Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study

Valentina Gallo, Nicola Vanacore, H. Bas Bueno-de-Mesquita, Roel Vermeulen, Carol Brayne, Neil Pearce, Petra A. Wark, Heather A. Ward, Pietro Ferrari, Mazda Jenab, Peter M. Andersen, Patrik Wennberg, Nicholas Wareham, Verena Katzke, Rudolf Kaaks, Elisabete Weiderpass, Petra H. Peeters, Amalia Mattiello, Valeria Pala, Aurelio BarricanteMaria Dolores Chirlaque, Noémie Travier, Ruth C. Travis, Maria Jose Sanchez, Hélène Pessah-Rasmussen, Jesper Petersson, Anne Tjønneland, Rosario Tumino, Jose Ramon Quiros, Antonia Trichopoulou, Andreas Kyrozis, Despoina Oikonomidou, Giovanna Masala, Carlotta Sacerdote, Larraitz Arriola, Heiner Boeing, Matthaeus Vigl, Francoise Claver-Chapelon, Lefkos Middleton, Elio Riboli, Paolo Vineis

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    40 Citations (Scopus)
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    Previous case–control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included in the analysis, yielding 219 ALS deaths. At recruitment, information on PA was collected thorough standardised questionnaires. Total PA was expressed by the Cambridge Physical Activity Index (CPAI) and analysed in relation to ALS mortality, using Cox hazard models. Interactions with age, sex, and anthropometric measures were assessed. Total PA was weakly inversely associated with ALS mortality with a borderline statistically significant trend across categories (p = 0.042), with those physically active being 33 % less likely to die from ALS compared to those inactive: HR = 0.67 (95 % CI 0.42–1.06). Anthropometric measures, sex, and age did not modify the association with CPAI. The present study shows a slightly decreased—not increased like in case–control studies—risk of dying from ALS in those with high levels of total PA at enrolment. This association does not appear confounded by age, gender, anthropometry, smoking, and education. Ours was the first prospective cohort study on ALS and physical activity.

    Original languageEnglish
    Pages (from-to)255-266
    Number of pages12
    JournalEuropean Journal of Epidemiology
    Issue number3
    Publication statusPublished - 1 Mar 2016


    • Amyotrophic Lateral Sclerosis
    • BMI
    • Cohort study
    • EPIC study
    • Physical activity
    • Vigorous physical activity

    ASJC Scopus subject areas

    • Epidemiology


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