Muscarinic receptor subtypes and the selectivity of agonists and antagonists

N. J.M. Birdsall; C. A.M. Curtis; P. Eveleigh; E. C. Hulme; E. K. Pedder; D. Poyner; M. Wheatley

doi:10.1159/000138503

Muscarinic receptor subtypes and the selectivity of agonists and antagonists

N. J.M. Birdsall, C. A.M. Curtis, P. Eveleigh, E. C. Hulme, E. K. Pedder, D. Poyner, M. Wheatley

MRC National Institute for Medical Research

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

Receptors may be grouped into superfamilies, according to their mechanism. Muscarinic receptors belong to one such superfamily, that of the G-protein coupled receptors. Subtypes of muscarinic receptors may be defined according to their primary amino acid sequence, their mechanism and their pharmacology. However, there is as yet no consistent scheme to explain the pharmacology and function of each molecular subtype. The pharmacological tools which distinguish between muscarinic receptor subtypes are described and the emerging evidence for the location of the ligand binding site is discussed.

Original language	English
Pages (from-to)	22-31
Number of pages	10
Journal	Pharmacology
Volume	37
Issue number	Suppl. 1
DOIs	https://doi.org/10.1159/000138503
Publication status	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Pharmacology

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abstract = "Receptors may be grouped into superfamilies, according to their mechanism. Muscarinic receptors belong to one such superfamily, that of the G-protein coupled receptors. Subtypes of muscarinic receptors may be defined according to their primary amino acid sequence, their mechanism and their pharmacology. However, there is as yet no consistent scheme to explain the pharmacology and function of each molecular subtype. The pharmacological tools which distinguish between muscarinic receptor subtypes are described and the emerging evidence for the location of the ligand binding site is discussed.",

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AU - Birdsall, N. J.M.

AU - Curtis, C. A.M.

AU - Eveleigh, P.

AU - Hulme, E. C.

AU - Pedder, E. K.

AU - Poyner, D.

AU - Wheatley, M.

PY - 1988

Y1 - 1988

N2 - Receptors may be grouped into superfamilies, according to their mechanism. Muscarinic receptors belong to one such superfamily, that of the G-protein coupled receptors. Subtypes of muscarinic receptors may be defined according to their primary amino acid sequence, their mechanism and their pharmacology. However, there is as yet no consistent scheme to explain the pharmacology and function of each molecular subtype. The pharmacological tools which distinguish between muscarinic receptor subtypes are described and the emerging evidence for the location of the ligand binding site is discussed.

AB - Receptors may be grouped into superfamilies, according to their mechanism. Muscarinic receptors belong to one such superfamily, that of the G-protein coupled receptors. Subtypes of muscarinic receptors may be defined according to their primary amino acid sequence, their mechanism and their pharmacology. However, there is as yet no consistent scheme to explain the pharmacology and function of each molecular subtype. The pharmacological tools which distinguish between muscarinic receptor subtypes are described and the emerging evidence for the location of the ligand binding site is discussed.

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U2 - 10.1159/000138503

DO - 10.1159/000138503

M3 - Review article

C2 - 2467316

AN - SCOPUS:0023727797

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JO - Pharmacology

JF - Pharmacology

IS - Suppl. 1

ER -

Muscarinic receptor subtypes and the selectivity of agonists and antagonists

Abstract

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