bas Bueno-de-Mesquita; Peter D. Siersema; Bodil Ohlsson; Karin Jirström; Maria Wennberg; Lena M. Nilsson; Elisabete Weiderpass; Tilman Kühn; Verena Katzke; Kay Tee Khaw; Nick J. Wareham; Anne Tjønneland; Heiner Boeing; José R. Quirós; Marc J. Gunter; Elio Riboli; Teresa Norat

doi:10.1186/s12916-015-0332-5

Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: A cohort study

Dora Romaguera
, Heather Ward
, Petra A. Wark
, Anne Claire Vergnaud
, Petra H. Peeters
, Carla H. van Gils
, Pietro Ferrari
, Veronika Fedirko
, Mazda Jenab
, Marie Christine Boutron-Ruault
, Laure Dossus
, Laureen Dartois
, Camilla Plambeck Hansen
, Christina Catherine Dahm
, Genevieve Buckland
, María José Sánchez
, Miren Dorronsoro
, Carmen Navarro
, Aurelio Barricarte
, Timothy J. Key

Antonia Trichopoulou, Christos Tsironis, Pagona Lagiou, Giovanna Masala, Valeria Pala, Rosario Tumino, Paolo Vineis, Salvatore Panico, H. Bas Bueno-de-Mesquita, Peter D. Siersema, Bodil Ohlsson, Karin Jirström, Maria Wennberg, Lena M. Nilsson, Elisabete Weiderpass, Tilman Kühn, Verena Katzke, Kay Tee Khaw, Nick J. Wareham, Anne Tjønneland, Heiner Boeing, José R. Quirós, Marc J. Gunter, Elio Riboli, Teresa Norat

Health Institute Carlos III
Imperial College London
University of Utrecht
International Agency for Research on Cancer
Emory University
Institut Gustave Roussy
Aarhus University
Catalan Institute of Oncology
Public Health Direction Biodonostia Basque Regional Health Department
Universidad de Murcia
Navarra Public Health Institute
University of Oxford
Academy of Athens
Hellenic Health Foundation
Harvard University
Institute for the Study and Prevention of Cancer
Fondazione IRCCS Istituto Nazionale dei Tumori
Azienda Sanitaria Provinciale di Ragusa (ASP Ragusa)
HuGeF Foundation
Federico II University
Universiti Malaya
Lund University
Umeå University
University of Helsinki
German Cancer Research Center (DKFZ)
University of Cambridge
Danish Cancer Society Research Center
German Institute of Human Nutrition
Public Health Directorate
Hospital Universitario Son Espases
CESP Centre for Research in Epidemiology and Population Health
Université Paris-Sud
CIBER de Epidemiología y Salud Pública (CIBERESP)
National Institute for Public Health and the Environment
University of Tromsø
Cancer Registry of Norway
Karolinska Institutet

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

65 Downloads (Pure)

Abstract

Background

Cancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for cancer prevention. Previous studies have demonstrated that higher concordance with these recommendations measured using an index score (the WCRF/AICR score) was associated with lower cancer incidence and mortality. The aim of this study was to evaluate the association between pre-diagnostic concordance with WCRF/AICR recommendations and mortality in colorectal cancer (CRC) patients.

Methods

The association between the WCRF/AICR score (score range 0–6 in men and 0–7 in women; higher scores indicate greater concordance) assessed on average 6.4 years before diagnosis and CRC-specific (n = 872) and overall mortality (n = 1,113) was prospectively examined among 3,292 participants diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (mean follow-up time after diagnosis 4.2 years). Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality.

Results

The HRs (95% CIs) for CRC-specific mortality among participants in the second (score range in men/women: 2.25–2.75/3.25–3.75), third (3–3.75/4–4.75), and fourth (4–6/5–7) categories of the score were 0.87 (0.72–1.06), 0.74 (0.61–0.90), and 0.70 (0.56–0.89), respectively (P for trend <0.0001), compared to participants with the lowest concordance with the recommendations (category 1 of the score: 0–2/0–3). Similar HRs for overall mortality were observed (P for trend 0.004). Meeting the recommendations on body fatness and plant food consumption were associated with improved survival among CRC cases in mutually adjusted models.

Conclusions

Greater concordance with the WCRF/AICR recommendations on diet, physical activity, and body fatness prior to CRC diagnosis is associated with improved survival among CRC patients.

