Palmitoylation-dependent protein sorting

Jennifer Greaves, Luke H Chamberlain

Research output: Contribution to journalReview article

167 Citations (Scopus)

Abstract

S-palmitoylation is a posttranslational modification that regulates membrane-protein interactions. However, palmitate is more than just a hydrophobic membrane anchor, as many different types of protein are palmitoylated, including transmembrane proteins. Indeed, there is now compelling evidence that palmitoylation plays a key role in regulating various aspects of protein sorting within the cell.

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalNature Cell Biology
Volume176
Issue number3
DOIs
Publication statusPublished - 29 Jan 2007
Externally publishedYes

Keywords

  • Animals
  • Humans
  • Palmitic Acids
  • Protein Processing, Post-Translational
  • Protein Transport
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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