Abstract
Subjects/Methods: We used zebrafish (Danio rerio) in a factorial design to compare energy metabolism, locomotor capacity, muscle isometric force and work-loop power output, and myosin heavy chain composition between lean fish, diet-induced obese fish, and fish that were obese and then returned to lean body mass following diet restriction.
Results: Obesity increased resting metabolic rates (p < 0.001) and decreased maximal metabolic rates (p = 0.030), but these changes were reversible by weight-loss, and were not associated with changes in muscle citrate synthase activity. In contrast, obesity-induced decreases in locomotor performance (p = 0.0034), and isolated muscle isometric stress (p = 0.01), work loop power output (p < 0.001), and relaxation rates (p = 0.012) were not reversed by weight loss. Similarly, obesity-induced decreases in concentrations of fast and slow myosin heavy chains, and a shift towards fast myosin heavy chains were not reversed by weight loss.
Conclusion: Obesity-induced changes in locomotor performance and muscle contractile function were not reversible by weight loss. These results show that weight loss alone may not be a sufficient intervention.
| Original language | English |
|---|---|
| Pages (from-to) | 1271-1278 |
| Journal | International Journal of Obesity |
| Volume | 41 |
| Issue number | 8 |
| Early online date | 24 Mar 2017 |
| DOIs | |
| Publication status | Published - Aug 2017 |
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Bibliographical note
The full text is currently unavailable on the repository.Cite this
Obesity-induced decreases in muscle performance are not reversible by weight loss. / Seebacher, Frank; Tallis, Jason; McShea, Kate; James, Rob.
In: International Journal of Obesity, Vol. 41, No. 8, 08.2017, p. 1271-1278.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Obesity-induced decreases in muscle performance are not reversible by weight loss
AU - Seebacher, Frank
AU - Tallis, Jason
AU - McShea, Kate
AU - James, Rob
N1 - The full text is currently unavailable on the repository.
PY - 2017/8
Y1 - 2017/8
N2 - Background/Objectives: Obesity can affect muscle phenotypes, and may thereby constrain movement and energy expenditure. Weight loss is a common and intuitive intervention for obesity, but it is not known whether the effects of obesity on muscle function are reversible by weight loss. Here we tested whether obesity-induced changes in muscle metabolic and contractile phenotypes are reversible by weight loss.Subjects/Methods: We used zebrafish (Danio rerio) in a factorial design to compare energy metabolism, locomotor capacity, muscle isometric force and work-loop power output, and myosin heavy chain composition between lean fish, diet-induced obese fish, and fish that were obese and then returned to lean body mass following diet restriction.Results: Obesity increased resting metabolic rates (p < 0.001) and decreased maximal metabolic rates (p = 0.030), but these changes were reversible by weight-loss, and were not associated with changes in muscle citrate synthase activity. In contrast, obesity-induced decreases in locomotor performance (p = 0.0034), and isolated muscle isometric stress (p = 0.01), work loop power output (p < 0.001), and relaxation rates (p = 0.012) were not reversed by weight loss. Similarly, obesity-induced decreases in concentrations of fast and slow myosin heavy chains, and a shift towards fast myosin heavy chains were not reversed by weight loss.Conclusion: Obesity-induced changes in locomotor performance and muscle contractile function were not reversible by weight loss. These results show that weight loss alone may not be a sufficient intervention.
AB - Background/Objectives: Obesity can affect muscle phenotypes, and may thereby constrain movement and energy expenditure. Weight loss is a common and intuitive intervention for obesity, but it is not known whether the effects of obesity on muscle function are reversible by weight loss. Here we tested whether obesity-induced changes in muscle metabolic and contractile phenotypes are reversible by weight loss.Subjects/Methods: We used zebrafish (Danio rerio) in a factorial design to compare energy metabolism, locomotor capacity, muscle isometric force and work-loop power output, and myosin heavy chain composition between lean fish, diet-induced obese fish, and fish that were obese and then returned to lean body mass following diet restriction.Results: Obesity increased resting metabolic rates (p < 0.001) and decreased maximal metabolic rates (p = 0.030), but these changes were reversible by weight-loss, and were not associated with changes in muscle citrate synthase activity. In contrast, obesity-induced decreases in locomotor performance (p = 0.0034), and isolated muscle isometric stress (p = 0.01), work loop power output (p < 0.001), and relaxation rates (p = 0.012) were not reversed by weight loss. Similarly, obesity-induced decreases in concentrations of fast and slow myosin heavy chains, and a shift towards fast myosin heavy chains were not reversed by weight loss.Conclusion: Obesity-induced changes in locomotor performance and muscle contractile function were not reversible by weight loss. These results show that weight loss alone may not be a sufficient intervention.
U2 - 10.1038/ijo.2017.81
DO - 10.1038/ijo.2017.81
M3 - Article
VL - 41
SP - 1271
EP - 1278
JO - International Journal of Obesity
JF - International Journal of Obesity
SN - 0307-0565
IS - 8
ER -