Original language	English
Article number	107
Journal	BMC Medicine
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/s12916-015-0332-5
Publication status	Published - 7 May 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Colorectal cancer
Diet
Healthy lifestyle
Physical activity
Survival
Weight

ASJC Scopus subject areas

General Medicine

Access to Document

10.1186/s12916-015-0332-5Licence: CC BY

PublishedFinal published version, 682 KBLicence: CC BY

Petra Wark
- Centre for Healthcare and Community Transformation (HCT) - Professor
Person: Teaching and Research

Cite this

Romaguera, D., Ward, H., Wark, P. A., Vergnaud, A. C., Peeters, P. H., van Gils, C. H., Ferrari, P., Fedirko, V., Jenab, M., Boutron-Ruault, M. C., Dossus, L., Dartois, L., Hansen, C. P., Dahm, C. C., Buckland, G., Sánchez, M. J., Dorronsoro, M., Navarro, C., Barricarte, A., ... Norat, T. (2015). Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: A cohort study. BMC Medicine, 13(1), Article 107. https://doi.org/10.1186/s12916-015-0332-5

Romaguera, D, Ward, H, Wark, PA, Vergnaud, AC, Peeters, PH, van Gils, CH, Ferrari, P, Fedirko, V, Jenab, M, Boutron-Ruault, MC, Dossus, L, Dartois, L, Hansen, CP, Dahm, CC, Buckland, G, Sánchez, MJ, Dorronsoro, M, Navarro, C, Barricarte, A, Key, TJ, Trichopoulou, A, Tsironis, C, Lagiou, P, Masala, G, Pala, V, Tumino, R, Vineis, P, Panico, S, Bueno-de-Mesquita, HB, Siersema, PD, Ohlsson, B, Jirström, K, Wennberg, M, Nilsson, LM, Weiderpass, E, Kühn, T, Katzke, V, Khaw, KT, Wareham, NJ, Tjønneland, A, Boeing, H, Quirós, JR, Gunter, MJ, Riboli, E & Norat, T 2015, 'Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: A cohort study', BMC Medicine, vol. 13, no. 1, 107. https://doi.org/10.1186/s12916-015-0332-5

@article{7041a39354f34a8888b4ba70ba4b02b1,

title = "Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: A cohort study",

abstract = "BackgroundCancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for cancer prevention. Previous studies have demonstrated that higher concordance with these recommendations measured using an index score (the WCRF/AICR score) was associated with lower cancer incidence and mortality. The aim of this study was to evaluate the association between pre-diagnostic concordance with WCRF/AICR recommendations and mortality in colorectal cancer (CRC) patients.MethodsThe association between the WCRF/AICR score (score range 0–6 in men and 0–7 in women; higher scores indicate greater concordance) assessed on average 6.4 years before diagnosis and CRC-specific (n = 872) and overall mortality (n = 1,113) was prospectively examined among 3,292 participants diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (mean follow-up time after diagnosis 4.2 years). Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95\% confidence intervals (CIs) for mortality.ResultsThe HRs (95\% CIs) for CRC-specific mortality among participants in the second (score range in men/women: 2.25–2.75/3.25–3.75), third (3–3.75/4–4.75), and fourth (4–6/5–7) categories of the score were 0.87 (0.72–1.06), 0.74 (0.61–0.90), and 0.70 (0.56–0.89), respectively (P for trend <0.0001), compared to participants with the lowest concordance with the recommendations (category 1 of the score: 0–2/0–3). Similar HRs for overall mortality were observed (P for trend 0.004). Meeting the recommendations on body fatness and plant food consumption were associated with improved survival among CRC cases in mutually adjusted models.ConclusionsGreater concordance with the WCRF/AICR recommendations on diet, physical activity, and body fatness prior to CRC diagnosis is associated with improved survival among CRC patients.",

keywords = "Colorectal cancer, Diet, Healthy lifestyle, Physical activity, Survival, Weight",

author = "Dora Romaguera and Heather Ward and Wark, \{Petra A.\} and Vergnaud, \{Anne Claire\} and Peeters, \{Petra H.\} and \{van Gils\}, \{Carla H.\} and Pietro Ferrari and Veronika Fedirko and Mazda Jenab and Boutron-Ruault, \{Marie Christine\} and Laure Dossus and Laureen Dartois and Hansen, \{Camilla Plambeck\} and Dahm, \{Christina Catherine\} and Genevieve Buckland and S{\'a}nchez, \{Mar{\'i}a Jos{\'e}\} and Miren Dorronsoro and Carmen Navarro and Aurelio Barricarte and Key, \{Timothy J.\} and Antonia Trichopoulou and Christos Tsironis and Pagona Lagiou and Giovanna Masala and Valeria Pala and Rosario Tumino and Paolo Vineis and Salvatore Panico and Bueno-de-Mesquita, \{H. Bas\} and Siersema, \{Peter D.\} and Bodil Ohlsson and Karin Jirstr{\"o}m and Maria Wennberg and Nilsson, \{Lena M.\} and Elisabete Weiderpass and Tilman K{\"u}hn and Verena Katzke and Khaw, \{Kay Tee\} and Wareham, \{Nick J.\} and Anne Tj{\o}nneland and Heiner Boeing and Quir{\'o}s, \{Jos{\'e} R.\} and Gunter, \{Marc J.\} and Elio Riboli and Teresa Norat",

year = "2015",

month = may,

day = "7",

doi = "10.1186/s12916-015-0332-5",

language = "English",

volume = "13",

journal = "BMC Medicine",

issn = "1468-1293",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "1",

}

TY - JOUR

T1 - Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients

T2 - A cohort study

AU - Romaguera, Dora

AU - Ward, Heather

AU - Wark, Petra A.

