Abstract
Objective
Pepino contains of flavonoid and phenol as antioxidant which can reduce total cholesterol. This research was aimed to study the effect of pepino extract on high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) in type 2 diabetic rats.
Method
The study was a randomized pre–posttest control group design. The subjects of this study were 20 male Wistar rats divided into 4 groups, they are control group, the group of pepino extract dosage 250 mg/kg BW, pepino extract dosage 500 mg/kg BW, and preventive group. Rats were induced diabetes with alloxan. Pepino extract was supplied for 2 weeks. Blood glucose level was evaluated on day 3 after alloxan injection, then HDL and LDL were monitored.
Results
The effect of pepino extract was not found significant to increase HDL or reduce LDL-C of diabetic rats at two different doses (p < 0.05). However, high dose of pepino extract (500 mg/kg BW) successfully inhibited the LDL increase in mice significantly.
Conclusion
Pepino extract can maintain HDL-C and LDL-C on alloxan induced diabetic rats. This food can potentially be a functional food that maintains the cholesterol profile.
Pepino contains of flavonoid and phenol as antioxidant which can reduce total cholesterol. This research was aimed to study the effect of pepino extract on high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) in type 2 diabetic rats.
Method
The study was a randomized pre–posttest control group design. The subjects of this study were 20 male Wistar rats divided into 4 groups, they are control group, the group of pepino extract dosage 250 mg/kg BW, pepino extract dosage 500 mg/kg BW, and preventive group. Rats were induced diabetes with alloxan. Pepino extract was supplied for 2 weeks. Blood glucose level was evaluated on day 3 after alloxan injection, then HDL and LDL were monitored.
Results
The effect of pepino extract was not found significant to increase HDL or reduce LDL-C of diabetic rats at two different doses (p < 0.05). However, high dose of pepino extract (500 mg/kg BW) successfully inhibited the LDL increase in mice significantly.
Conclusion
Pepino extract can maintain HDL-C and LDL-C on alloxan induced diabetic rats. This food can potentially be a functional food that maintains the cholesterol profile.
| Original language | English |
|---|---|
| Pages (from-to) | 163-166 |
| Number of pages | 4 |
| Journal | Enfermeria Clinica |
| Volume | 30 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 11 Jun 2020 |
| Externally published | Yes |
