Physical Activity, Inactivity and Sleep in Individuals with Hypertrophic Cardiomyopathy

Sarah J Charman, Alasdair P Blain, Nduka Okwose, Amy Fuller, Alaa I Alyahya, Kate Hallsworth, Christopher Eggett, Peter Luke, Kristian Bailey, Guy A MacGowan, Djordje Jakovljevic

Research output: Contribution to journalArticlepeer-review


Physical activity presents an important cornerstone in the management and care of individuals with hypertrophic cardiomyopathy (HCM). Twenty-one individuals with HCM (age: 52±15 years old, body mass index (BMI): 30±7 kg/m 2) completed 7-day monitoring using wrist-worn triaxial accelerometers (GENEActiv, ActivInsights Ltd, UK) and were compared to age and sex-matched healthy controls (age: 51±14 years old, BMI: 25±4 kg/m 2). For individuals with HCM, clinical parameters (left atrial diameter and volume, peak oxygen consumption, NTproBNP and Minnesota Living with Heart Failure (MLHF)) were correlated with accelerometry. After adjusting for BMI, individuals with HCM spent less time in moderate-vigorous physical activity (MVPA) (86 (55-138) vs. 140 (121-149) minutes/day, p <0.05) compared to healthy controls. Individuals with HCM engaged in fewer MVPA-5 min (6 (2-15) vs. 27 (23-37) minutes/day, p <0.01) and MVPA-10 min bouts (9 (0-19) vs. 35 (17-54) minutes/day, p <0.01) versus healthy controls. For HCM only, peak oxygen consumption was correlated with MVPA (r =0.60, p <0.01) and MVPA-5 min bouts (r =0.47, p <0.05). MLHF score was correlated with slee p duration (r =0.45, p <0.05). Individuals with HCM should be encouraged to engage in moderate-intensity physical activity bouts and reduce prolonged periods of inactivity in order to potentially improve exercise tolerance and reduce disease burden.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalInternational Journal of Sports Medicine
Issue number2
Early online date27 Oct 2023
Publication statusE-pub ahead of print - 27 Oct 2023


European Union’s Horizon 2020 Research and Innovation Programme – Grant number 777204


  • myopathy
  • cardiology
  • physical activity
  • sleep


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