Parametric and non-parametric gradient matching for network inference: a comparison

Leander Dony, Fei He, Michael P H Stumpf

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Reverse engineering of gene regulatory networks from time series gene-expression data is a challenging problem, not only because of the vast sets of candidate interactions but also due to the stochastic nature of gene expression. We limit our analysis to nonlinear differential equation based inference methods. In order to avoid the computational cost of large-scale simulations, a two-step Gaussian process interpolation based gradient matching approach has been proposed to solve differential equations approximately.

RESULTS: We apply a gradient matching inference approach to a large number of candidate models, including parametric differential equations or their corresponding non-parametric representations, we evaluate the network inference performance under various settings for different inference objectives. We use model averaging, based on the Bayesian Information Criterion (BIC), to combine the different inferences. The performance of different inference approaches is evaluated using area under the precision-recall curves.

CONCLUSIONS: We found that parametric methods can provide comparable, and often improved inference compared to non-parametric methods; the latter, however, require no kinetic information and are computationally more efficient.

Original languageEnglish
Article number52
Number of pages12
JournalBMC Bioinformatics
Volume20
Issue number1
DOIs
Publication statusPublished - 25 Jan 2019

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Differential equations
Gradient
Gene expression
Gene Expression
Reverse engineering
Gene Regulatory Networks
Time series
Interpolation
Genes
Costs and Cost Analysis
Kinetics
Differential equation
Model Averaging
Parametric equations
Limit Analysis
Bayesian Information Criterion
Reverse Engineering
Gene Regulatory Network
Nonparametric Methods
Gene Expression Data

Bibliographical note

© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

Keywords

  • Systems biology
  • Gradient matching
  • Gene regulation
  • Network inference

Cite this

Parametric and non-parametric gradient matching for network inference : a comparison. / Dony, Leander; He, Fei; Stumpf, Michael P H.

In: BMC Bioinformatics, Vol. 20, No. 1, 52, 25.01.2019.

Research output: Contribution to journalArticle

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