Nucleotide modifications in messenger RNA and their role in development and disease

V. Dezi; C. Ivanov; Irmgard U. Haussmann; M. Soller

doi:10.1042/BST20160110

Nucleotide modifications in messenger RNA and their role in development and disease

V. Dezi, C. Ivanov, Irmgard U. Haussmann, M. Soller

School of Life Sciences

Research output: Contribution to journal › Article

19 Citations (Scopus)

Abstract

Modified nucleotides in messenger RNA (mRNA) have been discovered over 40 years ago, but until recently little was known about which transcripts contain them and what their function is. High-throughput sequencing approaches revealed a dynamic landscape of the ‘Epitranscriptome’ for many mRNA modifications in various organisms from yeast to humans. Meanwhile, also many genes encoding mRNA-modifying enzymes and auxiliary proteins have been identified yielding functional insights by reverse genetics into their role in development and disease.

Original language	English
Pages (from-to)	1385-1393
Journal	Biochemical Society Transactions
Volume	44
Issue number	5
DOIs	https://doi.org/10.1042/BST20160110
Publication status	Published - 19 Oct 2016

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10.1042/BST20160110

https://research.birmingham.ac.uk/portal/en/publications/nucleotide-modifications-in-messenger-rna-and-their-role-in-development-and-disease(56eff18c-4eb9-48b8-906a-380f85e95908).html

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