Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life

D. C. P. Lee, S. A. Walker, A. J. Byrne, L. S. Gregory, James Buckley, A. Bush, S. O. Shaheen, S. Saglani, C. M. Lloyd

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    Abstract

    Background Current data concerning maternal paracetamol intake during pregnancy, or intake during infancy and risk of wheezing or asthma in childhood is inconclusive based on epidemiological studies. We have investigated whether there is a causal link between maternal paracetamol intake during pregnancy and lactation and the development of house dust mite (HDM) induced allergic airways disease (AAD) in offspring using a neonatal mouse model. Methods Pregnant mice were administered paracetamol or saline by oral gavage from the day of mating throughout pregnancy and/or lactation. Subsequently, their pups were exposed to intranasal HDM or saline from day 3 of life for up to 6 weeks. Assessments of airway hyper-responsiveness, inflammation and remodelling were made at weaning (3 weeks) and 6 weeks of age. Results Maternal paracetamol exposure either during pregnancy and/or lactation did not affect development of AAD in offspring at weaning or at 6 weeks. There were no effects of maternal paracetamol at any time point on airway remodelling or IgE levels. Conclusions Maternal paracetamol did not enhance HDM induced AAD in offspring. Our mechanistic data do not support the hypothesis that prenatal paracetamol exposure increases the risk of childhood asthma.
    Original languageEnglish
    Pages (from-to)528-536
    JournalThorax
    Volume70
    DOIs
    Publication statusPublished - 3 Apr 2015

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    Acetaminophen
    Pyroglyphidae
    Lactation
    Mothers
    Pregnancy
    Weaning
    Respiratory Hypersensitivity
    Asthma
    Airway Remodeling
    Maternal Exposure
    Respiratory Sounds
    Immunoglobulin E
    Epidemiologic Studies
    Inflammation

    Bibliographical note

    The full text is also available from: http://dx.doi.org/10.1136/thoraxjnl-2014-205280
    This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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    Lee, D. C. P., Walker, S. A., Byrne, A. J., Gregory, L. S., Buckley, J., Bush, A., ... Lloyd, C. M. (2015). Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life. Thorax, 70, 528-536. https://doi.org/10.1136/thoraxjnl-2014-205280

    Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life. / Lee, D. C. P.; Walker, S. A.; Byrne, A. J.; Gregory, L. S.; Buckley, James; Bush, A.; Shaheen, S. O.; Saglani, S.; Lloyd, C. M.

    In: Thorax, Vol. 70, 03.04.2015, p. 528-536.

    Research output: Contribution to journalArticle

    Lee, DCP, Walker, SA, Byrne, AJ, Gregory, LS, Buckley, J, Bush, A, Shaheen, SO, Saglani, S & Lloyd, CM 2015, 'Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life' Thorax, vol. 70, pp. 528-536. https://doi.org/10.1136/thoraxjnl-2014-205280
    Lee, D. C. P. ; Walker, S. A. ; Byrne, A. J. ; Gregory, L. S. ; Buckley, James ; Bush, A. ; Shaheen, S. O. ; Saglani, S. ; Lloyd, C. M. / Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life. In: Thorax. 2015 ; Vol. 70. pp. 528-536.
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    abstract = "Background Current data concerning maternal paracetamol intake during pregnancy, or intake during infancy and risk of wheezing or asthma in childhood is inconclusive based on epidemiological studies. We have investigated whether there is a causal link between maternal paracetamol intake during pregnancy and lactation and the development of house dust mite (HDM) induced allergic airways disease (AAD) in offspring using a neonatal mouse model. Methods Pregnant mice were administered paracetamol or saline by oral gavage from the day of mating throughout pregnancy and/or lactation. Subsequently, their pups were exposed to intranasal HDM or saline from day 3 of life for up to 6 weeks. Assessments of airway hyper-responsiveness, inflammation and remodelling were made at weaning (3 weeks) and 6 weeks of age. Results Maternal paracetamol exposure either during pregnancy and/or lactation did not affect development of AAD in offspring at weaning or at 6 weeks. There were no effects of maternal paracetamol at any time point on airway remodelling or IgE levels. Conclusions Maternal paracetamol did not enhance HDM induced AAD in offspring. Our mechanistic data do not support the hypothesis that prenatal paracetamol exposure increases the risk of childhood asthma.",
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    AU - Lee, D. C. P.

    AU - Walker, S. A.

    AU - Byrne, A. J.

    AU - Gregory, L. S.

    AU - Buckley, James

    AU - Bush, A.

    AU - Shaheen, S. O.

    AU - Saglani, S.

    AU - Lloyd, C. M.

    N1 - The full text is also available from: http://dx.doi.org/10.1136/thoraxjnl-2014-205280 This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

    PY - 2015/4/3

    Y1 - 2015/4/3

    N2 - Background Current data concerning maternal paracetamol intake during pregnancy, or intake during infancy and risk of wheezing or asthma in childhood is inconclusive based on epidemiological studies. We have investigated whether there is a causal link between maternal paracetamol intake during pregnancy and lactation and the development of house dust mite (HDM) induced allergic airways disease (AAD) in offspring using a neonatal mouse model. Methods Pregnant mice were administered paracetamol or saline by oral gavage from the day of mating throughout pregnancy and/or lactation. Subsequently, their pups were exposed to intranasal HDM or saline from day 3 of life for up to 6 weeks. Assessments of airway hyper-responsiveness, inflammation and remodelling were made at weaning (3 weeks) and 6 weeks of age. Results Maternal paracetamol exposure either during pregnancy and/or lactation did not affect development of AAD in offspring at weaning or at 6 weeks. There were no effects of maternal paracetamol at any time point on airway remodelling or IgE levels. Conclusions Maternal paracetamol did not enhance HDM induced AAD in offspring. Our mechanistic data do not support the hypothesis that prenatal paracetamol exposure increases the risk of childhood asthma.

    AB - Background Current data concerning maternal paracetamol intake during pregnancy, or intake during infancy and risk of wheezing or asthma in childhood is inconclusive based on epidemiological studies. We have investigated whether there is a causal link between maternal paracetamol intake during pregnancy and lactation and the development of house dust mite (HDM) induced allergic airways disease (AAD) in offspring using a neonatal mouse model. Methods Pregnant mice were administered paracetamol or saline by oral gavage from the day of mating throughout pregnancy and/or lactation. Subsequently, their pups were exposed to intranasal HDM or saline from day 3 of life for up to 6 weeks. Assessments of airway hyper-responsiveness, inflammation and remodelling were made at weaning (3 weeks) and 6 weeks of age. Results Maternal paracetamol exposure either during pregnancy and/or lactation did not affect development of AAD in offspring at weaning or at 6 weeks. There were no effects of maternal paracetamol at any time point on airway remodelling or IgE levels. Conclusions Maternal paracetamol did not enhance HDM induced AAD in offspring. Our mechanistic data do not support the hypothesis that prenatal paracetamol exposure increases the risk of childhood asthma.

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    JF - Thorax

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