No association between coding polymorphism within Exon 4 of the human surfactant protein B gene and pulmonary function in healthy men

Stuart M Raleigh, Benjamin M Davies, David Cleal, William J Ribbans

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The coding polymorphism (rs1130866) within the surfactant protein B gene is known to associate with certain respiratory abnormalities. We investigated, using spirometry and fluorescence-based PCR, whether this variant influenced pulmonary function in healthy, nonsmoking men. We found no association of pulmonary function with genotype at the rs1130866 locus.

Original languageEnglish
Pages (from-to)199-202
Number of pages4
JournalJournal of Physiological Sciences
Volume57
Issue number3
DOIs
Publication statusPublished - Jun 2007
Externally publishedYes

Keywords

  • Adult
  • Cohort Studies
  • Exons
  • Forced Expiratory Volume
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Polymorphism, Single Nucleotide
  • Pulmonary Surfactant-Associated Protein B
  • Pulmonary Surfactants
  • Pulmonary Ventilation
  • Vital Capacity
  • Journal Article

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