Molecular epidemiology of human rotaviruses in Manipur: genome analysis of rotaviruses of long electropherotype and subgroup I

T Krishnan, B Burke, S Shen, T N Naik, U Desselberger

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

In 1987/88 a winter outbreak of infantile gastroenteritis occurred in Manipur, India which was mainly due to rotaviruses of long electropherotype and subgroup (SG) I. The VP7 gene of one of these viruses (M48) has been cloned and sequenced. It was found to be very closely related to the VP7 genes of the G2 serotype human rotaviruses RV-5 and S2. Follow-up epidemiology of this event in Manipur during 1989-1992 yielded mainly rotaviruses of more conventional characteristics (94 isolates of SG II and long electropherotype, and 90 isolates of SG I and short electropherotype), but also 6 isolates of SG I with long electropherotype, indicating that these viruses continue to circulate in the Manipur community. One isolate of short electropherotype was of subgroup II, and one long electropherotype isolate reacted with the group A but not with either the subgroup I or subgroup II monoclonal antibodies.

Original languageEnglish
Pages (from-to)279-292
Number of pages14
JournalArchives of Virology
Volume134
Issue number3-4
DOIs
Publication statusPublished - Sep 1994

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Molecular Epidemiology
Rotavirus
Genome
Viruses
Gastroenteritis
Genes
Disease Outbreaks
India
Epidemiology
Monoclonal Antibodies

Keywords

  • Amino Acid Sequence
  • Animals
  • Antigens, Viral
  • Base Sequence
  • Capsid/genetics
  • Capsid Proteins
  • Child, Preschool
  • DNA, Viral
  • Disease Outbreaks
  • Gastroenteritis/epidemiology
  • Humans
  • India/epidemiology
  • Infant
  • Molecular Epidemiology
  • Molecular Sequence Data
  • Rotavirus/genetics
  • Rotavirus Infections/epidemiology
  • Seasons
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid

Cite this

Molecular epidemiology of human rotaviruses in Manipur : genome analysis of rotaviruses of long electropherotype and subgroup I. / Krishnan, T; Burke, B; Shen, S; Naik, T N; Desselberger, U.

In: Archives of Virology, Vol. 134, No. 3-4, 09.1994, p. 279-292.

Research output: Contribution to journalArticle

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abstract = "In 1987/88 a winter outbreak of infantile gastroenteritis occurred in Manipur, India which was mainly due to rotaviruses of long electropherotype and subgroup (SG) I. The VP7 gene of one of these viruses (M48) has been cloned and sequenced. It was found to be very closely related to the VP7 genes of the G2 serotype human rotaviruses RV-5 and S2. Follow-up epidemiology of this event in Manipur during 1989-1992 yielded mainly rotaviruses of more conventional characteristics (94 isolates of SG II and long electropherotype, and 90 isolates of SG I and short electropherotype), but also 6 isolates of SG I with long electropherotype, indicating that these viruses continue to circulate in the Manipur community. One isolate of short electropherotype was of subgroup II, and one long electropherotype isolate reacted with the group A but not with either the subgroup I or subgroup II monoclonal antibodies.",
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