Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise.

Adam Thomas, Andrea Dennis, Nancy Rawlings, Charlotte Stagg, Lucy Matthews, Martyn Morris, Shannon Kolind, Sean Foxley, Mark Jenkinson, Thomas Nichols, Helen Dawes, Peter Bandettini, Heidi Johansen-Berg

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Abstract

The hippocampus has been shown to demonstrate a remarkable degree of plasticity in response to a variety of tasks and experiences. For example, the size of the human hippocampus has been shown to increase in response to aerobic exercise. However, it is currently unknown what underlies these changes. Here we scanned sedentary, young to middle-aged human adults before and after a six-week exercise intervention using nine different neuroimaging measures of brain structure, vasculature, and diffusion. We then tested two different hypotheses regarding the nature of the underlying changes in the tissue. Surprisingly, we found no evidence of a vascular change as has been previously reported. Rather, the pattern of changes is better explained by an increase in myelination. Finally, we show hippocampal volume increase is temporary, returning to baseline after an additional six weeks without aerobic exercise. This is the first demonstration of a change in hippocampal volume in early to middle adulthood suggesting that hippocampal volume is modulated by aerobic exercise throughout the lifespan rather than only in the presence of age related atrophy. It is also the first demonstration of hippocampal volume change over a period of only six weeks, suggesting gross morphometric hippocampal plasticity occurs faster than previously thought.
Original languageEnglish
Pages (from-to)162-170
Number of pages8
JournalNeuroImage
Volume131
Early online date2 Dec 2015
DOIs
Publication statusPublished - 1 May 2016

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Exercise
Hippocampus
Neuroimaging
Atrophy
Blood Vessels
Brain

Keywords

  • Neurogenesis
  • Angiogenesis
  • Dentate gyrus
  • Hippocampus
  • Fitness
  • Exercise
  • Aging
  • Environmental enrichment
  • Myelin
  • Plasticity

Cite this

Thomas, A., Dennis, A., Rawlings, N., Stagg, C., Matthews, L., Morris, M., ... Johansen-Berg, H. (2016). Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise. NeuroImage, 131, 162-170. https://doi.org/10.1016/j.neuroimage.2015.10.090

Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise. / Thomas, Adam; Dennis, Andrea; Rawlings, Nancy; Stagg, Charlotte; Matthews, Lucy; Morris, Martyn; Kolind, Shannon; Foxley, Sean; Jenkinson, Mark; Nichols, Thomas; Dawes, Helen; Bandettini, Peter; Johansen-Berg, Heidi.

In: NeuroImage, Vol. 131, 01.05.2016, p. 162-170.

Research output: Contribution to journalArticle

Thomas, A, Dennis, A, Rawlings, N, Stagg, C, Matthews, L, Morris, M, Kolind, S, Foxley, S, Jenkinson, M, Nichols, T, Dawes, H, Bandettini, P & Johansen-Berg, H 2016, 'Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise.' NeuroImage, vol. 131, pp. 162-170. https://doi.org/10.1016/j.neuroimage.2015.10.090
Thomas, Adam ; Dennis, Andrea ; Rawlings, Nancy ; Stagg, Charlotte ; Matthews, Lucy ; Morris, Martyn ; Kolind, Shannon ; Foxley, Sean ; Jenkinson, Mark ; Nichols, Thomas ; Dawes, Helen ; Bandettini, Peter ; Johansen-Berg, Heidi. / Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise. In: NeuroImage. 2016 ; Vol. 131. pp. 162-170.
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