TY - JOUR
T1 - Plasma and dietary carotenoids and vitamins A, C and e and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition
AU - Leenders, Max
AU - Leufkens, Anke M.
AU - Siersema, Peter D.
AU - Van Duijnhoven, Fränzel J B
AU - Vrieling, Alina
AU - Hulshof, Paul J M
AU - Van Gils, Carla H.
AU - Overvad, Kim
AU - Roswall, Nina
AU - Kyrø, Cecilie
AU - Boutron-Ruault, Marie Christine
AU - Fagerhazzi, Guy
AU - Cadeau, Claire
AU - Kühn, Tilman
AU - Johnson, Theron
AU - Boeing, Heiner
AU - Aleksandrova, Krasimira
AU - Trichopoulou, Antonia
AU - Klinaki, Eleni
AU - Androulidaki, Anna
AU - Palli, Domenico
AU - Grioni, Sara
AU - Sacerdote, Carlotta
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Bakker, Marije F.
AU - Skeie, Guri
AU - Weiderpass, Elisabete
AU - Jakszyn, Paula
AU - Barricarte, Aurelio
AU - Huerta, José María
AU - Molina-Montes, Esther
AU - Argüelles, Marcial
AU - Johansson, Ingegerd
AU - Ljuslinder, Ingrid
AU - Key, Timothy J.
AU - Bradbury, Kathryn E.
AU - Khaw, Kay Tee
AU - Wareham, Nicholas J.
AU - Ferrari, Pietro
AU - Duarte-Salles, Talita
AU - Jenab, Mazda
AU - Gunter, Marc J.
AU - Vergnaud, Anne Claire
AU - Wark, Petra A.
AU - Bueno-de-Mesquita, H. B.
PY - 2014/12/15
Y1 - 2014/12/15
N2 - Carotenoids and vitamins A, C and E are possibly associated with a reduced colorectal cancer (CRC) risk through antioxidative properties. The association of prediagnostic plasma concentrations and dietary consumption of carotenoids and vitamins A, C and E with the risk of colon and rectal cancer was examined in this case-control study, nested within the European Prospective Investigation into Cancer and Nutrition study. Plasma concentrations of carotenoids (α- and β-carotene, canthaxanthin, βcryptoxanthin, lutein, lycopene, zeaxanthin) and vitamins A (retinol), C and E (α-, β- and γ- and δ-tocopherol) and dietary consumption of β-carotene and vitamins A, C and E were determined in 898 colon cancer cases, 501 rectal cancer cases and 1,399 matched controls. Multivariable conditional logistic regression models were performed to estimate incidence rate ratios (IRR) and corresponding 95% confidence intervals (CIs). An association was observed between higher prediagnostic plasma retinol concentration and a lower risk of colon cancer (IRR for highest quartile = 0.63, 95% CI: 0.46, 0.87, p for trend=0.01), most notably proximal colon cancer (IRR for highest quartile = 0.46, 95% CI: 0.27, 0.77, p for trend = 0.01). Additionally, inverse associations for dietary β-carotene and dietary vitamins C and E with (distal) colon cancer were observed. Although other associations were suggested, there seems little evidence for a role of these selected compounds in preventing CRC through their antioxidative properties.
AB - Carotenoids and vitamins A, C and E are possibly associated with a reduced colorectal cancer (CRC) risk through antioxidative properties. The association of prediagnostic plasma concentrations and dietary consumption of carotenoids and vitamins A, C and E with the risk of colon and rectal cancer was examined in this case-control study, nested within the European Prospective Investigation into Cancer and Nutrition study. Plasma concentrations of carotenoids (α- and β-carotene, canthaxanthin, βcryptoxanthin, lutein, lycopene, zeaxanthin) and vitamins A (retinol), C and E (α-, β- and γ- and δ-tocopherol) and dietary consumption of β-carotene and vitamins A, C and E were determined in 898 colon cancer cases, 501 rectal cancer cases and 1,399 matched controls. Multivariable conditional logistic regression models were performed to estimate incidence rate ratios (IRR) and corresponding 95% confidence intervals (CIs). An association was observed between higher prediagnostic plasma retinol concentration and a lower risk of colon cancer (IRR for highest quartile = 0.63, 95% CI: 0.46, 0.87, p for trend=0.01), most notably proximal colon cancer (IRR for highest quartile = 0.46, 95% CI: 0.27, 0.77, p for trend = 0.01). Additionally, inverse associations for dietary β-carotene and dietary vitamins C and E with (distal) colon cancer were observed. Although other associations were suggested, there seems little evidence for a role of these selected compounds in preventing CRC through their antioxidative properties.
KW - Antioxidants
KW - Carotenoids
KW - Colorectal cancer
KW - Fruits and vegetables
KW - Vitamins
U2 - 10.1002/ijc.28938
DO - 10.1002/ijc.28938
M3 - Article
C2 - 24771392
AN - SCOPUS:84905586081
SN - 0020-7136
VL - 135
SP - 2930
EP - 2939
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 12
ER -
