On the role of CO2 laser treatment in the human serum albumin and human plasma fibronectin adsorption on zirconia (MGO-PSZ) bioceramic surface

Liang Hao, J. Lawrence

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


The nature of the surface strongly influences the composition and recognizability of the adsorbed protein layer, which in turn affects the subsequent cellular interactions. Thus, to understand the biological response to a material, especially in vitro, one must fully understand the nature of the adsorbed protein film that forms on the material. This study investigates the fundamental interactions between the human serum albumin (no-cell adhesive) and human plasma fibronectin and bioinert ceramic following CO2 laser treatment. The analysis of the albumin and fibronectin adsorption was conducted on the untreated and CO2 laser-modified magnesia partially stabilized zirconia (MgO-PSZ) bioceramic using an ellipsometry. It was found that the adsorptions of albumin and fibronectin were influenced by the surface properties. The albumin adsorption was affected by the surface roughness and wettability characteristics of the MgO-PSZ and decreased with these properties, while the fibronectin adsorption was increased with wettability characteristics and predominantly governed by this property. Moreover, the considerable change in the polar component of surface energy, γsv p, and its effect on protein adsorption implied that the albumin and fibronectin adsorption on the MgO-PSZ surfaces was probably due to the polar and chemical interactions. The value of this work is to provide a novel technique and useful information for manipulating protein adsorption and thereof cellular interactions.

Original languageEnglish
Pages (from-to)748-756
Number of pages9
JournalJournal of Biomedical Materials Research - Part A
Issue number4
Publication statusPublished - 4 May 2004
Externally publishedYes


  • CO laser
  • Human plasma fibronectin
  • Human serum albumin
  • Magnesia partially stabilized zirconia (MgO-PSZ)
  • Protein adsorption
  • Wettability characteristics

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys


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