Pepino extract (Solanum muricatum Ait.) on HDL and LDL in type 2 diabetic rats

Devintha Virani; Novia Nurul  Chaerunnisa; Iffah  Suarsi; Djunaidi M.  Dachlan; Andi Imam Arundhana  Thahir

doi:10.1016/j.enfcli.2019.10.061

Pepino extract (Solanum muricatum Ait.) on HDL and LDL in type 2 diabetic rats

Devintha Virani
, Novia Nurul Chaerunnisa
, Iffah Suarsi
, Djunaidi M. Dachlan
, Andi Imam Arundhana Thahir

Hasanuddin University
University of Sydney

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Objective
Pepino contains of flavonoid and phenol as antioxidant which can reduce total cholesterol. This research was aimed to study the effect of pepino extract on high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) in type 2 diabetic rats.

Method
The study was a randomized pre–posttest control group design. The subjects of this study were 20 male Wistar rats divided into 4 groups, they are control group, the group of pepino extract dosage 250 mg/kg BW, pepino extract dosage 500 mg/kg BW, and preventive group. Rats were induced diabetes with alloxan. Pepino extract was supplied for 2 weeks. Blood glucose level was evaluated on day 3 after alloxan injection, then HDL and LDL were monitored.

Results
The effect of pepino extract was not found significant to increase HDL or reduce LDL-C of diabetic rats at two different doses (p < 0.05). However, high dose of pepino extract (500 mg/kg BW) successfully inhibited the LDL increase in mice significantly.

Conclusion
Pepino extract can maintain HDL-C and LDL-C on alloxan induced diabetic rats. This food can potentially be a functional food that maintains the cholesterol profile.

Original language	English
Pages (from-to)	163-166
Number of pages	4
Journal	Enfermeria Clinica
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/j.enfcli.2019.10.061
Publication status	Published - 11 Jun 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.enfcli.2019.10.061

Cite this

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title = "Pepino extract (Solanum muricatum Ait.) on HDL and LDL in type 2 diabetic rats",

abstract = "Objective Pepino contains of flavonoid and phenol as antioxidant which can reduce total cholesterol. This research was aimed to study the effect of pepino extract on high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) in type 2 diabetic rats. Method The study was a randomized pre–posttest control group design. The subjects of this study were 20 male Wistar rats divided into 4 groups, they are control group, the group of pepino extract dosage 250 mg/kg BW, pepino extract dosage 500 mg/kg BW, and preventive group. Rats were induced diabetes with alloxan. Pepino extract was supplied for 2 weeks. Blood glucose level was evaluated on day 3 after alloxan injection, then HDL and LDL were monitored. Results The effect of pepino extract was not found significant to increase HDL or reduce LDL-C of diabetic rats at two different doses (p < 0.05). However, high dose of pepino extract (500 mg/kg BW) successfully inhibited the LDL increase in mice significantly. Conclusion Pepino extract can maintain HDL-C and LDL-C on alloxan induced diabetic rats. This food can potentially be a functional food that maintains the cholesterol profile.",

author = "Devintha Virani and Chaerunnisa, \{Novia Nurul\} and Iffah Suarsi and Dachlan, \{Djunaidi M.\} and Thahir, \{Andi Imam Arundhana\}",

year = "2020",

month = jun,

day = "11",

doi = "10.1016/j.enfcli.2019.10.061",

language = "English",

volume = "30",

pages = "163--166",

journal = "Enfermeria Clinica",

issn = "1130-8621",

publisher = "Elsevier Espana S.L.U",

number = "4",

}

TY - JOUR

T1 - Pepino extract (Solanum muricatum Ait.) on HDL and LDL in type 2 diabetic rats

AU - Virani, Devintha

AU - Chaerunnisa , Novia Nurul

AU - Suarsi, Iffah

AU - Dachlan, Djunaidi M.

AU - Thahir, Andi Imam Arundhana

PY - 2020/6/11

Y1 - 2020/6/11

N2 - Objective Pepino contains of flavonoid and phenol as antioxidant which can reduce total cholesterol. This research was aimed to study the effect of pepino extract on high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) in type 2 diabetic rats. Method The study was a randomized pre–posttest control group design. The subjects of this study were 20 male Wistar rats divided into 4 groups, they are control group, the group of pepino extract dosage 250 mg/kg BW, pepino extract dosage 500 mg/kg BW, and preventive group. Rats were induced diabetes with alloxan. Pepino extract was supplied for 2 weeks. Blood glucose level was evaluated on day 3 after alloxan injection, then HDL and LDL were monitored. Results The effect of pepino extract was not found significant to increase HDL or reduce LDL-C of diabetic rats at two different doses (p < 0.05). However, high dose of pepino extract (500 mg/kg BW) successfully inhibited the LDL increase in mice significantly. Conclusion Pepino extract can maintain HDL-C and LDL-C on alloxan induced diabetic rats. This food can potentially be a functional food that maintains the cholesterol profile.

AB - Objective Pepino contains of flavonoid and phenol as antioxidant which can reduce total cholesterol. This research was aimed to study the effect of pepino extract on high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) in type 2 diabetic rats. Method The study was a randomized pre–posttest control group design. The subjects of this study were 20 male Wistar rats divided into 4 groups, they are control group, the group of pepino extract dosage 250 mg/kg BW, pepino extract dosage 500 mg/kg BW, and preventive group. Rats were induced diabetes with alloxan. Pepino extract was supplied for 2 weeks. Blood glucose level was evaluated on day 3 after alloxan injection, then HDL and LDL were monitored. Results The effect of pepino extract was not found significant to increase HDL or reduce LDL-C of diabetic rats at two different doses (p < 0.05). However, high dose of pepino extract (500 mg/kg BW) successfully inhibited the LDL increase in mice significantly. Conclusion Pepino extract can maintain HDL-C and LDL-C on alloxan induced diabetic rats. This food can potentially be a functional food that maintains the cholesterol profile.

UR - https://www.scopus.com/pages/publications/85086686836

U2 - 10.1016/j.enfcli.2019.10.061

DO - 10.1016/j.enfcli.2019.10.061

M3 - Article

SN - 1130-8621

VL - 30

SP - 163

EP - 166

JO - Enfermeria Clinica

JF - Enfermeria Clinica

IS - 4

ER -

Pepino extract (Solanum muricatum Ait.) on HDL and LDL in type 2 diabetic rats

Abstract

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