Molecular Effects of Alcohol on Iron Metabolism

Kosha Mehta, Sebastien Farnaud, Vinood B. Patel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter explores the link between iron and alcohol metabolism. Chronic alcohol consumption alters the expression of numerous iron-related proteins, including the liver-secreted systemic iron-regulator hepcidin. Downregulation of hepcidin is the key reason for increased duodenal iron absorption, which causes high circulating and stored iron levels in alcoholics, similar to that attained in hereditary hemochromatosis. The resultant free-iron mediated cytotoxicity is a common determinant of the pathophysiology of cirrhosis, an advanced liver condition observed in both alcoholic liver disease (ALD), and congenital hemochromatosis. Often, alcohol consumption suppresses hematopoiesis and/or hinders normal erythrocyte maturation, which results in anemia. Due to these alcohol-induced changes in iron metabolism, several iron-related biomarkers, like serum levels of ferritin and the glycosylation status of transferrin, are used to detect ALD. Also, modulation of hepcidin expression has been explored as a therapy to limit duodenal iron absorption and thereby restrain the tissue injury mediated by excess iron.

Original languageEnglish
Title of host publicationMolecular Aspects of Alcohol and Nutrition
Subtitle of host publicationA Volume in the Molecular Nutrition Series
EditorsVinood B. Patel
PublisherElsevier
Pages355-368
Number of pages14
ISBN (Electronic)9780128010037
ISBN (Print)9780128007730
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Alcohol
  • Alcoholic liver disease
  • Hemochromatosis
  • Hepcidin
  • Iron

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Mehta, K., Farnaud, S., & Patel, V. B. (2016). Molecular Effects of Alcohol on Iron Metabolism. In V. B. Patel (Ed.), Molecular Aspects of Alcohol and Nutrition: A Volume in the Molecular Nutrition Series (pp. 355-368). Elsevier. https://doi.org/10.1016/B978-0-12-800773-0.00028-8