No association between coding polymorphism within Exon 4 of the human surfactant protein B gene and pulmonary function in healthy men

Stuart M Raleigh; Benjamin M Davies; David Cleal; William J Ribbans

doi:10.2170/physiolsci.SC002607

No association between coding polymorphism within Exon 4 of the human surfactant protein B gene and pulmonary function in healthy men

Stuart M Raleigh, Benjamin M Davies, David Cleal, William J Ribbans

University of Northampton

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The coding polymorphism (rs1130866) within the surfactant protein B gene is known to associate with certain respiratory abnormalities. We investigated, using spirometry and fluorescence-based PCR, whether this variant influenced pulmonary function in healthy, nonsmoking men. We found no association of pulmonary function with genotype at the rs1130866 locus.

Original language	English
Pages (from-to)	199-202
Number of pages	4
Journal	Journal of Physiological Sciences
Volume	57
Issue number	3
DOIs	https://doi.org/10.2170/physiolsci.SC002607
Publication status	Published - Jun 2007
Externally published	Yes

Keywords

Adult
Cohort Studies
Exons
Forced Expiratory Volume
Gene Frequency
Genetic Predisposition to Disease
Humans
Male
Polymorphism, Single Nucleotide
Pulmonary Surfactant-Associated Protein B
Pulmonary Surfactants
Pulmonary Ventilation
Vital Capacity
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2170/physiolsci.SC002607

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abstract = "The coding polymorphism (rs1130866) within the surfactant protein B gene is known to associate with certain respiratory abnormalities. We investigated, using spirometry and fluorescence-based PCR, whether this variant influenced pulmonary function in healthy, nonsmoking men. We found no association of pulmonary function with genotype at the rs1130866 locus.",

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T1 - No association between coding polymorphism within Exon 4 of the human surfactant protein B gene and pulmonary function in healthy men

AU - Raleigh, Stuart M

AU - Davies, Benjamin M

AU - Cleal, David

AU - Ribbans, William J

PY - 2007/6

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AB - The coding polymorphism (rs1130866) within the surfactant protein B gene is known to associate with certain respiratory abnormalities. We investigated, using spirometry and fluorescence-based PCR, whether this variant influenced pulmonary function in healthy, nonsmoking men. We found no association of pulmonary function with genotype at the rs1130866 locus.

KW - Adult

KW - Cohort Studies

KW - Exons

KW - Forced Expiratory Volume

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Pulmonary Surfactant-Associated Protein B

KW - Pulmonary Surfactants

KW - Pulmonary Ventilation

KW - Vital Capacity

KW - Journal Article

U2 - 10.2170/physiolsci.SC002607

DO - 10.2170/physiolsci.SC002607

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VL - 57

SP - 199

EP - 202

JO - Journal of Physiological Sciences

JF - Journal of Physiological Sciences

IS - 3

ER -

No association between coding polymorphism within Exon 4 of the human surfactant protein B gene and pulmonary function in healthy men

Abstract

Keywords

UN SDGs

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