Non-Linear Dynamical Analysis of Resting Tremor for Demand-Driven Deep Brain Stimulation

Carmen Camara, Narayan Subramaniyan, Kevin Warwick, Lauri Parkkonen, Tipu Aziz, Ernesto Pereda

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Abstract

Parkinson’s Disease (PD) is currently the second most common neurodegenerative disease. One of the most characteristic symptoms of PD is resting tremor. Local Field Potentials (LFPs) have been widely studied to investigate deviations from the typical patterns of healthy brain activity. However, the inherent dynamics of the Sub-Thalamic Nucleus (STN) LFPs and their spatiotemporal dynamics have not been well characterized. In this work, we study the non-linear dynamical behaviour of STN-LFPs of Parkinsonian patients using ε -recurrence networks. RNs are a non-linear analysis tool that encodes the geometric information of the underlying system, which can be characterised (for example, using graph theoretical measures) to extract information on the geometric properties of the attractor. Results show that the activity of the STN becomes more non-linear during the tremor episodes and that ε -recurrence network analysis is a suitable method to distinguish the transitions between movement conditions, anticipating the onset of the tremor, with the potential for application in a demand-driven deep brain stimulation system.
Original languageEnglish
Article number2507
Number of pages16
JournalSensors
Volume19
Issue number11
Early online date31 May 2019
DOIs
Publication statusPublished - 31 May 2019

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tremors
Thalamic Nuclei
Deep Brain Stimulation
Tremor
potential fields
stimulation
Parkinson disease
brain
Brain
Neurodegenerative diseases
nuclei
Parkinson Disease
Nonlinear analysis
Electric network analysis
network analysis
Recurrence
Information Systems
Neurodegenerative Diseases
deviation

Bibliographical note

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Keywords

  • Deep Brain Stimulation (DBS)
  • Local Field Potentials (LFPs)
  • Nonlinear dynamics
  • Parkinson’s Disease (PD)
  • Recurrence Networks (RNs)
  • Support Vector Machine (SVM)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Biochemistry
  • Instrumentation
  • Electrical and Electronic Engineering

Cite this

Camara, C., Subramaniyan, N., Warwick, K., Parkkonen, L., Aziz, T., & Pereda, E. (2019). Non-Linear Dynamical Analysis of Resting Tremor for Demand-Driven Deep Brain Stimulation. Sensors, 19(11), [2507]. https://doi.org/10.3390/s19112507

Non-Linear Dynamical Analysis of Resting Tremor for Demand-Driven Deep Brain Stimulation. / Camara, Carmen; Subramaniyan, Narayan; Warwick, Kevin; Parkkonen, Lauri; Aziz, Tipu; Pereda, Ernesto.

In: Sensors, Vol. 19, No. 11, 2507, 31.05.2019.

Research output: Contribution to journalArticle

Camara, C, Subramaniyan, N, Warwick, K, Parkkonen, L, Aziz, T & Pereda, E 2019, 'Non-Linear Dynamical Analysis of Resting Tremor for Demand-Driven Deep Brain Stimulation' Sensors, vol. 19, no. 11, 2507. https://doi.org/10.3390/s19112507
Camara, Carmen ; Subramaniyan, Narayan ; Warwick, Kevin ; Parkkonen, Lauri ; Aziz, Tipu ; Pereda, Ernesto. / Non-Linear Dynamical Analysis of Resting Tremor for Demand-Driven Deep Brain Stimulation. In: Sensors. 2019 ; Vol. 19, No. 11.
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