AU - Vergnaud, Anne Claire

AU - Peeters, Petra H.

AU - van Gils, Carla H.

AU - Ferrari, Pietro

AU - Fedirko, Veronika

AU - Jenab, Mazda

AU - Boutron-Ruault, Marie Christine

AU - Dossus, Laure

AU - Dartois, Laureen

AU - Hansen, Camilla Plambeck

AU - Dahm, Christina Catherine

AU - Buckland, Genevieve

AU - Sánchez, María José

AU - Dorronsoro, Miren

AU - Navarro, Carmen

AU - Barricarte, Aurelio

AU - Key, Timothy J.

AU - Trichopoulou, Antonia

AU - Tsironis, Christos

AU - Lagiou, Pagona

AU - Masala, Giovanna

AU - Pala, Valeria

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Panico, Salvatore

AU - Bueno-de-Mesquita, H. Bas

AU - Siersema, Peter D.

AU - Ohlsson, Bodil

AU - Jirström, Karin

AU - Wennberg, Maria

AU - Nilsson, Lena M.

AU - Weiderpass, Elisabete

AU - Kühn, Tilman

AU - Katzke, Verena

AU - Khaw, Kay Tee

AU - Wareham, Nick J.

AU - Tjønneland, Anne

AU - Boeing, Heiner

AU - Quirós, José R.

AU - Gunter, Marc J.

AU - Riboli, Elio

AU - Norat, Teresa

PY - 2015/5/7

Y1 - 2015/5/7

N2 - BackgroundCancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for cancer prevention. Previous studies have demonstrated that higher concordance with these recommendations measured using an index score (the WCRF/AICR score) was associated with lower cancer incidence and mortality. The aim of this study was to evaluate the association between pre-diagnostic concordance with WCRF/AICR recommendations and mortality in colorectal cancer (CRC) patients.MethodsThe association between the WCRF/AICR score (score range 0–6 in men and 0–7 in women; higher scores indicate greater concordance) assessed on average 6.4 years before diagnosis and CRC-specific (n = 872) and overall mortality (n = 1,113) was prospectively examined among 3,292 participants diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (mean follow-up time after diagnosis 4.2 years). Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality.ResultsThe HRs (95% CIs) for CRC-specific mortality among participants in the second (score range in men/women: 2.25–2.75/3.25–3.75), third (3–3.75/4–4.75), and fourth (4–6/5–7) categories of the score were 0.87 (0.72–1.06), 0.74 (0.61–0.90), and 0.70 (0.56–0.89), respectively (P for trend <0.0001), compared to participants with the lowest concordance with the recommendations (category 1 of the score: 0–2/0–3). Similar HRs for overall mortality were observed (P for trend 0.004). Meeting the recommendations on body fatness and plant food consumption were associated with improved survival among CRC cases in mutually adjusted models.ConclusionsGreater concordance with the WCRF/AICR recommendations on diet, physical activity, and body fatness prior to CRC diagnosis is associated with improved survival among CRC patients.

AB - BackgroundCancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for cancer prevention. Previous studies have demonstrated that higher concordance with these recommendations measured using an index score (the WCRF/AICR score) was associated with lower cancer incidence and mortality. The aim of this study was to evaluate the association between pre-diagnostic concordance with WCRF/AICR recommendations and mortality in colorectal cancer (CRC) patients.MethodsThe association between the WCRF/AICR score (score range 0–6 in men and 0–7 in women; higher scores indicate greater concordance) assessed on average 6.4 years before diagnosis and CRC-specific (n = 872) and overall mortality (n = 1,113) was prospectively examined among 3,292 participants diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (mean follow-up time after diagnosis 4.2 years). Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality.ResultsThe HRs (95% CIs) for CRC-specific mortality among participants in the second (score range in men/women: 2.25–2.75/3.25–3.75), third (3–3.75/4–4.75), and fourth (4–6/5–7) categories of the score were 0.87 (0.72–1.06), 0.74 (0.61–0.90), and 0.70 (0.56–0.89), respectively (P for trend <0.0001), compared to participants with the lowest concordance with the recommendations (category 1 of the score: 0–2/0–3). Similar HRs for overall mortality were observed (P for trend 0.004). Meeting the recommendations on body fatness and plant food consumption were associated with improved survival among CRC cases in mutually adjusted models.ConclusionsGreater concordance with the WCRF/AICR recommendations on diet, physical activity, and body fatness prior to CRC diagnosis is associated with improved survival among CRC patients.

KW - Colorectal cancer

KW - Diet

KW - Healthy lifestyle

KW - Physical activity

KW - Survival

KW - Weight

U2 - 10.1186/s12916-015-0332-5

DO - 10.1186/s12916-015-0332-5

M3 - Article

C2 - 25948112

AN - SCOPUS:84939583778

SN - 1468-1293

SN - 1741-7015

VL - 13

JO - BMC Medicine

JF - BMC Medicine

IS - 1

M1 - 107

ER -

Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: A cohort study

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Petra Wark

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