Abstract
This chapter explores the link between iron and alcohol metabolism. Chronic alcohol consumption alters the expression of numerous iron-related proteins, including the liver-secreted systemic iron-regulator hepcidin. Downregulation of hepcidin is the key reason for increased duodenal iron absorption, which causes high circulating and stored iron levels in alcoholics, similar to that attained in hereditary hemochromatosis. The resultant free-iron mediated cytotoxicity is a common determinant of the pathophysiology of cirrhosis, an advanced liver condition observed in both alcoholic liver disease (ALD), and congenital hemochromatosis. Often, alcohol consumption suppresses hematopoiesis and/or hinders normal erythrocyte maturation, which results in anemia. Due to these alcohol-induced changes in iron metabolism, several iron-related biomarkers, like serum levels of ferritin and the glycosylation status of transferrin, are used to detect ALD. Also, modulation of hepcidin expression has been explored as a therapy to limit duodenal iron absorption and thereby restrain the tissue injury mediated by excess iron.
| Original language | English |
|---|---|
| Title of host publication | Molecular Aspects of Alcohol and Nutrition |
| Subtitle of host publication | A Volume in the Molecular Nutrition Series |
| Editors | Vinood B. Patel |
| Publisher | Elsevier |
| Pages | 355-368 |
| Number of pages | 14 |
| ISBN (Electronic) | 9780128010037 |
| ISBN (Print) | 9780128007730 |
| DOIs | |
| Publication status | Published - 2016 |
| Externally published | Yes |
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Keywords
- Alcohol
- Alcoholic liver disease
- Hemochromatosis
- Hepcidin
- Iron
ASJC Scopus subject areas
- Medicine(all)
Cite this
Molecular Effects of Alcohol on Iron Metabolism. / Mehta, Kosha; Farnaud, Sebastien; Patel, Vinood B.
Molecular Aspects of Alcohol and Nutrition: A Volume in the Molecular Nutrition Series. ed. / Vinood B. Patel. Elsevier, 2016. p. 355-368.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Molecular Effects of Alcohol on Iron Metabolism
AU - Mehta, Kosha
AU - Farnaud, Sebastien
AU - Patel, Vinood B.
PY - 2016
Y1 - 2016
N2 - This chapter explores the link between iron and alcohol metabolism. Chronic alcohol consumption alters the expression of numerous iron-related proteins, including the liver-secreted systemic iron-regulator hepcidin. Downregulation of hepcidin is the key reason for increased duodenal iron absorption, which causes high circulating and stored iron levels in alcoholics, similar to that attained in hereditary hemochromatosis. The resultant free-iron mediated cytotoxicity is a common determinant of the pathophysiology of cirrhosis, an advanced liver condition observed in both alcoholic liver disease (ALD), and congenital hemochromatosis. Often, alcohol consumption suppresses hematopoiesis and/or hinders normal erythrocyte maturation, which results in anemia. Due to these alcohol-induced changes in iron metabolism, several iron-related biomarkers, like serum levels of ferritin and the glycosylation status of transferrin, are used to detect ALD. Also, modulation of hepcidin expression has been explored as a therapy to limit duodenal iron absorption and thereby restrain the tissue injury mediated by excess iron.
AB - This chapter explores the link between iron and alcohol metabolism. Chronic alcohol consumption alters the expression of numerous iron-related proteins, including the liver-secreted systemic iron-regulator hepcidin. Downregulation of hepcidin is the key reason for increased duodenal iron absorption, which causes high circulating and stored iron levels in alcoholics, similar to that attained in hereditary hemochromatosis. The resultant free-iron mediated cytotoxicity is a common determinant of the pathophysiology of cirrhosis, an advanced liver condition observed in both alcoholic liver disease (ALD), and congenital hemochromatosis. Often, alcohol consumption suppresses hematopoiesis and/or hinders normal erythrocyte maturation, which results in anemia. Due to these alcohol-induced changes in iron metabolism, several iron-related biomarkers, like serum levels of ferritin and the glycosylation status of transferrin, are used to detect ALD. Also, modulation of hepcidin expression has been explored as a therapy to limit duodenal iron absorption and thereby restrain the tissue injury mediated by excess iron.
KW - Alcohol
KW - Alcoholic liver disease
KW - Hemochromatosis
KW - Hepcidin
KW - Iron
UR - http://www.scopus.com/inward/record.url?scp=85006276834&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-800773-0.00028-8
DO - 10.1016/B978-0-12-800773-0.00028-8
M3 - Chapter
SN - 9780128007730
SP - 355
EP - 368
BT - Molecular Aspects of Alcohol and Nutrition
A2 - Patel, Vinood B.
PB - Elsevier
ER -