Physical Activity and Alzheimer’s Disease: A Narrative Review

Piotr Gronek, Štefan Balkó, Joanna Gronek, Adam Zając, Adam Maszczyk, Roman Celka, Agnieszka Doberska, Wojciech Czarny, Robert Podstawski, Cain Clark, Fang Yu

Research output: Contribution to journalArticle

4 Downloads (Pure)

Abstract

Although age is a dominant risk factor for Alzheimer’s disease (AD), epidemiological studies have shown that physical activity may significantly decrease age-related risks for AD, and indeed mitigate the impact in existing diagnosis. The aim of this study was to perform a narrative review on the preventative, and mitigating, effects of physical activity on AD onset, including genetic factors, mechanism of action and physical activity typology. In this article, we conducted a narrative review of the influence physical activity and exercise have on AD, utilising key terms related to AD, physical activity, mechanism and prevention, searching the online databases; Web of Science, PubMed and Google Scholar, and, subsequently, discuss possible mechanisms of this action. On the basis of this review, it is evident that physical activity and exercise may be incorporated in AD, notwithstanding, a greater number of high-quality randomised controlled trials are needed, moreover, physical activity typology must be acutely considered, primarily due to a dearth of research on the efficacy of physical activity types other than aerobic.
Original languageEnglish
Number of pages11
JournalAging and Disease
Volume10
Issue number6
Early online date12 Mar 2019
DOIs
Publication statusPublished - Dec 2019

Fingerprint

Alzheimer Disease
Exercise
PubMed
Epidemiologic Studies
Randomized Controlled Trials
Databases
Research

Bibliographical note

Copyright: © 2019 Gronek P et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
I

Keywords

  • Alzheimer’s
  • Prevention
  • Physical Activity
  • Exercise
  • Aging

Cite this

Gronek, P., Balkó, Š., Gronek, J., Zając, A., Maszczyk, A., Celka, R., ... Yu, F. (2019). Physical Activity and Alzheimer’s Disease: A Narrative Review. Aging and Disease, 10(6). https://doi.org/10.14336/AD.2019.0226

Physical Activity and Alzheimer’s Disease: A Narrative Review. / Gronek, Piotr; Balkó, Štefan ; Gronek, Joanna; Zając, Adam ; Maszczyk, Adam ; Celka, Roman ; Doberska, Agnieszka ; Czarny, Wojciech ; Podstawski, Robert; Clark, Cain; Yu, Fang.

In: Aging and Disease, Vol. 10, No. 6, 12.2019.

Research output: Contribution to journalArticle

Gronek, P, Balkó, Š, Gronek, J, Zając, A, Maszczyk, A, Celka, R, Doberska, A, Czarny, W, Podstawski, R, Clark, C & Yu, F 2019, 'Physical Activity and Alzheimer’s Disease: A Narrative Review' Aging and Disease, vol. 10, no. 6. https://doi.org/10.14336/AD.2019.0226
Gronek P, Balkó Š, Gronek J, Zając A, Maszczyk A, Celka R et al. Physical Activity and Alzheimer’s Disease: A Narrative Review. Aging and Disease. 2019 Dec;10(6). https://doi.org/10.14336/AD.2019.0226
Gronek, Piotr ; Balkó, Štefan ; Gronek, Joanna ; Zając, Adam ; Maszczyk, Adam ; Celka, Roman ; Doberska, Agnieszka ; Czarny, Wojciech ; Podstawski, Robert ; Clark, Cain ; Yu, Fang. / Physical Activity and Alzheimer’s Disease: A Narrative Review. In: Aging and Disease. 2019 ; Vol. 10, No. 6.
@article{7024aebd6ab84ea58010b563e62d7029,
title = "Physical Activity and Alzheimer’s Disease: A Narrative Review",
abstract = "Although age is a dominant risk factor for Alzheimer’s disease (AD), epidemiological studies have shown that physical activity may significantly decrease age-related risks for AD, and indeed mitigate the impact in existing diagnosis. The aim of this study was to perform a narrative review on the preventative, and mitigating, effects of physical activity on AD onset, including genetic factors, mechanism of action and physical activity typology. In this article, we conducted a narrative review of the influence physical activity and exercise have on AD, utilising key terms related to AD, physical activity, mechanism and prevention, searching the online databases; Web of Science, PubMed and Google Scholar, and, subsequently, discuss possible mechanisms of this action. On the basis of this review, it is evident that physical activity and exercise may be incorporated in AD, notwithstanding, a greater number of high-quality randomised controlled trials are needed, moreover, physical activity typology must be acutely considered, primarily due to a dearth of research on the efficacy of physical activity types other than aerobic.",
keywords = "Alzheimer’s, Prevention, Physical Activity, Exercise, Aging",
author = "Piotr Gronek and Štefan Balk{\'o} and Joanna Gronek and Adam Zając and Adam Maszczyk and Roman Celka and Agnieszka Doberska and Wojciech Czarny and Robert Podstawski and Cain Clark and Fang Yu",
note = "Copyright: {\circledC} 2019 Gronek P et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. I",
year = "2019",
month = "12",
doi = "10.14336/AD.2019.0226",
language = "English",
volume = "10",
journal = "Aging and Disease",
issn = "2152-5250",
publisher = "Buck Institute for Age Research",
number = "6",

