Potential risk factors of persistent postural-perceptual dizziness: a pilot study

Ling Li, Songbin He, Haipeng Liu, Meilun Pan, Fangyu Dai

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    Background: Persistent postural-perceptual dizziness (PPPD) unifies the main characteristics of chronic subjective dizziness, visual vertigo and related diseases, which is a common chronic disease in neurology. At present, the pathology of PPPD is not fully understood. Objective: In this single-center retrospective case series review, we aim to investigate the potential risk factors of PPPD. Methods: Eighty inpatients diagnosed with PPPD were recruited with 81 apparently healthy controls. Patient-specific clinico-radiological data were collected from both groups. Conditions of hypertension, diabetes, smoking, and drinking were derived from medical history. Blood test results were recorded including total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fibrinogen, vitamin B12, folic acid, total cholesterol, triglyceride, and folate level. The subjects were examined by carotid artery CTA and cranial MRI, and the imaging findings of carotid atherosclerosis (CAS), white matter hyperintensities (WMHs) and lacunar infarction (LI) were recorded. Binary logistic regression analysis was used to investigate the difference between the case and control groups. Significance was defined as p value less than 0.05. Results: The prevalence rate of hypertension in the case group was significantly higher than that in the control group, and the detection rates of CAS, WMHs, and LI in the case group were significantly higher than those in the control group (p < 0.05 for all). Conclusion: Hypertension, CAS, WMHs, and LI are associated with PPPD, which may be potential risk factors for its development.

    Original languageEnglish
    Pages (from-to)3075-3085
    Number of pages11
    JournalJournal of Neurology
    Issue number6
    Early online date20 Nov 2021
    Publication statusPublished - Jun 2022

    Bibliographical note

    The final publication is available at Springer via http://dx.doi.org/ 10.1007/s00415-021-10899-7 Copyright © and Moral Rights are retained by the author(s) and/ or other copyright
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    • Vestibular system dysfunction
    • Clinico-radiological characteristics
    • Persistent posture-perceptual dizziness
    • Potential risk factor
    • Binary logistic regression analysis


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