NT-proBNP is a weak indicator of cardiac function and haemodynamic response to exercise in chronic heart failure

Milos Parovic, Nduka C Okwose, Kristian Bailey, Lazar Velicki, Zlatko Fras, Petar M Seferovic, Guy A MacGowan, Djordje G Jakovljevic

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
18 Downloads (Pure)


AIMS: N-terminal prohormone of brain natriuretic peptide (NT-proBNP) plays an important role in diagnosis and management of heart failure. The aim of the present study was to assess haemodynamic response to exercise and to evaluate the relationship between NT-proBNP, cardiac function, and exercise tolerance in chronic heart failure.

METHODS AND RESULTS: A single-centre, cross-sectional pilot study recruited 17 patients with chronic heart failure with reduced left ventricular ejection fraction (age 67 ± 7 years) and 20 healthy volunteers (age 65 ± 12 years). The NT-proBNP was measured in the heart failure group. All participants completed maximal graded cardiopulmonary exercise stress testing coupled with gas exchange (using metabolic analyser for determination of exercise tolerance, i.e. peak O2 consumption) and continuous haemodynamic measurements (i.e. cardiac output and cardiac power output) using non-invasive bioreactance technology. Heart failure patients demonstrated significantly lower peak exercise cardiac function and exercise tolerance than healthy controls, i.e. cardiac power output (5.0 ± 2.0 vs. 3.2 ± 1.2 W, P < 0.01), cardiac output (18.2 ± 6.3 vs. 13.5 ± 4.0 L/min, P < 0.01), heart rate (148 ± 23.7 vs. 111 ± 20.9 beats/min, P < 0.01), and oxygen consumption (24.3 ± 9.5 vs. 16.8 ± 3.8 mL/kg/min, P < 0.01). There was no significant relationship between NT-proBNP and cardiac function at rest, i.e. cardiac power output (r = -0.28, P = 0.28), cardiac output (r = -0.18, P = 0.50), and oxygen consumption (r = -0.18, P = 0.50), or peak exercise, i.e. cardiac power output (r = 0.18, P = 0.49), cardiac output (r = 0.13, P = 0.63), and oxygen consumption (r = -0.05, P = 0.84).

CONCLUSIONS: Lack of a significant and strong relationship between the NT-proBNP and measures of cardiac function and exercise tolerance may suggest that natriuretic peptides should be considered with caution in interpretation of the severity of cardiac dysfunction and functional capacity in chronic heart failure.

Original languageEnglish
Pages (from-to)449-454
Number of pages6
JournalESC Heart Failure
Issue number2
Early online date19 Feb 2019
Publication statusPublished - Apr 2019
Externally publishedYes

Bibliographical note

© 2019 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.


  • Aged
  • Biomarkers/blood
  • Cross-Sectional Studies
  • Exercise Test
  • Exercise Tolerance/physiology
  • Female
  • Heart Failure/blood
  • Hemodynamics
  • Humans
  • Male
  • Natriuretic Peptide, Brain/blood
  • Peptide Fragments/blood
  • Pilot Projects
  • Protein Precursors
  • Stroke Volume/physiology
  • Ventricular Function, Left/physiology


Dive into the research topics of 'NT-proBNP is a weak indicator of cardiac function and haemodynamic response to exercise in chronic heart failure'. Together they form a unique fingerprint.

Cite this