Plasma membrane targeting of exocytic SNARE proteins

Christine Salaün, Declan J James, Jennifer Greaves, Luke H. Chamberlain

Research output: Contribution to journalReview articlepeer-review

64 Citations (Scopus)


SNARE proteins play a central role in the process of intracellular membrane fusion. Indeed, the interaction of SNAREs present on two opposing membranes is generally believed to provide the driving force to initiate membrane fusion. Eukaryotic cells express a large number of SNARE isoforms, and the function of individual SNAREs is required for specific intracellular fusion events. Exocytosis, the fusion of secretory vesicles with the plasma membrane, employs the proteins syntaxin and SNAP-25 as plasma membrane SNAREs. As a result, exocytosis is dependent upon the targeting of these proteins to the plasma membrane; however, the mechanisms that underlie trafficking of exocytic syntaxin and SNAP-25 proteins to the cell surface are poorly understood. The intracellular trafficking itinerary of these proteins is particularly intriguing as syntaxins are tail-anchored (or Type IV) membrane proteins, whereas SNAP-25 is anchored to membranes via a central palmitoylated domain-there is no common consensus for the trafficking of such proteins within the cell. In this review, we discuss the plasma membrane targeting of these essential exocytic SNARE proteins.

Original languageEnglish
Pages (from-to)81-89
Number of pages9
JournalBiochimica et biophysica acta
Issue number2
Publication statusPublished - 23 Aug 2004


  • Animals
  • Cell Membrane
  • Exocytosis
  • Humans
  • Membrane Proteins
  • Munc18 Proteins
  • Nerve Tissue Proteins
  • Qa-SNARE Proteins
  • SNARE Proteins
  • Synaptosomal-Associated Protein 25
  • Vesicular Transport Proteins
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review


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