Palmitoylation and the trafficking of peripheral membrane proteins

Luke H Chamberlain; Kimon Lemonidis; Maria Sanchez-Perez; Martin W Werno; Oforiwa A Gorleku; Jennifer Greaves

doi:10.1042/BST20120243

Palmitoylation and the trafficking of peripheral membrane proteins

Luke H Chamberlain, Kimon Lemonidis, Maria Sanchez-Perez, Martin W Werno, Oforiwa A Gorleku, Jennifer Greaves

University of Strathclyde

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Palmitoylation, the attachment of palmitate and other fatty acids on to cysteine residues, is a common post-translational modification of both integral and peripheral membrane proteins. Dynamic palmitoylation controls the intracellular distribution of peripheral membrane proteins by regulating membrane-cytosol exchange and/or by modifying the flux of the proteins through vesicular transport systems.

Original language	English
Pages (from-to)	62-66
Number of pages	5
Journal	Biochemical Society Transactions
Volume	41
Issue number	1
DOIs	https://doi.org/10.1042/BST20120243
Publication status	Published - 29 Jan 2013

Keywords

Cell Membrane
Golgi Apparatus
Lipoylation
Membrane Proteins
Palmitic Acid
Protein Transport
Subcellular Fractions
Synaptosomal-Associated Protein 25
ras Proteins
Journal Article
Research Support, Non-U.S. Gov't

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abstract = "Palmitoylation, the attachment of palmitate and other fatty acids on to cysteine residues, is a common post-translational modification of both integral and peripheral membrane proteins. Dynamic palmitoylation controls the intracellular distribution of peripheral membrane proteins by regulating membrane-cytosol exchange and/or by modifying the flux of the proteins through vesicular transport systems.",

keywords = "Cell Membrane, Golgi Apparatus, Lipoylation, Membrane Proteins, Palmitic Acid, Protein Transport, Subcellular Fractions, Synaptosomal-Associated Protein 25, ras Proteins, Journal Article, Research Support, Non-U.S. Gov't",

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AU - Chamberlain, Luke H

AU - Lemonidis, Kimon

AU - Sanchez-Perez, Maria

AU - Werno, Martin W

AU - Gorleku, Oforiwa A

AU - Greaves, Jennifer

PY - 2013/1/29

Y1 - 2013/1/29

N2 - Palmitoylation, the attachment of palmitate and other fatty acids on to cysteine residues, is a common post-translational modification of both integral and peripheral membrane proteins. Dynamic palmitoylation controls the intracellular distribution of peripheral membrane proteins by regulating membrane-cytosol exchange and/or by modifying the flux of the proteins through vesicular transport systems.

AB - Palmitoylation, the attachment of palmitate and other fatty acids on to cysteine residues, is a common post-translational modification of both integral and peripheral membrane proteins. Dynamic palmitoylation controls the intracellular distribution of peripheral membrane proteins by regulating membrane-cytosol exchange and/or by modifying the flux of the proteins through vesicular transport systems.

KW - Cell Membrane

KW - Golgi Apparatus

KW - Lipoylation

KW - Membrane Proteins

KW - Palmitic Acid

KW - Protein Transport

KW - Subcellular Fractions

KW - Synaptosomal-Associated Protein 25

KW - ras Proteins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1042/BST20120243

DO - 10.1042/BST20120243

M3 - Article

C2 - 23356259

SN - 0300-5127

VL - 41

SP - 62

EP - 66

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 1

ER -

Palmitoylation and the trafficking of peripheral membrane proteins

Abstract

Keywords

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