Physical Activity and Alzheimer’s Disease: A Narrative Review

Piotr Gronek, Štefan Balkó, Joanna Gronek, Adam Zając, Adam Maszczyk, Roman Celka, Agnieszka Doberska, Wojciech Czarny, Robert Podstawski, Cain Clark, Fang Yu

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    29 Citations (Scopus)
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    Although age is a dominant risk factor for Alzheimer’s disease (AD), epidemiological studies have shown that physical activity may significantly decrease age-related risks for AD, and indeed mitigate the impact in existing diagnosis. The aim of this study was to perform a narrative review on the preventative, and mitigating, effects of physical activity on AD onset, including genetic factors, mechanism of action and physical activity typology. In this article, we conducted a narrative review of the influence physical activity and exercise have on AD, utilising key terms related to AD, physical activity, mechanism and prevention, searching the online databases; Web of Science, PubMed and Google Scholar, and, subsequently, discuss possible mechanisms of this action. On the basis of this review, it is evident that physical activity and exercise may be incorporated in AD, notwithstanding, a greater number of high-quality randomised controlled trials are needed, moreover, physical activity typology must be acutely considered, primarily due to a dearth of research on the efficacy of physical activity types other than aerobic.
    Original languageEnglish
    Number of pages11
    JournalAging and Disease
    Issue number6
    Early online date12 Mar 2019
    Publication statusPublished - Dec 2019

    Bibliographical note

    Copyright: © 2019 Gronek P et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


    • Alzheimer’s
    • Prevention
    • Physical Activity
    • Exercise
    • Aging


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