}

TY - JOUR

T1 - Physical Activity and Alzheimer’s Disease: A Narrative Review

AU - Gronek, Piotr

AU - Balkó, Štefan

AU - Gronek, Joanna

AU - Zając, Adam

AU - Maszczyk, Adam

AU - Celka, Roman

AU - Doberska, Agnieszka

AU - Czarny, Wojciech

AU - Podstawski, Robert

AU - Clark, Cain

AU - Yu, Fang

N1 - Copyright: © 2019 Gronek P et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. I

PY - 2019/12

Y1 - 2019/12

N2 - Although age is a dominant risk factor for Alzheimer’s disease (AD), epidemiological studies have shown that physical activity may significantly decrease age-related risks for AD, and indeed mitigate the impact in existing diagnosis. The aim of this study was to perform a narrative review on the preventative, and mitigating, effects of physical activity on AD onset, including genetic factors, mechanism of action and physical activity typology. In this article, we conducted a narrative review of the influence physical activity and exercise have on AD, utilising key terms related to AD, physical activity, mechanism and prevention, searching the online databases; Web of Science, PubMed and Google Scholar, and, subsequently, discuss possible mechanisms of this action. On the basis of this review, it is evident that physical activity and exercise may be incorporated in AD, notwithstanding, a greater number of high-quality randomised controlled trials are needed, moreover, physical activity typology must be acutely considered, primarily due to a dearth of research on the efficacy of physical activity types other than aerobic.

AB - Although age is a dominant risk factor for Alzheimer’s disease (AD), epidemiological studies have shown that physical activity may significantly decrease age-related risks for AD, and indeed mitigate the impact in existing diagnosis. The aim of this study was to perform a narrative review on the preventative, and mitigating, effects of physical activity on AD onset, including genetic factors, mechanism of action and physical activity typology. In this article, we conducted a narrative review of the influence physical activity and exercise have on AD, utilising key terms related to AD, physical activity, mechanism and prevention, searching the online databases; Web of Science, PubMed and Google Scholar, and, subsequently, discuss possible mechanisms of this action. On the basis of this review, it is evident that physical activity and exercise may be incorporated in AD, notwithstanding, a greater number of high-quality randomised controlled trials are needed, moreover, physical activity typology must be acutely considered, primarily due to a dearth of research on the efficacy of physical activity types other than aerobic.

KW - Alzheimer’s

KW - Prevention

KW - Physical Activity

KW - Exercise

KW - Aging

U2 - 10.14336/AD.2019.0226

DO - 10.14336/AD.2019.0226

M3 - Article

VL - 10

JO - Aging and Disease

JF - Aging and Disease

SN - 2152-5250

IS - 6

ER -