Nucleotide modifications in messenger RNA and their role in development and disease

V. Dezi, C. Ivanov, Irmgard U. Haussmann, M. Soller

    Research output: Contribution to journalArticlepeer-review

    31 Citations (Scopus)

    Abstract

    Modified nucleotides in messenger RNA (mRNA) have been discovered over 40 years ago, but until recently little was known about which transcripts contain them and what their function is. High-throughput sequencing approaches revealed a dynamic landscape of the ‘Epitranscriptome’ for many mRNA modifications in various organisms from yeast to humans. Meanwhile, also many genes encoding mRNA-modifying enzymes and auxiliary proteins have been identified yielding functional insights by reverse genetics into their role in development and disease.
    Original languageEnglish
    Pages (from-to)1385-1393
    JournalBiochemical Society Transactions
    Volume44
    Issue number5
    DOIs
    Publication statusPublished - 19 Oct 2016

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