TY - JOUR
T1 - Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study
AU - Gallo, Valentina
AU - Vanacore, Nicola
AU - Bueno-de-Mesquita, H. Bas
AU - Vermeulen, Roel
AU - Brayne, Carol
AU - Pearce, Neil
AU - Wark, Petra A.
AU - Ward, Heather A.
AU - Ferrari, Pietro
AU - Jenab, Mazda
AU - Andersen, Peter M.
AU - Wennberg, Patrik
AU - Wareham, Nicholas
AU - Katzke, Verena
AU - Kaaks, Rudolf
AU - Weiderpass, Elisabete
AU - Peeters, Petra H.
AU - Mattiello, Amalia
AU - Pala, Valeria
AU - Barricante, Aurelio
AU - Chirlaque, Maria Dolores
AU - Travier, Noémie
AU - Travis, Ruth C.
AU - Sanchez, Maria Jose
AU - Pessah-Rasmussen, Hélène
AU - Petersson, Jesper
AU - Tjønneland, Anne
AU - Tumino, Rosario
AU - Quiros, Jose Ramon
AU - Trichopoulou, Antonia
AU - Kyrozis, Andreas
AU - Oikonomidou, Despoina
AU - Masala, Giovanna
AU - Sacerdote, Carlotta
AU - Arriola, Larraitz
AU - Boeing, Heiner
AU - Vigl, Matthaeus
AU - Claver-Chapelon, Francoise
AU - Middleton, Lefkos
AU - Riboli, Elio
AU - Vineis, Paolo
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Previous case–control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included in the analysis, yielding 219 ALS deaths. At recruitment, information on PA was collected thorough standardised questionnaires. Total PA was expressed by the Cambridge Physical Activity Index (CPAI) and analysed in relation to ALS mortality, using Cox hazard models. Interactions with age, sex, and anthropometric measures were assessed. Total PA was weakly inversely associated with ALS mortality with a borderline statistically significant trend across categories (p = 0.042), with those physically active being 33 % less likely to die from ALS compared to those inactive: HR = 0.67 (95 % CI 0.42–1.06). Anthropometric measures, sex, and age did not modify the association with CPAI. The present study shows a slightly decreased—not increased like in case–control studies—risk of dying from ALS in those with high levels of total PA at enrolment. This association does not appear confounded by age, gender, anthropometry, smoking, and education. Ours was the first prospective cohort study on ALS and physical activity.
AB - Previous case–control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included in the analysis, yielding 219 ALS deaths. At recruitment, information on PA was collected thorough standardised questionnaires. Total PA was expressed by the Cambridge Physical Activity Index (CPAI) and analysed in relation to ALS mortality, using Cox hazard models. Interactions with age, sex, and anthropometric measures were assessed. Total PA was weakly inversely associated with ALS mortality with a borderline statistically significant trend across categories (p = 0.042), with those physically active being 33 % less likely to die from ALS compared to those inactive: HR = 0.67 (95 % CI 0.42–1.06). Anthropometric measures, sex, and age did not modify the association with CPAI. The present study shows a slightly decreased—not increased like in case–control studies—risk of dying from ALS in those with high levels of total PA at enrolment. This association does not appear confounded by age, gender, anthropometry, smoking, and education. Ours was the first prospective cohort study on ALS and physical activity.
KW - Amyotrophic Lateral Sclerosis
KW - BMI
KW - Cohort study
KW - EPIC study
KW - Physical activity
KW - Vigorous physical activity
U2 - 10.1007/s10654-016-0119-9
DO - 10.1007/s10654-016-0119-9
M3 - Article
AN - SCOPUS:84960399820
SN - 0393-2990
VL - 31
SP - 255
EP - 266
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 3
ER -
