Obesity-induced decreases in muscle performance are not reversible by weight loss

Frank Seebacher, Jason Tallis, Kate McShea, Rob James

Research output: Contribution to journalArticle

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32 Downloads (Pure)

Abstract

Background/Objectives: Obesity can affect muscle phenotypes, and may thereby constrain movement and energy expenditure. Weight loss is a common and intuitive intervention for obesity, but it is not known whether the effects of obesity on muscle function are reversible by weight loss. Here we tested whether obesity-induced changes in muscle metabolic and contractile phenotypes are reversible by weight loss.
Subjects/Methods: We used zebrafish (Danio rerio) in a factorial design to compare energy metabolism, locomotor capacity, muscle isometric force and work-loop power output, and myosin heavy chain composition between lean fish, diet-induced obese fish, and fish that were obese and then returned to lean body mass following diet restriction.
Results: Obesity increased resting metabolic rates (p < 0.001) and decreased maximal metabolic rates (p = 0.030), but these changes were reversible by weight-loss, and were not associated with changes in muscle citrate synthase activity. In contrast, obesity-induced decreases in locomotor performance (p = 0.0034), and isolated muscle isometric stress (p = 0.01), work loop power output (p < 0.001), and relaxation rates (p = 0.012) were not reversed by weight loss. Similarly, obesity-induced decreases in concentrations of fast and slow myosin heavy chains, and a shift towards fast myosin heavy chains were not reversed by weight loss.
Conclusion: Obesity-induced changes in locomotor performance and muscle contractile function were not reversible by weight loss. These results show that weight loss alone may not be a sufficient intervention.
Original languageEnglish
Pages (from-to)1271-1278
JournalInternational Journal of Obesity
Volume41
Issue number8
Early online date24 Mar 2017
DOIs
Publication statusPublished - Aug 2017

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Weight Loss
Obesity
Muscles
Myosin Heavy Chains
Fishes
Zebrafish
Energy Metabolism
Diet
Phenotype
Basal Metabolism
Citrate (si)-Synthase

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Obesity-induced decreases in muscle performance are not reversible by weight loss. / Seebacher, Frank; Tallis, Jason; McShea, Kate; James, Rob.

In: International Journal of Obesity, Vol. 41, No. 8, 08.2017, p. 1271-1278.

Research output: Contribution to journalArticle

Seebacher, Frank ; Tallis, Jason ; McShea, Kate ; James, Rob. / Obesity-induced decreases in muscle performance are not reversible by weight loss. In: International Journal of Obesity. 2017 ; Vol. 41, No. 8. pp. 1271-1278.
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