New links between S-acylation and cancer

Jennifer Greaves, Luke H Chamberlain

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

S-acylation (also known as palmitoylation) is a major post-translational protein modification in all eukaryotic cells, involving the attachment of fatty acids onto cysteine residues. A variety of structural and signalling proteins are modified in this way, affecting their stability, membrane association and intracellular targeting. The enzymes that mediate S-acylation are encoded by genes belonging to the large (> 20 genes) ZDHHC family. The importance of these enzymes for normal physiological function is highlighted by their links to a diverse range of disease states, including neurological disorders, such as Huntington's disease, schizophrenia and intellectual disability, and diabetes and cancer. The recent study by Yeste-Velasco et al published in the Journal of Pathology highlights a novel tumour suppressor function for the zDHHC family: expression of zDHHC14 is decreased in testicular germ cell tumours, prostate cancer and a variety of other cancer types. This important finding further emphasizes the emerging clinical significance of the zDHHC family of S-acylation enzymes.

Original languageEnglish
Pages (from-to)4-6
Number of pages3
JournalJournal of Pathology
Volume233
Issue number1
DOIs
Publication statusPublished - 12 Apr 2014
Externally publishedYes

Keywords

  • Acyltransferases
  • Animals
  • Genes, Tumor Suppressor
  • Humans
  • Male
  • Neoplasms, Germ Cell and Embryonal
  • Prostatic Neoplasms
  • Testicular Neoplasms
  • Comment
  • Journal Article
  • Research Support, Non-U.S. Gov't

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