Neuroimaging Biomarkers for Diagnosing Cerebral Small Vessel Disease

Aiza Iqbal; Nicole Yan Chee Lau; Carlin Chang; Gary Tse; Haipeng Liu; Fatima Faraz; Jeremy Man Ho Hui

doi:10.1201/9781003481621-5

Neuroimaging Biomarkers for Diagnosing Cerebral Small Vessel Disease

Aiza Iqbal
, Nicole Yan Chee Lau
, Carlin Chang
, Gary Tse
, Haipeng Liu
, Fatima Faraz
, Jeremy Man Ho Hui

Rawalpindi Medical University
The University of Hong Kong
Hong Kong Metropolitan University
Chinese University of Hong Kong
The Second Hospital of Tianjin Medical University
Powerhealth Research Institute

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Cerebral small vessel disease (CSVD) is a term that relates to a large number of pathological changes in the microvessels of the brain. With advances in technology in terms of hardware, imaging processing algorithms, and data science, new biomarkers associated with CSVD have been extracted from neuroimaging data. This chapter provides an overview of neuroimaging modalities for CSVD, including computed tomography, magnetic resonance imaging (MRI), diffusion MRI, iron imaging, myelin imaging, cerebrovascular reactivity imaging, and vessel wall imaging. It also discusses existing and emerging or novel biomarkers from the different investigation modalities. We evaluate the diagnostic values of these neuroimaging biomarkers from a clinical perspective and summarize the limitations as well as future directions.

Original language	English
Title of host publication	Cutting-Edge Diagnostic Technologies in Cardiovascular Diseases
Subtitle of host publication	Towards Data-Driven Smart Healthcare
Editors	Haipeng Liu, Gary Tse
Publisher	CRC Press, Taylor & Francis Group
Chapter	5
Pages	76-91
Number of pages	16
Edition	1
ISBN (Electronic)	9781003481621
ISBN (Print)	9781032771694
DOIs	https://doi.org/10.1201/9781003481621-5
Publication status	Published - 23 Jun 2025

Bibliographical note

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

Keywords

Cerebral small vessel disease
neuroimaging
biomarkers
artificial intelligence

Access to Document

10.1201/9781003481621-5

Cite this

Iqbal, A., Lau, N. Y. C., Chang, C., Tse, G., Liu, H., Faraz, F., & Hui, J. M. H. (2025). Neuroimaging Biomarkers for Diagnosing Cerebral Small Vessel Disease. In H. Liu, & G. Tse (Eds.), Cutting-Edge Diagnostic Technologies in Cardiovascular Diseases: Towards Data-Driven Smart Healthcare (1 ed., pp. 76-91). CRC Press, Taylor & Francis Group. https://doi.org/10.1201/9781003481621-5

Neuroimaging Biomarkers for Diagnosing Cerebral Small Vessel Disease. / Iqbal, Aiza; Lau, Nicole Yan Chee; Chang, Carlin et al.
Cutting-Edge Diagnostic Technologies in Cardiovascular Diseases: Towards Data-Driven Smart Healthcare. ed. / Haipeng Liu; Gary Tse. 1. ed. CRC Press, Taylor & Francis Group, 2025. p. 76-91.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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abstract = "Cerebral small vessel disease (CSVD) is a term that relates to a large number of pathological changes in the microvessels of the brain. With advances in technology in terms of hardware, imaging processing algorithms, and data science, new biomarkers associated with CSVD have been extracted from neuroimaging data. This chapter provides an overview of neuroimaging modalities for CSVD, including computed tomography, magnetic resonance imaging (MRI), diffusion MRI, iron imaging, myelin imaging, cerebrovascular reactivity imaging, and vessel wall imaging. It also discusses existing and emerging or novel biomarkers from the different investigation modalities. We evaluate the diagnostic values of these neuroimaging biomarkers from a clinical perspective and summarize the limitations as well as future directions.",

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AU - Faraz, Fatima

AU - Hui, Jeremy Man Ho

N1 - Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

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N2 - Cerebral small vessel disease (CSVD) is a term that relates to a large number of pathological changes in the microvessels of the brain. With advances in technology in terms of hardware, imaging processing algorithms, and data science, new biomarkers associated with CSVD have been extracted from neuroimaging data. This chapter provides an overview of neuroimaging modalities for CSVD, including computed tomography, magnetic resonance imaging (MRI), diffusion MRI, iron imaging, myelin imaging, cerebrovascular reactivity imaging, and vessel wall imaging. It also discusses existing and emerging or novel biomarkers from the different investigation modalities. We evaluate the diagnostic values of these neuroimaging biomarkers from a clinical perspective and summarize the limitations as well as future directions.

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Neuroimaging Biomarkers for Diagnosing Cerebral Small Vessel Disease

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