Abstract
In 1987/88 a winter outbreak of infantile gastroenteritis occurred in Manipur, India which was mainly due to rotaviruses of long electropherotype and subgroup (SG) I. The VP7 gene of one of these viruses (M48) has been cloned and sequenced. It was found to be very closely related to the VP7 genes of the G2 serotype human rotaviruses RV-5 and S2. Follow-up epidemiology of this event in Manipur during 1989-1992 yielded mainly rotaviruses of more conventional characteristics (94 isolates of SG II and long electropherotype, and 90 isolates of SG I and short electropherotype), but also 6 isolates of SG I with long electropherotype, indicating that these viruses continue to circulate in the Manipur community. One isolate of short electropherotype was of subgroup II, and one long electropherotype isolate reacted with the group A but not with either the subgroup I or subgroup II monoclonal antibodies.
| Original language | English |
|---|---|
| Pages (from-to) | 279-292 |
| Number of pages | 14 |
| Journal | Archives of Virology |
| Volume | 134 |
| Issue number | 3-4 |
| DOIs | |
| Publication status | Published - Sep 1994 |
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Keywords
- Amino Acid Sequence
- Animals
- Antigens, Viral
- Base Sequence
- Capsid/genetics
- Capsid Proteins
- Child, Preschool
- DNA, Viral
- Disease Outbreaks
- Gastroenteritis/epidemiology
- Humans
- India/epidemiology
- Infant
- Molecular Epidemiology
- Molecular Sequence Data
- Rotavirus/genetics
- Rotavirus Infections/epidemiology
- Seasons
- Sequence Homology, Amino Acid
- Sequence Homology, Nucleic Acid
Cite this
Molecular epidemiology of human rotaviruses in Manipur : genome analysis of rotaviruses of long electropherotype and subgroup I. / Krishnan, T; Burke, B; Shen, S; Naik, T N; Desselberger, U.
In: Archives of Virology, Vol. 134, No. 3-4, 09.1994, p. 279-292.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Molecular epidemiology of human rotaviruses in Manipur
T2 - genome analysis of rotaviruses of long electropherotype and subgroup I
AU - Krishnan, T
AU - Burke, B
AU - Shen, S
AU - Naik, T N
AU - Desselberger, U
PY - 1994/9
Y1 - 1994/9
N2 - In 1987/88 a winter outbreak of infantile gastroenteritis occurred in Manipur, India which was mainly due to rotaviruses of long electropherotype and subgroup (SG) I. The VP7 gene of one of these viruses (M48) has been cloned and sequenced. It was found to be very closely related to the VP7 genes of the G2 serotype human rotaviruses RV-5 and S2. Follow-up epidemiology of this event in Manipur during 1989-1992 yielded mainly rotaviruses of more conventional characteristics (94 isolates of SG II and long electropherotype, and 90 isolates of SG I and short electropherotype), but also 6 isolates of SG I with long electropherotype, indicating that these viruses continue to circulate in the Manipur community. One isolate of short electropherotype was of subgroup II, and one long electropherotype isolate reacted with the group A but not with either the subgroup I or subgroup II monoclonal antibodies.
AB - In 1987/88 a winter outbreak of infantile gastroenteritis occurred in Manipur, India which was mainly due to rotaviruses of long electropherotype and subgroup (SG) I. The VP7 gene of one of these viruses (M48) has been cloned and sequenced. It was found to be very closely related to the VP7 genes of the G2 serotype human rotaviruses RV-5 and S2. Follow-up epidemiology of this event in Manipur during 1989-1992 yielded mainly rotaviruses of more conventional characteristics (94 isolates of SG II and long electropherotype, and 90 isolates of SG I and short electropherotype), but also 6 isolates of SG I with long electropherotype, indicating that these viruses continue to circulate in the Manipur community. One isolate of short electropherotype was of subgroup II, and one long electropherotype isolate reacted with the group A but not with either the subgroup I or subgroup II monoclonal antibodies.
KW - Amino Acid Sequence
KW - Animals
KW - Antigens, Viral
KW - Base Sequence
KW - Capsid/genetics
KW - Capsid Proteins
KW - Child, Preschool
KW - DNA, Viral
KW - Disease Outbreaks
KW - Gastroenteritis/epidemiology
KW - Humans
KW - India/epidemiology
KW - Infant
KW - Molecular Epidemiology
KW - Molecular Sequence Data
KW - Rotavirus/genetics
KW - Rotavirus Infections/epidemiology
KW - Seasons
KW - Sequence Homology, Amino Acid
KW - Sequence Homology, Nucleic Acid
U2 - 10.1007/BF01310567
DO - 10.1007/BF01310567
M3 - Article
VL - 134
SP - 279
EP - 292
JO - Archives of Virology
JF - Archives of Virology
SN - 0304-8608
IS - 3-4
ER -