Molecular pharmacology of V1a vasopressin receptors

John Howl, Mark Wheatley

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

1. 1. Vasopressin, a mammalian neurohypophysial peptide hormone, has diverse physiological actions. 2. 2. Pharmacological studies, using a range of mammalian tissues, have identified three subtypes of vasopressin receptor. 3. 3. The V1a subtype of vasopressin receptor is widely distributed and mediates many central and peripheral actions of vasopressin. 4. 4. The development of subtype-selective vasopressin analogues has provided valuable tools for pharmacological and physical studies of the V1a receptor protein. 5. 5. Pharmacological differences indicate species heterogeneity in the characteristics of V1a receptors and in the expression of hepatic V1a receptors. 6. 6. The cloning of neurohypophysial hormone receptor proteins allows structural and functional comparison of the V1a vasopressin receptors with other G-protein-coupled receptors.

Original languageEnglish
Pages (from-to)1143-1152
Number of pages10
JournalGeneral Pharmacology
Volume26
Issue number6
DOIs
Publication statusPublished - Oct 1995
Externally publishedYes

Keywords

  • antagonist
  • oxytocin
  • peptide hormone
  • receptor
  • Vasopressin

ASJC Scopus subject areas

  • Pharmacology

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